Abnormal kinetochore-generated pulling forces from expressing a N-terminally modified Hec1. (Q33813043)

29 July 2017

Abnormal kinetochore-generated pulling forces from expressing a N-terminally modified Hec1. (English)

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29 July 2017

6

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29 July 2017

Pierangela Totta

3

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author name string

Marta Mattiuzzo

1

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29 July 2017

Giulia Vargiu

2

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29 July 2017

Mario Fiore

4

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29 July 2017

Claudio Ciferri

5

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29 July 2017

Francesca Degrassi

7

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29 July 2017

language of work or name

English

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publication date

28 January 2011

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29 July 2017

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29 July 2017

6

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29 July 2017

1

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29 July 2017

e16307

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Creative Commons Attribution 4.0 International

29 July 2017

start time

28 January 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3030568/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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The Ndc80 kinetochore complex forms oligomeric arrays along microtubules

4 July 2018

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Mechanisms of force generation by end-on kinetochore-microtubule attachments.

4 July 2018

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Force and length in the mitotic spindle

4 July 2018

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siRNA-mediated knockdown against CDCA1 and KNTC2, both frequently overexpressed in colorectal and gastric cancers, suppresses cell proliferation and induces apoptosis

4 July 2018

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Hec1 contributes to mitotic centrosomal microtubule growth for proper spindle assembly through interaction with Hice1.

4 July 2018

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Aneuploidy in mitosis of PtK1 cells is generated by random loss and nondisjunction of individual chromosomes.

4 July 2018

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The life and miracles of kinetochores

4 July 2018

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Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E.

4 July 2018

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Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

4 July 2018

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Kinetochore-microtubule attachment relies on the disordered N-terminal tail domain of Hec1.

4 July 2018

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Kinetochore attachments require an interaction between unstructured tails on microtubules and Ndc80(Hec1).

4 July 2018

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Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly.

4 July 2018

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Hec1 overexpression hyperactivates the mitotic checkpoint and induces tumor formation in vivo

4 July 2018

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Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex

4 July 2018

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CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether

4 July 2018

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Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain

4 July 2018

1 reference

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Kinetochore-microtubule interactions: the means to the end

4 July 2018

1 reference

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Molecular architecture of the kinetochore-microtubule interface

4 July 2018

1 reference

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Concerning the origin of malignant tumours by Theodor Boveri. Translated and annotated by Henry Harris

4 July 2018

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Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment

4 July 2018

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The spindle-assembly checkpoint in space and time

4 July 2018

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A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy

4 July 2018

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The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

The conserved KMN network constitutes the core microtubule-binding site of the kinetochore

4 July 2018

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Kinetochore microtubule dynamics and attachment stability are regulated by Hec1

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Activation of CDCA1-KNTC2, members of centromere protein complex, involved in pulmonary carcinogenesis

4 July 2018

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Does aneuploidy cause cancer?

4 July 2018

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Aurora B is enriched at merotelic attachment sites, where it regulates MCAK.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

HURP is part of a Ran-dependent complex involved in spindle formation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

The kinetochore and cancer: what's the connection?

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

On the road to cancer: aneuploidy and the mitotic checkpoint

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Aneuploidy: a matter of bad connections.

4 July 2018

1 reference

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Architecture of the human ndc80-hec1 complex, a critical constituent of the outer kinetochore

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Microarray analysis identifies a death-from-cancer signature predicting therapy failure in patients with multiple types of cancer

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Centromere protein H is up-regulated in primary human colorectal cancer and its overexpression induces aneuploidy

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Molecular organization of the Ndc80 complex, an essential kinetochore component

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Microtubule-depolymerizing kinesins

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Truncating APC mutations have dominant effects on proliferation, spindle checkpoint control, survival and chromosome stability.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Timing and checkpoints in the regulation of mitotic progression

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

The vertebrate Ndc80 complex contains Spc24 and Spc25 homologs, which are required to establish and maintain kinetochore-microtubule attachment

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Identification of two novel components of the human NDC80 kinetochore complex

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Nuf2 and Hec1 are required for retention of the checkpoint proteins Mad1 and Mad2 to kinetochores

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

The Kin I kinesins are microtubule end-stimulated ATPases

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Role of Hec1 in spindle checkpoint signaling and kinetochore recruitment of Mad1/Mad2

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Gene expression profiling predicts clinical outcome of breast cancer

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Identification of essential genes in cultured mammalian cells using small interfering RNAs.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

The molecular structure of green fluorescent protein

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

CENP-E function at kinetochores is essential for chromosome alignment.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

HEC, a novel nuclear protein rich in leucine heptad repeats specifically involved in mitosis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Genetic instability in colorectal cancers

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

Sites of microtubule assembly and disassembly in the mitotic spindle

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3030568

4 July 2018

Aneuploidy and cancer

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016307

Emerging functions of force-producing kinetochore motors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016307

Mechanisms of spindle-pole organization are influenced by kinetochore activity in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016307

Dynamic behavior of Nuf2-Hec1 complex that localizes to the centrosome and centromere and is essential for mitotic progression in vertebrate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016307

HURP Is a Ran-Importin β-Regulated Protein that Stabilizes Kinetochore Microtubules in the Vicinity of Chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0016307

10.1371/JOURNAL.PONE.0016307

21 January 2018

Identifiers

DOI

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29 July 2017

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29 July 2017

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