Bcl-2 family proteins and cancer (Q37310180)

19 August 2017

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title

Bcl-2 family proteins and cancer (English)

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19 August 2017

K W Yip

1

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PubMed ID

18955968

19 August 2017

J C Reed

series ordinal

2

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PubMed ID

18955968

19 August 2017

language of work or name

English

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publication date

1 October 2008

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19 August 2017

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19 August 2017

27

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19 August 2017

50

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19 August 2017

6398-6406

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https://scigraph.springernature.com/pub.10.1038/onc.2008.307

19 August 2017

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How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

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Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

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Organelle-specific initiation of cell death pathways

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The pathophysiology of mitochondrial cell death

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Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt.

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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

31 March 2020

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Mitochondrial membrane permeabilization in cell death

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31 March 2020

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Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

31 March 2020

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31 March 2020

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31 March 2020

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Bcl-XL Mutations Suppress Cellular Sensitivity to Antimycin A

31 March 2020

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Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bcl2 and perturbing the cellular redox state

31 March 2020

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Lucifer's labyrinth--ten years of path finding in cell death

31 March 2020

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A novel form of Epstein-Barr virus latency in normal B cells in vivo

31 March 2020

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In vitro evaluation of the anticancer effect of lactoferrin and tea polyphenol combination on oral carcinoma cells

31 March 2020

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mir-29 regulates Mcl-1 protein expression and apoptosis

31 March 2020

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

31 March 2020

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Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

31 March 2020

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Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia

31 March 2020

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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

31 March 2020

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.307

Regulation of cell death: the calcium-apoptosis link

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.307

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.307

The triterpenoid CDDO induces apoptosis in refractory CLL B cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Inhibition of anti-apoptotic Bcl-2 family proteins by natural polyphenols: new avenues for cancer chemoprevention and chemotherapy

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.307

Mitochondria, AIF and caspases--rivaling for cell death execution.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

ER stress triggers apoptosis by activating BH3-only protein Bim

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Apoptosis-based therapies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Proapoptotic multidomain Bcl-2/Bax-family proteins: mechanisms, physiological roles, and therapeutic opportunities

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.307

Bcl-2-family proteins and hematologic malignancies: history and future prospects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Apoptosis-based therapies for hematologic malignancies

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Signal integration in the endoplasmic reticulum unfolded protein response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

BID regulation by p53 contributes to chemosensitivity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Bcl-2 family proteins as ion-channels

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

2-Methoxy antimycin reveals a unique mechanism for Bcl-x(L) inhibition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

The DAP-kinase family of proteins: study of a novel group of calcium-regulated death-promoting kinases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

The Bcl-2 protein: a prognostic indicator strongly related to p53 protein in lymph node-negative breast cancer patients.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

The role of BH3-only proteins in the immune system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Clinical significance of bcl-2-MBR gene rearrangement and protein expression in diffuse large-cell non-Hodgkin's lymphoma: an analysis of 83 cases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Bcl-2 on the endoplasmic reticulum: protecting the mitochondria from a distance

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Involvement of the bcl-2 gene in human follicular lymphoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Caspase-dependent activation of calpain during drug-induced apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Bax cleavage is mediated by calpain during drug-induced apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Endoplasmic reticulum stress: cell life and death decisions.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

BI-1 regulates endoplasmic reticulum Ca2+ homeostasis downstream of Bcl-2 family proteins

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.307

Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.307

A TR3/Nur77 peptide-based high-throughput fluorescence polarization screen for small molecule Bcl-B inhibitors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Prognostic significance of the Epstein-Barr virus, p53, Bcl-2, and survivin in nasopharyngeal cancer

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.307

Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.307

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.307

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

31 March 2020

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https://api.crossref.org/works/10.1038%2FONC.2008.307

bcl-2 and other genomic alterations in the prognosis of large-cell lymphoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.307

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Identifiers

DOI

10.1038/ONC.2008.307

1 reference

19 August 2017

1 reference

PubMed ID

18955968