The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling (Q33828931)

29 July 2017

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title

The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling (English)

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29 July 2017

F Vazquez

1

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PubMed ID

10656987

29 July 2017

W R Sellers

series ordinal

2

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PubMed ID

10656987

29 July 2017

language of work or name

English

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publication date

1 February 2000

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Biochimica et Biophysica Acta

29 July 2017

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29 July 2017

1470

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29 July 2017

M21-35

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29 July 2017

1

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Phosphoinositide kinases

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Phosphatidylinositol phosphate kinases, a multifaceted family of signaling enzymes.

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Phosphatidylinositol 3-kinase

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Ras signalling and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Phosphoinositide binding domains: embracing 3-phosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Mechanisms and consequences of activation of protein kinase B/Akt

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Phosphorylation of serine 256 by protein kinase B disrupts transactivation by FKHR and mediates effects of insulin on insulin-like growth factor-binding protein-1 promoter activity through a conserved insulin response sequence

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Direct control of the Forkhead transcription factor AFX by protein kinase B

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Regulation of cell death protease caspase-9 by phosphorylation

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Negative regulation of the forkhead transcription factor FKHR by Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Induction of NF-kappaB by the Akt/PKB kinase

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

p70s6k function is essential for G1 progression

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Phosphorylation and activation of p70s6k by PDK1

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Phospholipase C-gamma 1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Cyclin D Expression Is Controlled Post-transcriptionally via a Phosphatidylinositol 3-Kinase/Akt-dependent Pathway

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Multiple ras effector pathways contribute to G(1) cell cycle progression

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Pten is essential for embryonic development and tumour suppression

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Interleukin 3-dependent survival by the Akt protein kinase

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Activated phosphatidylinositol 3-kinase and Akt kinase promote survival of superior cervical neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Integrins and anoikis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Aging, life span, and senescence

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https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Role of the retinoblastoma protein in the pathogenesis of human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

The retinoblastoma protein and cell cycle control

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

PIK3CA is implicated as an oncogene in ovarian cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Molecular alterations of the AKT2 oncogene in ovarian and breast carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Fusion of a fork head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

The PAX3-FKHR fusion protein created by the t(2;13) translocation in alveolar rhabdomyosarcomas is a more potent transcriptional activator than PAX3

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

The Pax3-FKHR oncoprotein is unresponsive to the Pax3-associated repressor hDaxx

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

The mRNA 5' cap-binding protein eIF4E and control of cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

The genetic basis of Cowden's syndrome: three novel mutations in PTEN/MMAC1/TEP1.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Germline mutations in PTEN are present in Bannayan-Zonana syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

PTEN mutations in gliomas and glioneuronal tumors.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

PTEN1 is frequently mutated in primary endometrial carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Inactivation of the PTEN/MMAC1/TEP1 gene in human lung cancers.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Mutation analysis of the PTEN/MMAC1 gene in lung cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Somatic mutations of the PTEN tumor suppressor gene in sporadic follicular thyroid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Allelic loss of chromosome 10q23 is associated with tumor progression in breast carcinomas.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

CREB is a regulatory target for the protein kinase Akt/PKB

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

The Akt kinase signals directly to endothelial nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-419X%2899%2900032-3

7 January 2021

10.1016/S0304-419X(99)00032-3

Identifiers

DOI

1 reference

29 July 2017

1 reference

PubMed ID

10656987