Twenty years of p53 research: structural and functional aspects of the p53 protein (Q33807787)

29 July 2017

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title

Twenty years of p53 research: structural and functional aspects of the p53 protein (English)

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29 July 2017

May P

1

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29 July 2017

May E

series ordinal

2

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29 July 2017

language of work or name

English

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publication date

1 December 1999

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29 July 2017

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29 July 2017

18

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29 July 2017

7621-7636

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29 July 2017

53

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1203285

29 July 2017

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cites work

p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Regulation of the human hsp70 promoter by p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Involvement of p53 in cell differentiation and development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Reciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: implications for regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Prevalence of serum antibodies against the p53 tumor suppressor gene protein in various cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Recruitment of p300/CBP in p53-dependent signal pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Suppression of human colorectal carcinoma cell growth by wild-type p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Oncogenes and the strategy of growth factors

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

p14ARF links the tumour suppressors RB and p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Therapeutic targeting of the p53 tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

UV but not gamma-irradiation induces specific transcriptional activity of p53 in primary hepatocytes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Transformation associated p53 protein is encoded by a gene on human chromosome 17.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Molecular epidemiology of human cancer risk: gene-environment interactions and p53 mutation spectrum in human lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

1 reference

7 January 2021

Further characterisation of the p53 responsive element--identification of new candidate genes for trans-activation by p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Mouse p53 inhibits SV40 origin-dependent DNA replication.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Radiation-induced cell cycle arrest compromised by p21 deficiency

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Interaction of p53 with the human Rad51 protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Induction of the growth inhibitor IGF-binding protein 3 by p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Role of p53 in apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Presence of circulating antibodies against cellular protein p53 in a notable proportion of children with B-cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

TP53 tumor suppressor gene: a model for investigating human mutagenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Identification and partial characterization of new antigens from simian virus 40-transformed mouse cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Genetic mechanisms of tumor suppression by the human p53 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Stabilization and activation of p53 are regulated independently by different phosphorylation events

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The p53 activation and apoptosis induced by DNA damage are reversibly inhibited by salicylate

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The INK4a/ARF tumor suppressor: one gene--two products--two pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Multistage Friend erythroleukemia: independent origin of tumor clones with normal or rearranged p53 cellular oncogenes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Thymocyte apoptosis induced by p53-dependent and independent pathways.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

High-resolution structure of the oligomerization domain of p53 by multidimensional NMR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Interhelical angles in the solution structure of the oligomerization domain of p53: correction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Evidence for allosteric variants of wild-type p53, a tumour suppressor protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

A p53-dependent mouse spindle checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

p53 functions as a cell cycle control protein in osteosarcomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Gain of function mutations in p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Inhibition of DNA replication factor RPA by p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Definition of a consensus binding site for p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Wild-type p53 can inhibit oncogene-mediated focus formation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Presence of a potent transcription activating sequence in the p53 protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The p53 proto-oncogene can act as a suppressor of transformation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

A transcriptionally active DNA-binding site for human p53 protein complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

p53 and DNA polymerase alpha compete for binding to SV40 T antigen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The complexity of p53 modulation: emerging patterns from divergent signals

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Wild-type p53 can down-modulate the activity of various promoters

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Preferential DNA repair in expressed genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Clinical implications of the p53 tumor-suppressor gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Induction of apoptosis in HeLa cells by trans-activation-deficient p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The transactivator proteins VP16 and GAL4 bind replication factor A.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Immunological evidence for the association of p53 with a heat shock protein, hsc70, in p53-plus-ras-transformed cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Allosteric activation of latent p53 tetramers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Two distinct signaling pathways activate the latent DNA binding function of p53 in a casein kinase II-independent manner.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Regulation of the specific DNA binding function of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Activation of the cryptic DNA binding function of mutant forms of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Small peptides activate the latent sequence-specific DNA binding function of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Localization of gene for human p53 tumour antigen to band 17p13.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

A novel p53-inducible gene, PAG608, encodes a nuclear zinc finger protein whose overexpression promotes apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Two cellular proteins that bind to wild-type but not mutant p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Tumor spectrum analysis in p53-mutant mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Identification of redox/repair protein Ref-1 as a potent activator of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The cellular oncogene p53 can be activated by mutagenesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Co-operation between the p53 protein tumor antigen and platelet-poor plasma in the induction of cellular DNA synthesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The emerging p53 gene family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Identification of p53 as a sequence-specific DNA-binding protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

p53: puzzle and paradigm

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Oligomerization of oncoprotein p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Regulation of Mdm2-directed degradation by the C terminus of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

T antigen is bound to a host protein in SY40-transformed cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Binding and modulation of p53 by p300/CBP coactivators

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Cytokines inhibit p53-mediated apoptosis but not p53-mediated G1 arrest

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

p53 status and the efficacy of cancer therapy in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Human TAFII31 protein is a transcriptional coactivator of the p53 protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The WT1 gene product stabilizes p53 and inhibits p53-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Tumor suppressor genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Identification of new polypeptide species (48–55K) immunoprecipitable by antiserum to purified large T antigen and present in SV40-infected and -transformed cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Microinjection of monoclonal antibody to protein p53 inhibits serum-induced DNA synthesis in 3T3 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Human p53 gene localized to short arm of chromosome 17

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Different forms of p53 detected by monoclonal antibodies in non-dividing and dividing lymphocytes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Tumor suppressor p53: analysis of wild-type and mutant p53 complexes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

SV40-53K antigen: A possible role for 53K in normal cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Cytoplasmic sequestration of wild-type p53 protein impairs the G1 checkpoint after DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

An embryo protein induced by SV40 virus transformation of mouse cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Wild-type p53 negatively regulates the expression of a microtubule-associated protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Activation of the human homologue of the Drosophila sina gene in apoptosis and tumor suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Mutations in the p53 gene occur in diverse human tumour types

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

p53-catalyzed annealing of complementary single-stranded nucleic acids

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Induced N- and C-terminal cleavage of p53: a core fragment of p53, generated by interaction with damaged DNA, promotes cleavage of the N-terminus of full-length p53, whereas ssDNA induces C-terminal cleavage of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Amplification of a gene encoding a p53-associated protein in human sarcomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The p53 cellular tumor antigen: gene structure, expression and protein properties

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Regulation of the Cellular p53 Tumor Antigen in Teratocarcinoma Cells and Their Differentiated Progeny

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The DNA-binding domain of p53 contains the four conserved regions and the major mutation hot spots

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Sequence-specific transcriptional activation is essential for growth suppression by p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Specific interaction between the p53 cellular tumour antigen and major heat shock proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

A model for p53-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Role of cysteine residues in regulation of p53 function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Growth regulation of a cellular tumour antigen, p53, in nontransformed cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Two Distinct Mechanisms Regulate the Levels of a Cellular Tumor Antigen, p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Abelson murine leukemia virus-induced tumors elicit antibodies against a host cell protein, P50

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Deletion of 5'-coding sequences of the cellular p53 gene in mouse erythroleukemia: a novel mechanism of oncogene regulation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Analysis of a protein-binding domain of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Essential role for p53-mediated transcription in E1A-induced apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

DNA damage activates p53 through a phosphorylation-acetylation cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The polyproline region of p53 is required to activate apoptosis but not growth arrest.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

A novel protein with strong homology to the tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Reactivation of mutant p53 through interaction of a C-terminal peptide with the core domain.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Wild-type p53 binds to the TATA-binding protein and represses transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Tumor surveillance via the ARF-p53 pathway.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

DNA damage induces phosphorylation of the amino terminus of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Structural aspects of the p53 protein in relation to gene evolution: a second look.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Potential role of human cytomegalovirus and p53 interaction in coronary restenosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

How phosphorylation regulates the activity of p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Mutant conformation of p53. Precise epitope mapping using a filamentous phage epitope library

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Role of a p53 polymorphism in the development of human papillomavirus-associated cancer.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Bcl-2 expression promotes B- but not T-lymphoid development in scid mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

EBNA-5, an Epstein-Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Genetic analysis of cellular senescence.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Murine double minute (MDM2) blocks p53-coactivator interaction, a new mechanism for inhibition of p53-dependent gene expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Identification of a novel p53 functional domain that is necessary for efficient growth suppression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

p53 modulation of TFIIH-associated nucleotide excision repair activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

p53 domains: identification and characterization of two autonomous DNA-binding regions.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Life, death, and the pursuit of apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

The p53-mdm-2 autoregulatory feedback loop

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Monoclonal antibody analysis of p53 expression in normal and transformed cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

p53-mediated cell death: relationship to cell cycle control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Sunburn and p53 in the onset of skin cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203285

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203285

1 reference

Dimensions Publication ID

29 July 2017

0 references

1 reference