A novel molecular mechanism of dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors. (Q33826904)

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19 January 2020

title

A novel molecular mechanism of dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors (English)

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19 January 2020

3

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19 January 2020

author name string

Galina N Nikolenko

series ordinal

1

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19 January 2020

Krista A Delviks-Frankenberry

series ordinal

2

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19 January 2020

publication date

10 March 2010

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19 January 2020

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19 January 2020

volume

84

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19 January 2020

issue

10

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19 January 2020

page(s)

5238-5249

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Subtype-specific differences in the human immunodeficiency virus type 1 reverse transcriptase connection subdomain of CRF01_AE are associated with higher levels of resistance to 3'-azido-3'-deoxythymidine.

19 January 2020

cites work

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4 July 2018

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4 July 2018

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HIV-1 reverse transcriptase connection subdomain mutations reduce template RNA degradation and enhance AZT excision

4 July 2018

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Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3'-azido-3'-deoxythymidine through both RNase H-dependent and -independent mechanisms

4 July 2018

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Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants

4 July 2018

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4 July 2018

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Amino acid mutation N348I in the connection subdomain of human immunodeficiency virus type 1 reverse transcriptase confers multiclass resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors

4 July 2018

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N348I in the connection domain of HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance

4 July 2018

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Mechanisms by which the G333D mutation in human immunodeficiency virus type 1 Reverse transcriptase facilitates dual resistance to zidovudine and lamivudine

4 July 2018

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Probing nonnucleoside inhibitor-induced active-site distortion in HIV-1 reverse transcriptase by transient kinetic analyses

4 July 2018

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Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3'-azido-3'-dideoxythymidine.

4 July 2018

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Mutations in human immunodeficiency virus type 1 RNase H primer grip enhance 3'-azido-3'-deoxythymidine resistance

4 July 2018

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Mutations in the connection domain of HIV-1 reverse transcriptase increase 3'-azido-3'-deoxythymidine resistance

4 July 2018

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Dimerization of human immunodeficiency virus type 1 reverse transcriptase as an antiviral target.

4 July 2018

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The HIV-1 reverse transcriptase mutants G190S and G190A, which confer resistance to non-nucleoside reverse transcriptase inhibitors, demonstrate reductions in RNase H activity and DNA synthesis from tRNA(Lys, 3) that correlate with reductions in rep

4 July 2018

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TMC125 displays a high genetic barrier to the development of resistance: evidence from in vitro selection experiments

4 July 2018

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Mechanism for nucleoside analog-mediated abrogation of HIV-1 replication: balance between RNase H activity and nucleotide excision

4 July 2018

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4 July 2018

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Gln145Met/Leu changes in human immunodeficiency virus type 1 reverse transcriptase confer resistance to nucleoside and nonnucleoside analogs and impair virus replication.

4 July 2018

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4 July 2018

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Antiretroviral drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase increase template-switching frequency

4 July 2018

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Structural and biochemical effects of human immunodeficiency virus mutants resistant to non-nucleoside reverse transcriptase inhibitors

4 July 2018

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4 July 2018

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Mutation of amino acids in the connection domain of human immunodeficiency virus type 1 reverse transcriptase that contact the template-primer affects RNase H activity.

4 July 2018

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4 July 2018

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4 July 2018

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Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture

4 July 2018

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4 July 2018

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A novel polymorphism at codon 333 of human immunodeficiency virus type 1 reverse transcriptase can facilitate dual resistance to zidovudine and L-2',3'-dideoxy-3'-thiacytidine

4 July 2018

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Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor

4 July 2018

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4 July 2018

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A drug resistance mutation in the inhibitor binding pocket of human immunodeficiency virus type 1 reverse transcriptase impairs DNA synthesis and RNA degradation

4 July 2018

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Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization

4 July 2018

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A general method for the generation of high-titer, pantropic retroviral vectors: highly efficient infection of primary hepatocytes

4 July 2018

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Nevirapine alters the cleavage specificity of ribonuclease H of human immunodeficiency virus 1 reverse transcriptase

4 July 2018

1 reference

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Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors.

4 July 2018

1 reference

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Effect of a thiobenzimidazolone derivative on DNA strand transfer catalyzed by HIV-1 reverse transcriptase

4 July 2018

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Specific targeting of highly conserved residues in the HIV-1 reverse transcriptase primer grip region. 2. Stereoselective interaction to overcome the effects of drug resistant mutations

4 July 2018

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Phenotypic impact of resistance mutations on etravirine susceptibility in HIV patients with prior failure to nonnucleoside analogues

29 October 2018

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Prevalence of etravirine-associated mutations in clinical samples with resistance to nevirapine and efavirenz.

29 October 2018

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Impact of residues in the nonnucleoside reverse transcriptase inhibitor binding pocket on HIV-1 reverse transcriptase heterodimer stability

29 October 2018

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Efavirenz accelerates HIV-1 reverse transcriptase ribonuclease H cleavage, leading to diminished zidovudine excision

29 October 2018

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NNRTI-selected mutations at codon 190 of human immunodeficiency virus type 1 reverse transcriptase decrease susceptibility to stavudine and zidovudine.

29 October 2018

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Dissecting the effects of DNA polymerase and ribonuclease H inhibitor combinations on HIV-1 reverse-transcriptase activities

29 October 2018

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Nevirapine-selected mutations Y181I/C of HIV-1 reverse transcriptase confer cross-resistance to stavudine

29 October 2018

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Detection of a new HIV-1 reverse transcriptase mutation (Q145M) conferring resistance to nucleoside and non-nucleoside inhibitors in a patient failing highly active antiretroviral therapy.

29 October 2018

1 reference

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Nevirapine resistance mutation at codon 181 of the HIV-1 reverse transcriptase confers stavudine resistance by increasing nucleotide substrate discrimination and phosphorolytic activity.

29 October 2018

1 reference

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Altering the RNase H primer grip of human immunodeficiency virus reverse transcriptase modifies cleavage specificity

29 October 2018

1 reference

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The Y181C mutant of HIV-1 reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors alters the size distribution of RNase H cleavages

29 October 2018

1 reference

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Resistance to nevirapine of HIV-1 reverse transcriptase mutants: loss of stabilizing interactions and thermodynamic or steric barriers are induced by different single amino acid substitutions.

29 October 2018

1 reference

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Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 V

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2863829

HIV-1 reverse transcriptase resistance to nonnucleoside inhibitors

29 October 2018

1 reference

12 December 2020

Mutations within the primer grip region of HIV-1 reverse transcriptase result in loss of RNase H function

1 reference

12 December 2020

Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs)

1 reference

12 December 2020

HIV-1 reverse transcriptase plus-strand initiation exhibits preferential sensitivity to non-nucleoside reverse transcriptase inhibitors in vitro

1 reference

12 December 2020

Identifiers

DOI

10.1128/JVI.01545-09

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20219933%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20219933%20AND%20SRC:MED&resulttype=core&format=json

19 January 2020

PubMed publication ID

20219933

1 reference