Nod2 suppresses Borrelia burgdorferi mediated murine Lyme arthritis and carditis through the induction of tolerance (Q33841037)

29 July 2017

Nod2 suppresses Borrelia burgdorferi mediated murine Lyme arthritis and carditis through the induction of tolerance (English)

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29 July 2017

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Tanja Petnicki-Ocwieja

1

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29 July 2017

Alicia S DeFrancesco

2

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29 July 2017

Erin Chung

3

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29 July 2017

Courtney T Darcy

4

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29 July 2017

Roderick T Bronson

5

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29 July 2017

Koichi S Kobayashi

6

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29 July 2017

Linden T Hu

7

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29 July 2017

language of work or name

English

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publication date

28 February 2011

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29 July 2017

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29 July 2017

6

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29 July 2017

2

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29 July 2017

e17414

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Creative Commons Attribution 4.0 International

29 July 2017

start time

28 February 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Human integrin α(3)β(1) regulates TLR2 recognition of lipopeptides from endosomal compartments

28 July 2018

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Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum

28 July 2018

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Recognition of Borrelia burgdorferi by NOD2 is central for the induction of an inflammatory reaction

28 July 2018

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28 July 2018

Lyme disease: a review

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The Lyme disease spirochete Borrelia burgdorferi utilizes multiple ligands, including RNA, for interferon regulatory factor 3-dependent induction of type I interferon-responsive genes

28 July 2018

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NOD2 contributes to the inflammatory responses of primary murine microglia and astrocytes to Staphylococcus aureus

28 July 2018

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NOD2 mediates inflammatory responses of primary murine glia to Streptococcus pneumoniae

28 July 2018

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CD14 signaling restrains chronic inflammation through induction of p38-MAPK/SOCS-dependent tolerance

28 July 2018

1 reference

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Nod2 is required for the regulation of commensal microbiota in the intestine

28 July 2018

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The caspase 1 inflammasome is not required for control of murine Lyme borreliosis

28 July 2018

1 reference

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Matrix metalloproteinase 9 plays a key role in lyme arthritis but not in dissemination of Borrelia burgdorferi

28 July 2018

1 reference

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A Crohn's disease-associated NOD2 mutation suppresses transcription of human IL10 by inhibiting activity of the nuclear ribonucleoprotein hnRNP-A1.

28 July 2018

1 reference

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The roles of TLRs, RLRs and NLRs in pathogen recognition

28 July 2018

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PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation

28 July 2018

1 reference

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A critical role for type I IFN in arthritis development following Borrelia burgdorferi infection of mice

28 July 2018

1 reference

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NOD2 plays an important role in the inflammatory responses of microglia and astrocytes to bacterial CNS pathogens

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Chronic Lyme disease: a review

28 July 2018

1 reference

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Lyme Arthritis: Pathogenesis, Clinical Presentation, and Management

28 July 2018

1 reference

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Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction

28 July 2018

1 reference

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A novel type I IFN-producing cell subset in murine lupus

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Identification and Biological Characterization of Mouse beta-defensin 14, the orthologue of human beta-defensin 3

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Phagocytosis of Borrelia burgdorferi, the Lyme disease spirochete, potentiates innate immune activation and induces apoptosis in human monocytes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

How NOD2 mutations predispose to Crohn's disease?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Phagocytosis of Borrelia burgdorferi and Treponema pallidum potentiates innate immune activation and induces gamma interferon production

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Nucleotide binding oligomerization domain 2 deficiency leads to dysregulated TLR2 signaling and induction of antigen-specific colitis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Reduced Paneth cell alpha-defensins in ileal Crohn's disease

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Expression and regulation of antimicrobial peptides in articular joints

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

NOD2 and Crohn's disease: loss or gain of function?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Myeloid differentiation antigen 88 deficiency impairs pathogen clearance but does not alter inflammation in Borrelia burgdorferi-infected mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Toll-like receptor 2 plays a pivotal role in host defense and inflammatory response to Borrelia burgdorferi

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Isolation and cultivation of Lyme disease spirochetes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Activation of human monocytes by live Borrelia burgdorferi generates TLR2-dependent and -independent responses which include induction of IFN-beta

28 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017414

MyD88 deficiency results in tissue-specific changes in cytokine induction and inflammation in interleukin-18-independent mice infected with Borrelia burgdorferi

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017414

Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017414

NLR proteins: integral members of innate immunity and mediators of inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017414

NOD2-deficient mice have impaired resistance to Mycobacterium tuberculosis infection through defective innate and adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017414

Chronic stimulation of Nod2 mediates tolerance to bacterial products

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017414

Recognition of Borrelia burgdorferi, the Lyme disease spirochete, by TLR7 and TLR9 induces a type I IFN response by human immune cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017414

The caspase-1 inflammasome: a pilot of innate immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017414

Role of aggrecanase 1 in Lyme arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017414

NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017414

Role of Nod2 in the development of Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017414

The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017414

Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0017414

Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Impaired dendritic cell function in Crohn's disease patients with NOD2 3020insC mutation

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3046161

Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi

29 October 2018

1 reference

12 December 2020

MyD88 plays a unique role in host defense but not arthritis development in Lyme disease

1 reference

12 December 2020

Contribution of NOD2 to lung inflammation during Staphylococcus aureus-induced pneumonia

1 reference

12 December 2020

Nucleotide-binding Oligomerization Domain-1 and Epidermal Growth Factor Receptor

1 reference

12 December 2020

Identification of a TLR-independent pathway for Borrelia burgdorferi-induced expression of matrix metalloproteinases and inflammatory mediators through binding to integrin alpha 3 beta 1

1 reference

12 December 2020

IL-10 deficiency promotes increased Borrelia burgdorferi clearance predominantly through enhanced innate immune responses

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0017414

Identifiers

DOI

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29 July 2017

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29 July 2017

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