Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity. (Q33835200)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24821781%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

title

Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24821781%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

1 reference

1

1 reference

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18 March 2020

Keisuke Horikawa

3

1 reference

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18 March 2020

David Langley

7

1 reference

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18 March 2020

Romain Rouet

10

1 reference

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18 March 2020

Deborah K Dunn-Walters

14

1 reference

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18 March 2020

Daniel Christ

15

1 reference

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18 March 2020

Chris Goodnow

16

1 reference

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18 March 2020

author name string

Emily Spierings

4

1 reference

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18 March 2020

David Kipling

5

1 reference

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18 March 2020

Katrina L Randall

6

1 reference

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18 March 2020

Brendan Roome

8

1 reference

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18 March 2020

Rodrigo Vazquez-Lombardi

9

1 reference

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18 March 2020

Jana Hermes

11

1 reference

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18 March 2020

Tyani D Chan

12

1 reference

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18 March 2020

Robert Brink

13

1 reference

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18 March 2020

Peter R Schofield

2

1 reference

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18 March 2020

language of work or name

English

0 references

publication date

12 May 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24821781%20AND%20SRC:MED&resulttype=core&format=json

Proceedings of the National Academy of Sciences of the United States of America

18 March 2020

published in

1 reference

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18 March 2020

volume

111

1 reference

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18 March 2020

issue

25

1 reference

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18 March 2020

page(s)

E2567-75

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24821781%20AND%20SRC:MED&resulttype=core&format=json

Molecular basis of 9G4 B cell autoreactivity in human systemic lupus erythematosus

18 March 2020

cites work

1 reference

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Induction of HIV-1 broad neutralizing antibodies in 2F5 knock-in mice: selection against membrane proximal external region-associated autoreactivity limits T-dependent responses

4 July 2018

1 reference

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Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10

4 July 2018

1 reference

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Primary antibody deficiencies

4 July 2018

1 reference

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Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen.

4 July 2018

1 reference

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Endogenous antigen tunes the responsiveness of naive B cells but not T cells

4 July 2018

1 reference

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The relationship between CD27 negative and positive B cell populations in human peripheral blood

4 July 2018

1 reference

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Rescue of HIV-1 broad neutralizing antibody-expressing B cells in 2F5 VH x VL knockin mice reveals multiple tolerance controls

4 July 2018

1 reference

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Anergic responses characterize a large fraction of human autoreactive naive B cells expressing low levels of surface IgM.

4 July 2018

1 reference

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Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection

4 July 2018

1 reference

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Capturing the natural diversity of the human antibody response against vaccinia virus

4 July 2018

1 reference

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Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter

4 July 2018

1 reference

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Control systems and decision making for antibody production.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

PI3 kinase signals BCR-dependent mature B cell survival

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Light chain somatic mutations change thermodynamics of binding and water coordination in the HyHEL-10 family of antibodies

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

EBI2 mediates B cell segregation between the outer and centre follicle

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Structural insights into what glycan arrays tell us about how glycan-binding proteins interact with their ligands

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Functional anergy in a subpopulation of naive B cells from healthy humans that express autoreactive immunoglobulin receptors.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Anti-D and anti-i activities are inseparable in V4-34-encoded monoclonal anti-D: the same framework 1 residues are required for both reactivities

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

High affinity germinal center B cells are actively selected into the plasma cell compartment.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Antiviral antibody responses: the two extremes of a wide spectrum

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Controlling N-linked glycan site occupancy

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Human immunoglobulin selection associated with class switch and possible tolerogenic origins for C delta class-switched B cells

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

The somatic generation of immune recognition

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Predominant autoantibody production by early human B cell precursors

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Antibody domain exchange is an immunological solution to carbohydrate cluster recognition

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigen

4 July 2018

1 reference

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Structural evidence for entropic contribution of salt bridge formation to a protein antigen-antibody interaction: the case of hen lysozyme-HyHEL-10 Fv complex

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Relative roles of somatic and Darwinian evolution in shaping the antibody response

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Antigen-induced B-cell death and elimination during germinal-centre immune responses

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Attachment of carbohydrate to the variable region of myeloma immunoglobulin light chains

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Sequential changes in the relative affinity of antibodies synthesized during the immune response

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Asymmetrically glycosylated IgG isolated from non-immune human sera

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Primary antibody-forming cells and secondary B cells are generated from separate precursor cell subpopulations.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Antibody variable region glycosylation: position effects on antigen binding and carbohydrate structure

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies. Evidence for affinity maturation by somatic hypermutation and repertoire shift

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Theoretical studies of clonal selection: Minimal antibody repertoire size and reliability of self-non-self discrimination

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Inherited Immunoglobulin Idiotypes of the Mouse

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4078846

Tracking of the V4-34 (VH4-21) gene in human tonsil reveals clonal isotype switch events and a highly variable degree of somatic hypermutation.

4 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1406974111

Infant and adult human B cell responses to rotavirus share common immunodominant variable gene repertoires.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1406974111

Limits for antibody affinity maturation and repertoire diversification in hypervaccinated humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1406974111

Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1406974111

Structural plasticity and the evolution of antibody affinity and specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1406974111

Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1406974111

Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1406974111

How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1406974111

Bcl-2 obstructs negative selection of autoreactive, hypermutated antibody V regions during memory B cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1406974111

Effect of somatic hypermutation on potential N-glycosylation sites in human immunoglobulin heavy chain variable regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1406974111

Molecular events during maturation of the immune response to oxazolone

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1406974111

Induction of self-tolerance in mature peripheral B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1406974111

Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24821781

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cold agglutinin activity is common among human monoclonal IgM Rh system antibodies using the V4-34 heavy chain variable gene segment

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24821781

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The carbohydrate contents of fragments and polypeptide chains of human gamma-G-myeloma proteins of different heavy-chain subclasses

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24821781

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1406974111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24821781%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24821781%20AND%20SRC:MED&resulttype=core&format=json

18 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24821781%20AND%20SRC:MED&resulttype=core&format=json