Human herpesvirus 8 interleukin-6 (vIL-6) signals through gp130 but has structural and receptor-binding properties distinct from those of human IL-6. (Q33819690)

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English	Human herpesvirus 8 interleukin-6 (vIL-6) signals through gp130 but has structural and receptor-binding properties distinct from those of human IL-6.	scientific article

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12 December 2019

Human herpesvirus 8 interleukin-6 (vIL-6) signals through gp130 but has structural and receptor-binding properties distinct from those of human IL-6 (English)

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12 December 2019

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Kaposi's sarcoma-associated herpesvirus

object named as

Human herpesvirus 8

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X Wan

1

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12 December 2019

H Wang

2

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12 December 2019

J Nicholas

3

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1 October 1999

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12 December 2019

Journal of Virology

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73

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12 December 2019

8268-8278

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12 December 2019

10

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12 December 2019

Mechanisms of growth control of Kaposi's sarcoma-associated herpes virus-associated primary effusion lymphoma cells.

1 reference

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4 July 2018

Crystal structure of a cytokine-binding region of gp130.

1 reference

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4 July 2018

Human herpesvirus type 8 interleukin-6 homologue is functionally active on human myeloma cells.

1 reference

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4 July 2018

A Kaposi's sarcoma-associated herpesvirus-encoded cytokine homolog (vIL-6) activates signaling through the shared gp130 receptor subunit

1 reference

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4 July 2018

Cell-homologous genes in the Kaposi's sarcoma-associated rhadinovirus human herpesvirus 8: determinants of its pathogenicity?

1 reference

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4 July 2018

Interleukin-6: structure-function relationships.

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4 July 2018

Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6.

1 reference

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4 July 2018

A single 13-kilobase divergent locus in the Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genome contains nine open reading frames that are homologous to or related to cellular proteins

1 reference

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4 July 2018

Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8)

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4 July 2018

Molecular mimicry of human cytokine and cytokine response pathway genes by KSHV.

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4 July 2018

The lipopolysaccharide-binding protein is a secretory class 1 acute-phase protein whose gene is transcriptionally activated by APRF/STAT/3 and other cytokine-inducible nuclear proteins

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4 July 2018

DNA binding specificity of the CCAAT/enhancer-binding protein transcription factor family

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Evidence for posttranscriptional regulation of C/EBPalpha and C/EBPbeta isoform expression during the lipopolysaccharide-mediated acute-phase response

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4 July 2018

The interleukin-6 (IL-6) partial antagonist (Q159E,T162P)IL-6 interacts with the IL-6 receptor and gp130 but fails to induce a stable hexameric receptor complex

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4 July 2018

The role of Stat and C/EBP transcription factors in the synergistic activation of rat serine protease inhibitor-3 gene by interleukin-6 and dexamethasone

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4 July 2018

Saturation mutagenesis of the human interleukin 6 receptor-binding site: implications for its three-dimensional structure

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4 July 2018

Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130

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4 July 2018

The human beta fibrinogen promoter contains a hepatocyte nuclear factor 1-dependent interleukin-6-responsive element

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4 July 2018

Development of a human interleukin-6 receptor antagonist.

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4 July 2018

Roles of disulfide bonds in recombinant human interleukin 6 conformation

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4 July 2018

Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma

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4 July 2018

Development of an interleukin (IL) 6 receptor antagonist that inhibits IL-6-dependent growth of human myeloma cells.

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4 July 2018

Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma

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4 July 2018

Rational design of a receptor super-antagonist of human interleukin-6.

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4 July 2018

Interleukin-6 (IL-6) antagonism by soluble IL-6 receptor alpha mutated in the predicted gp130-binding interface

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4 July 2018

Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling

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4 July 2018

Kaposi's sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas

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4 July 2018

Structure-function analysis of the C-terminal segment of human interleukin-6.

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4 July 2018

Kaposi's sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman's disease

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4 July 2018

Signaling through the hematopoietic cytokine receptors.

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4 July 2018

A role for a new herpes virus (KSHV) in different forms of Kaposi's sarcoma

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4 July 2018

Functional distinction of two regions of human interleukin 6 important for signal transduction via gp130.

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4 July 2018

Cooperative transcriptional activity of Jun and Stat3 beta, a short form of Stat3

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4 July 2018

Structure-function analysis of human IL-6: identification of two distinct regions that are important for receptor binding

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4 July 2018

Identification of two novel regions of human IL-6 responsible for receptor binding and signal transduction.

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4 July 2018

Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

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4 July 2018

Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation

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4 July 2018

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

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4 July 2018

Rapid and efficient site-specific mutagenesis without phenotypic selection

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4 July 2018

Interleukin 6 induces a liver-specific nuclear protein that binds to the promoter of acute-phase genes.

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4 July 2018

Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor

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4 July 2018

IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP

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4 July 2018

A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family

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4 July 2018

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4 July 2018

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4 July 2018

AIDS Kaposi sarcoma-derived cells produce and respond to interleukin 6

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4 July 2018

Transformation of primary human endothelial cells by Kaposi's sarcoma-associated herpesvirus.

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29 October 2018

Kaposi's sarcoma-associated herpesvirus infection and multiple myeloma

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29 October 2018

Use of immobilized synthetic peptides for the identification of contact sites between human interleukin-6 and its receptor.

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29 October 2018

Kaposi's sarcoma-associated herpesvirus infection of bone marrow dendritic cells from multiple myeloma patients

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12 December 2020

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Theoretical investigation of IL-6 multiprotein receptor assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/10482577

12 December 2020

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Immunodeficiency and IL-6 production by peripheral blood monocytes in multicentric Castleman's disease

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human herpesvirus-like nucleic acid in various forms of Kaposi's sarcoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10482577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Herpesvirus-like DNA sequences in patients with Mediterranean Kaposi's sarcoma

1 reference

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12 December 2020

based on heuristic

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Tumor necrosis factor alpha promotes nuclear localization of cytokine-inducible CCAAT/enhancer binding protein isoforms in hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/10482577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/10482577

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of rat acute-phase proteins by interleukin 6 in vivo

1 reference

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12 December 2020

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Interleukin-6 is a potent myeloma-cell growth factor in patients with aggressive multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/10482577

12 December 2020

based on heuristic

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Involvement of the Arg179 in the active site of human IL-6

1 reference

https://pubmed.ncbi.nlm.nih.gov/10482577

12 December 2020

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12 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10482577%20AND%20SRC:MED&resulttype=core&format=json

12 December 2019

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