Alternative pathways for the extension of cellular life span: inactivation of p53/pRb and expression of telomerase (Q33807819)

29 July 2017

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title

Alternative pathways for the extension of cellular life span: inactivation of p53/pRb and expression of telomerase (English)

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29 July 2017

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Vaziri H

1

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29 July 2017

Benchimol S

series ordinal

2

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29 July 2017

language of work or name

English

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publication date

1 December 1999

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29 July 2017

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29 July 2017

volume

18

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29 July 2017

issue

53

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29 July 2017

page(s)

7676-7680

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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

29 July 2017

cites work

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Increased activity of p53 in senescing fibroblasts

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Telomere length predicts replicative capacity of human fibroblasts

21 January 2018

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Genetic instability as a consequence of inappropriate entry into and progression through S-phase.

21 January 2018

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Reconstitution of human telomerase activity in vitro

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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

21 January 2018

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Extension of life-span by introduction of telomerase into normal human cells

21 January 2018

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Bypass of Senescence After Disruption of p21 CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

21 January 2018

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Radiation-induced cell cycle arrest compromised by p21 deficiency

21 January 2018

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Telomere length and replicative aging in human vascular tissues

21 January 2018

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Telomere maintenance mechanisms and cellular immortalization.

21 January 2018

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Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

21 January 2018

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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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The RNA component of human telomerase

21 January 2018

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Inactivation of p16 in human mammary epithelial cells by CpG island methylation

21 January 2018

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Identification of a specific telomere terminal transferase activity in Tetrahymena extracts

21 January 2018

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Telomerase activity is sufficient to allow transformed cells to escape from crisis

21 January 2018

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Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

21 January 2018

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Telomeres shorten during ageing of human fibroblasts

21 January 2018

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The telomere hypothesis of cellular aging

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

pRB plays an essential role in cell cycle arrest induced by DNA damage

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

A mammalian telomerase-associated protein

21 January 2018

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Human telomerase contains evolutionarily conserved catalytic and structural subunits

21 January 2018

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The serial cultivation of human diploid cell strains

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

Isolation of a candidate human telomerase catalytic subunit gene, which reveals complex splicing patterns in different cell types.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

Increased p53 Protein Associated with Aging in Human Diploid Fibroblasts

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

Telomerase activation by the E6 gene product of human papillomavirus type 16.

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

Essential role of mouse telomerase in highly proliferative organs

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

p53, the cellular gatekeeper for growth and division

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

Reverse transcriptase motifs in the catalytic subunit of telomerase

21 January 2018

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hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

Absence of cancer-associated changes in human fibroblasts immortalized with telomerase

21 January 2018

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The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats

21 January 2018

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Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

21 January 2018

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Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen

21 January 2018

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The telomerase reverse transcriptase: components and regulation

21 January 2018

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A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

21 January 2018

1 reference

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Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts

21 January 2018

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Role of the INK4a locus in tumor suppression and cell mortality.

21 January 2018

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Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen

21 January 2018

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ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

Analysis of genomic integrity and p53-dependent G1 checkpoint in telomerase-induced extended-life-span human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

21 January 2018

Myc activates telomerase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

Origin of Concatemeric T7DNA

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

The retinoblastoma protein and cell cycle control

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

7 January 2021

Telomere elongation in immortal human cells without detectable telomerase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

7 January 2021

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

7 January 2021

A role for both RB and p53 in the regulation of human cellular senescence

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

7 January 2021

Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

7 January 2021

EARLY CHROMOSOMAL CHANGES IN SV40-INFECTED HUMAN FIBROBLAST CULTURES

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203016

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203016

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Dimensions Publication ID

29 July 2017

1041550851

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1 reference