CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice (Q33816616)

29 July 2017

title

CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice (English)

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29 July 2017

Timothy Sullivan

1

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29 July 2017

Zhenhua Miao

2

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29 July 2017

Daniel J Dairaghi

3

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29 July 2017

Antoni Krasinski

4

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29 July 2017

Yu Wang

5

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29 July 2017

Bin N Zhao

6

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29 July 2017

Trageen Baumgart

7

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29 July 2017

Linda S Ertl

8

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29 July 2017

Andrew Pennell

9

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29 July 2017

Lisa Seitz

10

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29 July 2017

Jay Powers

11

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29 July 2017

Ruiping Zhao

12

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29 July 2017

Solomon Ungashe

13

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29 July 2017

Zheng Wei

14

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29 July 2017

Landin Boring

15

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29 July 2017

Chia-Lin Tsou

16

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29 July 2017

Israel Charo

17

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29 July 2017

Robert D Berahovich

18

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29 July 2017

Thomas J Schall

19

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29 July 2017

Juan C Jaen

20

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29 July 2017

publication date

28 August 2013

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American Journal of Physiology - Renal Physiology

29 July 2017

published in

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29 July 2017

volume

305

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29 July 2017

issue

9

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29 July 2017

page(s)

F1288-97

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Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease

29 July 2017

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4 July 2018

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4 July 2018

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CCR2 modulates inflammatory and metabolic effects of high-fat feeding

4 July 2018

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4 July 2018

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Obesity is associated with macrophage accumulation in adipose tissue

4 July 2018

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4 July 2018

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4 July 2018

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Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice

4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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4 July 2018

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Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury

21 January 2018

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Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db/db mice.

21 January 2018

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Monocyte chemoattractant protein-1 promotes the development of diabetic renal injury in streptozotocin-treated mice

21 January 2018

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Pharmacokinetic and pharmacodynamic evaluation of the novel CCR1 antagonist CCX354 in healthy human subjects: implications for selection of clinical dose.

21 January 2018

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CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice

21 January 2018

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21 January 2018

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Association of monocyte chemoattractant protein-1 with renal tubular damage in diabetic nephropathy

21 January 2018

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Pharmacological inhibition of C-C chemokine receptor 2 decreases macrophage infiltration in the aortic root of the human C-C chemokine receptor 2/apolipoprotein E-/- mouse: magnetic resonance imaging assessment

21 January 2018

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An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes.

21 January 2018

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21 January 2018

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Blockade of CCL2/CCR2 signalling ameliorates diabetic nephropathy in db/db mice

21 January 2018

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Urinary monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth factor (CCN2) as prognostic markers for progression of diabetic nephropathy.

21 January 2018

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C-C chemokine receptor 2 inhibitor improves diet-induced development of insulin resistance and hepatic steatosis in mice

21 January 2018

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Inhibition of CCR2 ameliorates insulin resistance and hepatic steatosis in db/db mice.

21 January 2018

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Inhibition of the chemokine (C-C motif) ligand 2/chemokine (C-C motif) receptor 2 pathway attenuates hyperglycaemia and inflammation in a mouse model of hepatic steatosis and lipoatrophy

21 January 2018

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Renin-angiotensin system activation and interstitial inflammation in human diabetic nephropathy.

21 January 2018

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A novel C-C chemokine receptor 2 antagonist prevents progression of albuminuria and atherosclerosis in mouse models

30 October 2018

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12 December 2020

Early glomerular macrophage recruitment in streptozotocin-induced diabetic rats

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12 December 2020

Macrophage accumulation in human progressive diabetic nephropathy

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12 December 2020

Chemokine receptor antagonists

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12 December 2020

Inhibition of MCP-1/CCR2 pathway ameliorates the development of diabetic nephropathy

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12 December 2020

The role of macrophages in diabetic glomerulosclerosis

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12 December 2020

CCR2 receptor blockade alters blood monocyte subpopulations but does not affect atherosclerotic lesions in apoE(-/-) mice

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12 December 2020

Targeting the MCP-1/CCR2 System in diabetic kidney disease

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12 December 2020

Mouse models of diabetic nephropathy

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12 December 2020

10.1152/AJPRENAL.00316.2013

Identifiers

DOI

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29 July 2017

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29 July 2017

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