Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27. (Q33837015)

29 July 2017

title

Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27. (English)

1 reference

29 July 2017

Volker H Haase

4

0 references

author name string

Fiona A Mack

1

1 reference

29 July 2017

Jagruti H Patel

2

1 reference

29 July 2017

Mangatt P Biju

3

1 reference

29 July 2017

M Celeste Simon

5

1 reference

29 July 2017

language of work or name

English

0 references

publication date

1 June 2005

1 reference

Molecular and Cellular Biology

29 July 2017

published in

1 reference

29 July 2017

volume

25

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29 July 2017

issue

11

1 reference

29 July 2017

page(s)

4565-4578

1 reference

HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.

29 July 2017

cites work

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Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene

4 July 2018

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Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors.

4 July 2018

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Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth

4 July 2018

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Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha

4 July 2018

1 reference

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Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth

4 July 2018

1 reference

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Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL.

4 July 2018

1 reference

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Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia

4 July 2018

1 reference

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Cell attachment to the extracellular matrix induces proteasomal degradation of p21(CIP1) via Cdc42/Rac1 signaling

4 July 2018

1 reference

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VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells.

4 July 2018

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Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription

4 July 2018

1 reference

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Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival

4 July 2018

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The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.

4 July 2018

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HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.

4 July 2018

1 reference

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HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation

4 July 2018

1 reference

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

4 July 2018

1 reference

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

4 July 2018

1 reference

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Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

4 July 2018

1 reference

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p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest

4 July 2018

1 reference

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Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

4 July 2018

1 reference

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Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

4 July 2018

1 reference

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The role of ARNT2 in tumor angiogenesis and the neural response to hypoxia

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140627

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140627

The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140627

The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140627

Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140627

Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140627

Cellular transformation and malignancy induced by ras require c-jun

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140627

Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140627

Somatic mutations of the von Hippel-Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140627

Tumour suppression by the human von Hippel-Lindau gene product

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140627

Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140627

The hypoxic response of tumors is dependent on their microenvironment.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140627

Loss of von Hippel-Lindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140627

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140627

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140627

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140627

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140627

Investigation of c-myc and K-ras amplification in renal clear cell adenocarcinoma.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1140627

von Hippel-Lindau disease

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15899860

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

von Hippel-Lindau protein promotes the assembly of actin and vinculin and inhibits cell motility

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15899860

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hypoxia inhibits G1/S transition through regulation of p27 expression

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/15899860

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.25.11.4565-4578.2005

1 reference

29 July 2017

1 reference

29 July 2017

1 reference