Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells. (Q33821960)

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English	Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells.	scientific article

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2 January 2020

Phosphorylation of LKB1 at serine 428 by protein kinase C-zeta is required for metformin-enhanced activation of the AMP-activated protein kinase in endothelial cells (English)

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2 January 2020

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phosphorylation

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inferred from title

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2 January 2020

Dietbert Neumann

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2 January 2020

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Zhonglin Xie

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2 January 2020

Yunzhou Dong

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2 January 2020

Ming-Hui Zou

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4 February 2008

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2 January 2020

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2 January 2020

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2 January 2020

952-962

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2 January 2020

Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response study

1 reference

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28 July 2018

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

1 reference

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28 July 2018

Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase

1 reference

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28 July 2018

The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases

1 reference

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28 July 2018

A novel protocol for the subcellular fractionation of C3A hepatoma cells using sucrose density gradient centrifugation

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28 July 2018

Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.

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28 July 2018

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

1 reference

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28 July 2018

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

1 reference

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28 July 2018

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

1 reference

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28 July 2018

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

1 reference

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28 July 2018

Management of cellular energy by the AMP-activated protein kinase system

1 reference

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28 July 2018

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

1 reference

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28 July 2018

AMP-activated protein kinase, super metabolic regulator

1 reference

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28 July 2018

Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

1 reference

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28 July 2018

The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism

1 reference

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28 July 2018

Metformin Increases AMP-Activated Protein Kinase Activity in Skeletal Muscle of Subjects With Type 2 Diabetes

1 reference

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28 July 2018

Leptin activates cardiac fatty acid oxidation independent of changes in the AMP-activated protein kinase-acetyl-CoA carboxylase-malonyl-CoA axis

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28 July 2018

Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1).

1 reference

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28 July 2018

The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

1 reference

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28 July 2018

Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

1 reference

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28 July 2018

LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1

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28 July 2018

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

1 reference

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28 July 2018

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

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28 July 2018

The regulation of AMP-activated protein kinase by phosphorylation

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28 July 2018

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

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28 July 2018

Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest

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28 July 2018

Cellular distribution and developmental expression of AMP-activated protein kinase isoforms in mouse central nervous system

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28 July 2018

The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?

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28 July 2018

Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

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28 July 2018

AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform.

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28 July 2018

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

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28 July 2018

The AMP-activated protein kinase--fuel gauge of the mammalian cell?

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28 July 2018

Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

1 reference

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28 July 2018

Metformin improves hemodynamic and rheological responses to L-arginine in NIDDM patients.

1 reference

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28 July 2018

Vascular effects of metformin. Possible mechanisms for its antihypertensive action in the spontaneously hypertensive rat.

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28 July 2018

Mammalian AMP-activated protein kinase subfamily

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28 July 2018

Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase

1 reference

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29 October 2018

Activation of protein kinase C zeta by peroxynitrite regulates LKB1-dependent AMP-activated protein kinase in cultured endothelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862466

29 October 2018

Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO4)3 in muscle of diabetic subjects

1 reference

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29 October 2018

Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

1 reference

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29 October 2018

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

1 reference

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29 October 2018

Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.

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29 October 2018

New application of a subcellular fractionation method to kidney and testis for the determination of conjugated linoleic acid in selected cell organelles of healthy and cancerous human tissues

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29 October 2018

Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species

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29 October 2018

Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus

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29 October 2018

Activation of 5'-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells. Role of peroxynitrite.

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29 October 2018

Modulation by peroxynitrite of Akt- and AMP-activated kinase-dependent Ser1179 phosphorylation of endothelial nitric oxide synthase.

1 reference

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29 October 2018

Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-beta-D-riboside (AICAR)-stimulated glucose transport

1 reference

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29 October 2018

Role of AMP-activated protein kinase in mechanism of metformin action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862466

29 October 2018

Metformin treatment corrects vascular insulin resistance in hypertension.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862466

29 October 2018

Metformin improves vascular function in insulin-resistant rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862466

29 October 2018

Loss of cytoplasmic retention ability of mutant LKB1 found in Peutz-Jeghers syndrome patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/18250273

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute sympathoinhibitory actions of metformin in spontaneously hypertensive rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18250273

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1161/CIRCULATIONAHA.107.744490

1 reference

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2 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18250273%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

1 reference

Europe PubMed Central

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2 January 2020

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