Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies. Evidence for affinity maturation by somatic hypermutation and repertoire shift (Q41022184)

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scientific article published on December 1, 1992

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English	Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies. Evidence for affinity maturation by somatic hypermutation and repertoire shift	scientific article published on December 1, 1992

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scholarly article

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Europe PubMed Central

PMC publication ID

25 September 2017

Germline variable region gene segment derivation of human monoclonal anti-Rh(D) antibodies. Evidence for affinity maturation by somatic hypermutation and repertoire shift (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1469099

29 September 2022

Gene Rearrangement, B-Lymphocyte, Heavy Chain

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1469099

29 September 2022

Gene Rearrangement, B-Lymphocyte, Light Chain

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A1469099

29 September 2022

immunoglobulin genes

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29 September 2022

author name string

Hughes-Jones NC

7

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25 September 2017

J. M. Bye

1

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29 September 2022

C. Carter

2

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29 September 2022

Y. Cui

3

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29 September 2022

B. D. Gorick

4

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29 September 2022

S. Songsivilai

5

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29 September 2022

G. Winter

6

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29 September 2022

N. C. Hughes-Jones

7

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29 September 2022

J. D. Marks

8

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29 September 2022

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publication date

1 December 1992

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25 September 2017

full work available at URL

https://europepmc.org/articles/PMC443405

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Europe PubMed Central

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Europe PubMed Central

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29 September 2022

https://europepmc.org/articles/PMC443405?pdf=render

Portable Document Format

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29 September 2022

Journal of Clinical Investigation

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25 September 2017

90

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Europe PubMed Central

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25 September 2017

6

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Europe PubMed Central

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25 September 2017

2481-2490

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

Organization and evolution of immunoglobulin VH gene subgroups

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Human immunoglobulin variable region genes--DNA sequences of two V kappa genes and a pseudogene

1 reference

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26 September 2017

A comprehensive set of sequence analysis programs for the VAX

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Immunoglobulin genes of different subgroups are interdigitated within the VK locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Evolution of immunoglobulin V genes: evidence indicating that recently duplicated human V kappa sequences have diverged by gene conversion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Evolution of human immunoglobulin kappa J region genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

The isolation of a human Ig Vλ gene from a recombinant library of chromosome 22 and estimation of its copy number

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Composite human VKgenes and a model of their evolution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Aberrant recombination events in B cell lines derived from a kappa-deficient human

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Mutation drift and repertoire shift in the maturation of the immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Organization of human immunoglobulin heavy chain diversity gene loci

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

The molecular genetics of the arsonate idiotypic system of A/J mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Isolation and characterization of a light chain variable region gene for human rheumatoid factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

A novel family of variable region genes of the human immunoglobulin heavy chain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Isolation and characterization of human VkIII germ-line genes. Implications for the molecular basis of human VkIII light chain diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Human lambda light chain locus: organization and DNA sequences of three genomic J regions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Genetic basis for the cross-reactive idiotypes on the light chains of human IgM anti-IgG autoantibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Subgroup IV of human immunoglobulin K light chains is encoded by a single germline gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Human immunoglobulin kappa light chain genes of subgroups II and III

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

The smaller human VH gene families display remarkably little polymorphism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

A natural autoantibody is encoded by germline heavy and lambda light chain variable region genes without somatic mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

First nucleotide sequence of a human immunoglobulin variable lambda gene belonging to subgroup II

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

First genomic sequence of a human Ig variable lambda gene belonging to subgroup I. Functional genes, pseudogenes and vestigial sequences are interspersed in the IGLV locus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

A member of a novel human DH gene family: DHFL16.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

The complete nucleotide sequences of the heavy chain variable regions of six monospecific rheumatoid factors derived from Epstein-Barr virus-transformed B cells isolated from the synovial tissue of patients with rheumatoid arthritis. Further evidenc

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

The physical organization of the human immunoglobulin heavy chain gene complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Genomic sequence of IGLV1S2, a human immunoglobulin variable lambda gene belonging to subgroup I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

First genomic sequence of a human Ig variable lambda gene belonging to subgroup III.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Structure and expression of the human immunoglobulin lambda genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Organization of variable region segments of the human immunoglobulin heavy chain: duplication of the D5 cluster within the locus and interchromosomal translocation of variable region segments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Nucleotide sequences and three-dimensional modelling of the VH and VL domains of two human monoclonal antibodies specific for the D antigen of the human Rh-blood-group system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Molecular biology of the Rh antigens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Mutation and selection during the secondary response to 2-phenyloxazolone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

V lambda and J lambda-C lambda gene segments of the human immunoglobulin lambda light chain locus are separated by 14 kb and rearrange by a deletion mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Preferential utilization of specific immunoglobulin heavy chain diversity and joining segments in adult human peripheral blood B lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Molecular basis of an autoantibody-associated restriction fragment length polymorphism that confers susceptibility to autoimmune diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

A deletion map of the human immunoglobulin heavy chain variable region

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Restriction of human immune antibodies to heavy-chain variable subgroups

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

26 September 2017

Transcription maps of polyoma virus-specific RNA: analysis by two-dimensional nuclease S1 gel mapping.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

14 June 2018

Organization and evolution of a gene cluster for human immunoglobulin variable regions of the kappa type

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

14 June 2018

A limited number of B cell lineages generates the heterogeneity of a secondary immune response.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

14 June 2018

The use of chromosomal translocations to study human immunoglobulin gene organization: mapping DH segments within 35 kb of the C mu gene and identification of a new DH locus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

14 June 2018

Two unusual human immunoglobulin V kappa genes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

14 June 2018

Requirements for the establishment of heterohybridomas secreting monoclonal human antibody to rhesus (D) blood group antigen.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

14 June 2018

Nucleotide sequences of eight human natural autoantibody VH regions reveals apparent restricted use of VH families.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

14 June 2018

Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

14 June 2018

Structural analyses of human developmentally regulated Vh3 genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

14 June 2018

Nucleotide sequence of a human monoclonal anti-idiotypic antibody specific for a rabies virus-neutralizing monoclonal idiotypic antibody reveals extensive somatic variability suggestive of an antigen-driven immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

14 June 2018

The V kappa gene repertoire in the human germ line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

14 June 2018

Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. IV. The less frequently expressed VL are heterogeneous.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

14 June 2018

The human immunoglobulin kappa locus. Characterization of the duplicated O regions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

14 June 2018

Kinetic maturation of an immune response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

14 June 2018

Somatic mutations in the variable regions of a human IgG anti-double-stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus

1 reference

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14 June 2018

Ig repertoire of human polyspecific antibodies and B cell ontogeny

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

14 June 2018

Human monoclonal antibodies against blood group antigens preferentially express a VH4-21 variable region gene-associated epitope

1 reference

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14 June 2018

Human immunoglobulin VH and VK repertoire revealed by in situ hybridization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

14 June 2018

Human immunoglobulin D segments encoded in tandem multigenic families

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=443405

19 August 2018

Multiple Epitopes Recognised by Human Monoclonal IgM Anti-D Antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/1469099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity in the ability of IgG1 monoclonal anti-D to promote lymphocyte-mediated red cell lysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/1469099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clonal characterization of the human IgG antibody repertoire to Haemophilus influenzae type b polysaccharide. III. A single VKII gene and one of several JK genes are joined by an invariant arginine to form the most common L chain V region

1 reference

https://pubmed.ncbi.nlm.nih.gov/1469099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Organization and evolution of variable region genes of the human immunoglobulin heavy chain

1 reference

https://pubmed.ncbi.nlm.nih.gov/1469099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

At least five DH genes of human immunoglobulin heavy chains are encoded in 9-kilobase DNA fragments

1 reference

https://pubmed.ncbi.nlm.nih.gov/1469099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human immunoglobulin D segments: isolation of a new D segment and polymorphic deletion of the D1 segment

1 reference

https://pubmed.ncbi.nlm.nih.gov/1469099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of primary anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in normal and idiotypically suppressed C57BL/6 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/1469099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A large section of the gene locus encoding human immunoglobulin variable regions of the kappa type is duplicated

1 reference

https://pubmed.ncbi.nlm.nih.gov/1469099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family-specific oligonucleotide probes

1 reference

https://pubmed.ncbi.nlm.nih.gov/1469099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three epitopes on the human Rh antigen D recognized by 125I-labelled human monoclonal IgG antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/1469099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural characterization of human monoclonal cold agglutinins: evidence for a distinct primary sequence-defined VH4 idiotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/1469099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The human VK locus. Characterization of a duplicated region encoding 28 different immunoglobulin genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/1469099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular events during maturation of the immune response to oxazolone

1 reference

https://pubmed.ncbi.nlm.nih.gov/1469099

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI116140

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

25 September 2017

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