Peptide-based immunotherapy of autoimmunity: a path of puzzles, paradoxes and possibilities (Q34567730)

3 August 2017

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title

Peptide-based immunotherapy of autoimmunity: a path of puzzles, paradoxes and possibilities (English)

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3 August 2017

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Anderton SM

1

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3 August 2017

publication date

1 December 2001

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3 August 2017

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3 August 2017

volume

104

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3 August 2017

issue

4

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3 August 2017

page(s)

367-376

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Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands

3 August 2017

cites work

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https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Antigen analog-major histocompatibility complexes act as antagonists of the T cell receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Altered peptide ligand-induced partial T cell activation: molecular mechanisms and role in T cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

The dynamics of T cell receptor signaling: complex orchestration and the key roles of tempo and cooperation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Immunological aspects of experimental allergic encephalomyelitis and multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Characterization of a major encephalitogenic T cell epitope in SJL/J mice with synthetic oligopeptides of myelin basic protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

A small number of residues in the class II molecule I-Au confer the ability to bind the myelin basic protein peptide Ac1-11

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Evidence that the autoimmune antigen myelin basic protein (MBP) Ac1-9 binds towards one end of the major histocompatibility complex (MHC) cleft

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Negative selection during the peripheral immune response to antigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

A single amino acid change in a myelin basic protein peptide confers the capacity to prevent rather than induce experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Disease inhibition by major histocompatibility complex binding peptide analogues of disease-associated epitopes: more than blocking alone

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Peptide analogs to pathogenic epitopes of the human acetylcholine receptor alpha subunit as potential modulators of myasthenia gravis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Inhibition of T-cell reactivity to myasthenogenic epitopes of the human acetylcholine receptor by synthetic analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Single amino acid analogs of a myasthenogenic peptide modulate specific T cell responses and prevent the induction of experimental autoimmune myasthenia gravis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Oral administration of a dual analog of two myasthenogenic T cell epitopes down-regulates experimental autoimmune myasthenia gravis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Modulation of cytokine patterns of human autoreactive T cell clones by a single amino acid substitution of their peptide ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

CD4+ T-cell subsets in autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

IL-4, IL-10, IL-13, and TGF-beta from an altered peptide ligand-specific Th2 cell clone down-regulate adoptive transfer of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

A T cell receptor antagonist peptide induces T cells that mediate bystander suppression and prevent autoimmune encephalomyelitis induced with multiple myelin antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Autopathogenic T helper cell type 1 (Th1) and protective Th2 clones differ in their recognition of the autoantigenic peptide of myelin proteolipid protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Reversal of experimental autoimmune encephalomyelitis by a soluble peptide variant of a myelin basic protein epitope: T cell receptor antagonism and reduction of interferon gamma and tumor necrosis factor alpha production

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Specific inhibition of the T-cell response to myelin basic protein by the synthetic copolymer Cop 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Copolymer 1 induces T cells of the T helper type 2 that crossreact with myelin basic protein and suppress experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Multiple sclerosis: comparison of copolymer-1- reactive T cell lines from treated and untreated subjects reveals cytokine shift from T helper 1 to T helper 2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Synthetic amino acid copolymers that bind to HLA-DR proteins and inhibit type II collagen-reactive T cell clones

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Low avidity recognition of self-antigen by T cells permits escape from central tolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Intravenous injection of soluble antigen induces thymic and peripheral T-cells apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Induction of apoptosis and T helper 2 (Th2) responses correlates with peptide affinity for the major histocompatibility complex in self-reactive T cell receptor transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Selective induction of apoptosis in mature T lymphocytes by variant T cell receptor ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

A kinetic basis for T cell receptor repertoire selection during an immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Selection of the T cell repertoire.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60 T cell epitope in rats suppresses both adjuvant arthritis and nonmicrobially induced experimental arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23)

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Mechanisms of central and peripheral T-cell tolerance: lessons from experimental models of multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Regulatory T cells and inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Sustained clinical benefits of glatiramer acetate in relapsing multiple sclerosis patients observed for 6 years. Copolymer 1 Multiple Sclerosis Study Group

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783326

Fine specificity of the myelin-reactive T cell repertoire: implications for TCR antagonism in autoimmunity

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783326

IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783326

Epitope glycosylation plays a critical role for T cell recognition of type II collagen in collagen-induced arthritis.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783326

Experimental autoimmune encephalomyelitis induced with a combination of myelin basic protein and myelin oligodendrocyte glycoprotein is ameliorated by administration of a single myelin basic protein peptide

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783326

Quantitative analysis of peptides from myelin basic protein binding to the MHC class II protein, I-Au, which confers susceptibility to experimental allergic encephalomyelitis.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783326

Dominance and crypticity of T cell antigenic determinants

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783326

T cell determinant structure of myelin basic protein in B10.PL, SJL/J, and their F1S.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783326

Immunological unresponsiveness

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783326

Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783326

Cross-reactive antigen recognition by an encephalitogenic T cell receptor. Implications for T cell biology and autoimmunity

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783326

Immunological aspects of demyelinating diseases

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1783326

Induction of a non-encephalitogenic type 2 T helper-cell autoimmune responsein multiple sclerosis after administration of an altered peptide ligand ina placebo-controlled, randomized phase II trial

27 October 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2567.2001.01324.X

A very high level of crossreactivity is an essential feature of the T-cell receptor

21 January 2018

1 reference

12 December 2020

Altered peptide ligands of islet autoantigen Imogen 38 inhibit antigen specific T cell reactivity in human type-1 diabetes

1 reference

12 December 2020

Bystander suppression of experimental autoimmune encephalomyelitis by T cell lines and clones of the Th2 type induced by copolymer 1

1 reference

12 December 2020

Therapeutic potential of TCR antagonists is determined by their ability to modulate a diverse repertoire of autoreactive T cells

1 reference

12 December 2020

Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10

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12 December 2020

A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor

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12 December 2020

Tuning T cell activation threshold and effector function with cross-reactive peptide ligands

1 reference

12 December 2020

Copolymer 1 inhibits experimental autoimmune uveoretinitis

1 reference

12 December 2020

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand

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12 December 2020

Antigen-specific elimination of T cells induced by oligomerized hemagglutinin (HA) 306-318

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12 December 2020

Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand

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12 December 2020

Separation of T helper 1 clone cytolysis from proliferation and lymphokine production using analog peptides

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12 December 2020

T cell receptor antagonism mediated by interaction between T cell receptor junctional residues and peptide antigen analogues

1 reference

12 December 2020

An autoantigenic T cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance induction

1 reference

12 December 2020

Inhibition of experimental autoimmune encephalomyelitis by inhalation but not oral administration of the encephalitogenic peptide: influence of MHC binding affinity

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12 December 2020

T cell deletion in high antigen dose therapy of autoimmune encephalomyelitis

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12 December 2020

Antigen‐driven tissue‐specific suppression following oral tolerance: Orally administered myelin basic protein suppresses proteolipid protein‐induced experimental autoimmune encephalomyelitis in the SJL mouse

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12 December 2020

A single TCR antagonist peptide inhibits experimental allergic encephalomyelitis mediated by a diverse T cell repertoire

1 reference

12 December 2020

Intranasal administration of retinal antigens suppresses retinal antigen-induced experimental autoimmune uveoretinitis

1 reference

12 December 2020

Reversal of acute experimental autoimmune encephalomyelitis and prevention of relapses by treatment with a myelin basic protein peptide analogue modified to form long-lived peptide-MHC complexes

1 reference

12 December 2020

Affinity for class II MHC determines the extent to which soluble peptides tolerize autoreactive T cells in naive and primed adult mice--implications for autoimmunity

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12 December 2020

Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells

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12 December 2020

Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation of synthetic peptide 184-198 of bovine type II collagen (CII) expressing a dominant T cell epitope

1 reference

12 December 2020

Regulation of house dust mite responses by intranasally administered peptide: transient activation of CD4+ T cells precedes the development of tolerance in vivo

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12 December 2020

Differential activation of human autoreactive T cell clones by altered peptide ligands derived from myelin basic protein peptide (87-99)

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12 December 2020

Amelioration of relapsing experimental autoimmune encephalomyelitis with altered myelin basic protein peptides involves different cellular mechanisms

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12 December 2020

Induction of IL-4-producing CD4+ T cells by antigenic peptides altered for TCR binding

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12 December 2020

Changes in cytokine secretion induced by altered peptide ligands of myelin basic protein peptide 85-99

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12 December 2020

Distinct biochemical signals characterize agonist- and altered peptide ligand-induced differentiation of naive CD4+ T cells into Th1 and Th2 subsets

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12 December 2020

Hierarchy in the ability of T cell epitopes to induce peripheral tolerance to antigens from myelin

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12 December 2020

10.1046/J.1365-2567.2001.01324.X

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DOI

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3 August 2017

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