Computational backbone mutagenesis of Abeta peptides: probing the role of backbone hydrogen bonds in aggregation (Q33821231)

29 July 2017

Computational backbone mutagenesis of Abeta peptides: probing the role of backbone hydrogen bonds in aggregation (English)

1 reference

29 July 2017

Takako Takeda

1

1 reference

PubMed ID

20302321

29 July 2017

Dmitri K Klimov

series ordinal

2

1 reference

PubMed ID

20302321

29 July 2017

language of work or name

English

0 references

publication date

1 April 2010

1 reference

29 July 2017

8

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Journal of Physical Chemistry B

inferred from page(s)

published in

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29 July 2017

114

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29 July 2017

14

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29 July 2017

4755-4762

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Side chain interactions can impede amyloid fibril growth: replica exchange simulations of Abeta peptide mutant

29 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862262

Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862262

Probing energetics of Abeta fibril elongation by molecular dynamics simulations

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862262

Probing the effect of amino-terminal truncation for Abeta1-40 peptides

4 July 2018

1 reference

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Interpeptide interactions induce helix to strand structural transition in Abeta peptides

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862262

Replica exchange simulations of the thermodynamics of Abeta fibril growth

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862262

Molecular structural basis for polymorphism in Alzheimer's -amyloid fibrils

4 July 2018

1 reference

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Role of water in mediating the assembly of Alzheimer amyloid-beta Abeta16-22 protofilaments

4 July 2018

1 reference

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Temperature-induced dissociation of Abeta monomers from amyloid fibril

4 July 2018

1 reference

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Alzheimer's Abeta peptides containing an isostructural backbone mutation afford distinct aggregate morphologies but analogous cytotoxicity. Evidence for a common low-abundance toxic structure(s)?

4 July 2018

1 reference

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Modeling the Alzheimer Abeta17-42 fibril architecture: tight intermolecular sheet-sheet association and intramolecular hydrated cavities

4 July 2018

1 reference

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New insights into the mechanism of Alzheimer amyloid-beta fibrillogenesis inhibition by N-methylated peptides

4 July 2018

1 reference

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Structure and dynamics of parallel beta-sheets, hydrophobic core, and loops in Alzheimer's A beta fibrils

4 July 2018

1 reference

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

4 July 2018

1 reference

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Monomer adds to preformed structured oligomers of Abeta-peptides by a two-stage dock-lock mechanism.

4 July 2018

1 reference

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Amide-to-E-olefin versus amide-to-ester backbone H-bond perturbations: Evaluating the O-O repulsion for extracting H-bond energies

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862262

Simulations as analytical tools to understand protein aggregation and predict amyloid conformation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862262

Spatial separation of beta-sheet domains of beta-amyloid: disruption of each beta-sheet by N-methyl amino acids

4 July 2018

1 reference

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Polymorphic fibril formation by residues 10-40 of the Alzheimer's beta-amyloid peptide

4 July 2018

1 reference

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Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils

4 July 2018

1 reference

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Probing the pressure-temperature stability of amyloid fibrils provides new insights into their molecular properties

4 July 2018

1 reference

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3D structure of Alzheimer's amyloid-beta(1-42) fibrils

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862262

Molecular dynamics simulations of Alzheimer's beta-amyloid protofilaments

4 July 2018

1 reference

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Structure of the cross-beta spine of amyloid-like fibrils

4 July 2018

1 reference

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Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

4 July 2018

1 reference

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Analysis of protein folding and function using backbone modified proteins

4 July 2018

1 reference

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UCSF Chimera--a visualization system for exploratory research and analysis

4 July 2018

1 reference

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Folding proteins in fatal ways

4 July 2018

1 reference

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Protein folding and misfolding

4 July 2018

1 reference

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Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies

4 July 2018

1 reference

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Peptide aggregation in neurodegenerative disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862262

Evaluation of a fast implicit solvent model for molecular dynamics simulations

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862262

Abeta amyloid fibrils possess a core structure highly resistant to hydrogen exchange

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862262

Folding simulations of a three-stranded antiparallel beta -sheet peptide

4 July 2018

1 reference

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Alzheimer's amyloid fibrils: structure and assembly

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862262

Alzheimer's disease amyloid propagation by a template-dependent dock-lock mechanism

4 July 2018

1 reference

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Native proteins are surface-molten solids: application of the Lindemann criterion for the solid versus liquid state

4 July 2018

1 reference

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Dictionary of protein secondary structure: pattern recognition of hydrogen-bonded and geometrical features

4 July 2018

1 reference

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Targeting the early steps of Abeta16-22 protofibril disassembly by N-methylated inhibitors: a numerical study.

4 July 2018

1 reference

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E-olefin dipeptide isostere incorporation into a polypeptide backbone enables hydrogen bond perturbation: probing the requirements for Alzheimer's amyloidogenesis.

29 October 2018

1 reference

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Elongation of ordered peptide aggregate of an amyloidogenic hexapeptide NFGAIL observed in molecular dynamics simulations with explicit solvent

29 October 2018

1 reference

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Thermodynamics of A beta(1-40) amyloid fibril elongation

29 October 2018

1 reference

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Characterization of chemical exchange between soluble and aggregated states of beta-amyloid by solution-state NMR upon variation of salt conditions.

29 October 2018

1 reference

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Alzheimer's disease Abeta peptide fragment 10-30 forms a spectrum of metastable oligomers with marked preference for N to N and C to C monomer termini proximity

29 October 2018

1 reference

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Kinetic analysis of beta-amyloid fibril elongation

29 October 2018

1 reference

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Solution NMR studies of the A beta(1-40) and A beta(1-42) peptides establish that the Met35 oxidation state affects the mechanism of amyloid formation

29 October 2018

1 reference

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Elucidation of primary structure elements controlling early amyloid beta-protein oligomerization.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862262

Probing the role of backbone hydrogen bonding in beta-amyloid fibrils with inhibitor peptides containing ester bonds at alternate positions.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862262

Deposition of monomeric, not oligomeric, Abeta mediates growth of Alzheimer's disease amyloid plaques in human brain preparations.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862262

Surface structure of amyloid-beta fibrils contributes to cytotoxicity

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20302321

12 December 2020

inferred from PubMed ID database lookup

Replica exchange molecular dynamics simulations of amyloid peptide aggregation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20302321

12 December 2020

inferred from PubMed ID database lookup

Optimized Monte Carlo data analysis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20302321

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1021/JP911533Q

1 reference

release_kz3knsgihfbutlmui74otyvgem

29 July 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/kz3knsgihfbutlmui74otyvgem

24 November 2022

mapped directly with Wikidata item

PMCID

2862262

1 reference

29 July 2017

1 reference

PubMed ID

20302321