Manipulating antigenic ligand strength to selectively target myelin-reactive CD4+ T cells in EAE. (Q33838467)

29 July 2017

1 reference

title

Manipulating antigenic ligand strength to selectively target myelin-reactive CD4+ T cells in EAE. (English)

1 reference

29 July 2017

Joseph J Sabatino

1

1 reference

29 July 2017

Kristen M Rosenthal

series ordinal

2

1 reference

29 July 2017

Brian D Evavold

series ordinal

3

1 reference

29 July 2017

publication date

11 November 2009

1 reference

Journal of Neuroimmune Pharmacology

29 July 2017

published in

1 reference

29 July 2017

volume

5

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29 July 2017

issue

2

1 reference

29 July 2017

page(s)

176-188

1 reference

Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1.

29 July 2017

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T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Activation thresholds determine susceptibility to peptide-induced tolerance in a heterogeneous myelin-reactive T cell repertoire

5 July 2018

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Modification of peptide interaction with MHC creates TCR partial agonists

5 July 2018

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5 July 2018

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5 July 2018

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Epitope dominance, competition and T cell affinity maturation

5 July 2018

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Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

5 July 2018

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Reduced self-reactivity of an autoreactive T cell after activation with cross-reactive non-self-ligand

5 July 2018

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c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation

5 July 2018

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Selection and fine-tuning of the autoimmune T-cell repertoire

5 July 2018

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The enemy within: keeping self-reactive T cells at bay in the periphery

5 July 2018

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Dissociation of peripheral T cell responses from thymocyte negative selection by weak agonists supports a spare receptor model of T cell activation

5 July 2018

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5 July 2018

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T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire

5 July 2018

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Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength

5 July 2018

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T-cell activation by soluble MHC oligomers can be described by a two-parameter binding model

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide

5 July 2018

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Structural and functional consequences of altering a peptide MHC anchor residue

5 July 2018

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5 July 2018

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Distinct T cell interactions with HLA class II tetramers characterize a spectrum of TCR affinities in the human antigen-specific T cell response

5 July 2018

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T cell receptor (TCR)-mediated repertoire selection and loss of TCR vbeta diversity during the initiation of a CD4(+) T cell response in vivo

5 July 2018

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Determination of the relationship between T cell responsiveness and the number of MHC-peptide complexes using specific monoclonal antibodies

5 July 2018

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High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire

5 July 2018

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5 July 2018

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5 July 2018

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The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds.

5 July 2018

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The stimulation of low-affinity, nontolerized clones by heteroclitic antigen analogues causes the breaking of tolerance established to an immunodominant T cell epitope

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Identification of high potency microbial and self ligands for a human autoreactive class II-restricted T cell clone

5 July 2018

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Induction of apoptosis and T helper 2 (Th2) responses correlates with peptide affinity for the major histocompatibility complex in self-reactive T cell receptor transgenic mice

5 July 2018

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Late complications of immune deviation therapy in a nonhuman primate

5 July 2018

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Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse V beta gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor V beta b and T cell r

5 July 2018

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Treatment of autoimmune disease by oral tolerance to autoantigens

5 July 2018

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Lack of SHPTP1 results in src-family kinase hyperactivation and thymocyte hyperresponsiveness

5 July 2018

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Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Essential flexibility in the T-cell recognition of antigen

5 July 2018

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Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells

5 July 2018

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Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

5 July 2018

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Antigen-induced programmed T cell death as a new approach to immune therapy

5 July 2018

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Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness

5 July 2018

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T cell receptor antagonists and partial agonists

5 July 2018

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Specific T cell recognition of minimally homologous peptides: evidence for multiple endogenous ligands

5 July 2018

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Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production

5 July 2018

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T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis

5 July 2018

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Successful prevention and treatment of autoimmune encephalomyelitis by short-term administration of anti-T-cell receptor alpha beta antibody.

5 July 2018

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"Viable motheaten," a new allele at the motheaten locus. I. Pathology

5 July 2018

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Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy.

5 July 2018

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The minimal number of class II MHC-antigen complexes needed for T cell activation

5 July 2018

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Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

5 July 2018

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Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

5 July 2018

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A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis

5 July 2018

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Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

5 July 2018

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Cross-reactive antigen recognition by an encephalitogenic T cell receptor. Implications for T cell biology and autoimmunity

5 July 2018

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Disease inhibition by major histocompatibility complex binding peptide analogues of disease-associated epitopes: more than blocking alone

5 July 2018

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Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs

5 July 2018

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Analysis of autoreactive CD4 T cells in experimental autoimmune encephalomyelitis after primary and secondary challenge using MHC class II tetramers

5 July 2018

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Expression of the tyrosine phosphatase SRC homology 2 domain-containing protein tyrosine phosphatase 1 determines T cell activation threshold and severity of experimental autoimmune encephalomyelitis.

21 January 2018

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Regulation of polyclonal T cell responses by an MHC anchor-substituted variant of myelin oligodendrocyte glycoprotein 35-55.

21 January 2018

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Cutting edge: dependence of TCR antagonism on Src homology 2 domain-containing protein tyrosine phosphatase activity

21 January 2018

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TCR reserve: a novel principle of CD4 T cell activation by weak ligands

21 January 2018

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MHC variant peptide-mediated anergy of encephalitogenic T cells requires SHP-1.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11481-009-9181-3

T Cell Tolerance Based on Avidity Thresholds Rather Than Complete Deletion Allows Maintenance of Maximal Repertoire Diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-009-9181-3

Feedback control of T-cell receptor activation.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866818

Low-avidity recognition by CD4+ T cells directed to self-antigens

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866818

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866818

Direct observation of ligand recognition by T cells.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866818

Low expression of interferon-stimulated genes in active multiple sclerosis is linked to subnormal phosphorylation of STAT1.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866818

Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866818

Tracing and characterization of the low-avidity self-specific T cell repertoire.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866818

Involvement of the SHP-1 tyrosine phosphatase in regulation of T cell selection

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866818

Termination of peripheral tolerance to a T cell epitope by heteroclitic antigen analogues.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866818

Ligand recognition by alpha beta T cell receptors

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866818

Posttranslational regulation of TCR Valpha allelic exclusion during T cell differentiation.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866818

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866818

Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866818

Low avidity recognition of self-antigen by T cells permits escape from central tolerance.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866818

Mature CD4+ T Cells Perceive a Positively Selecting Class II MHC/Peptide Complex in the Periphery

29 October 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11481-009-9181-3

Class II major histocompatibility complex-peptide tetramer staining in relation to functional avidity and T cell receptor diversity in the mouse CD4+ T cell response to a rheumatoid arthritis-associated antigen

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866818

TCR affinity and negative regulation limit autoimmunity

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866818

Induction of a non-encephalitogenic type 2 T helper-cell autoimmune responsein multiple sclerosis after administration of an altered peptide ligand ina placebo-controlled, randomized phase II trial

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2866818

Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand

29 October 2018

1 reference

12 December 2020

Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides

1 reference

12 December 2020

T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis

1 reference

12 December 2020

A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire

1 reference

12 December 2020

Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms

1 reference

12 December 2020

Reversal of acute experimental autoimmune encephalomyelitis and prevention of relapses by treatment with a myelin basic protein peptide analogue modified to form long-lived peptide-MHC complexes

1 reference

12 December 2020

An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis

1 reference

12 December 2020

Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties

1 reference

12 December 2020

Fas-mediated death and sensory adaptation limit the pathogenic potential of autoreactive T cells after strong antigenic stimulation

1 reference

12 December 2020

The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance

1 reference

12 December 2020

Anatomy of T cell autoimmunity to myelin oligodendrocyte glycoprotein (MOG): prime role of MOG44F in selection and control of MOG-reactive T cells in H-2b mice

1 reference

12 December 2020

Avoiding autoimmune disease--T cells know their limits

1 reference

12 December 2020

Loss of IFN-gamma enables the expansion of autoreactive CD4+ T cells to induce experimental autoimmune encephalomyelitis by a nonencephalitogenic myelin variant antigen

1 reference

12 December 2020

Induction of anergy by antibody blockade of TCR in myelin oligodendrocyte glycoprotein-specific cells

1 reference

12 December 2020

TCR antagonism by peptide requires high TCR expression

1 reference

12 December 2020

Decrypting the spectrum of antigen-specific T-cell responses: the avidity repertoire of MBP-specific T-cells

1 reference

12 December 2020

An MHC anchor-substituted analog of myelin oligodendrocyte glycoprotein 35-55 induces IFN-gamma and autoantibodies in the absence of experimental autoimmune encephalomyelitis and optic neuritis

1 reference

12 December 2020

Motheaten, an Immunodeficient Mutant of the Mouse: I. Genetics and pathology

1 reference

12 December 2020

Predictable TCR antigen recognition based on peptide scans leads to the identification of agonist ligands with no sequence homology

1 reference

12 December 2020

A very high level of crossreactivity is an essential feature of the T-cell receptor

1 reference

12 December 2020

High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling

1 reference

12 December 2020

A new look at MHC and autoimmune disease

1 reference

12 December 2020

The Src-homology domain 2-bearing protein tyrosine phosphatase-1 inhibits antigen receptor-induced apoptosis of activated peripheral T cells

1 reference

12 December 2020

Induction of T cell anergy by low numbers of agonist ligands

1 reference

12 December 2020

Therapeutic potential of TCR antagonists is determined by their ability to modulate a diverse repertoire of autoreactive T cells

1 reference

12 December 2020

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand

1 reference

12 December 2020

Detection of autoreactive T cells in H-2u mice using peptide-MHC multimers

1 reference

12 December 2020

Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion

1 reference

12 December 2020

TCR avidity: it's not how strong you make it, it's how you make it strong

1 reference

12 December 2020

The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model

1 reference

12 December 2020

10.1007/S11481-009-9181-3

Identifiers

DOI

1 reference

Dimensions Publication ID

29 July 2017

0 references

1 reference

29 July 2017

1 reference