A mathematical model of bone remodeling dynamics for normal bone cell populations and myeloma bone disease. (Q33843095)

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31 January 2020

title

A mathematical model of bone remodeling dynamics for normal bone cell populations and myeloma bone disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20406449%20AND%20SRC:MED&resulttype=core&format=json

31 January 2020

1 reference

1

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31 January 2020

Claire M Edwards

series ordinal

2

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31 January 2020

author name string

Glenn F Webb

series ordinal

3

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31 January 2020

John P Wikswo

series ordinal

4

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31 January 2020

publication date

20 April 2010

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31 January 2020

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31 January 2020

volume

5

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31 January 2020

page(s)

28

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Myeloma cells exhibit an increase in proteasome activity and an enhanced response to proteasome inhibition in the bone marrow microenvironment in vivo.

31 January 2020

cites work

1 reference

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Complex dynamics of osteoclast formation and death in long-term cultures

28 July 2018

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Mathematical model predicts a critical role for osteoclast autocrine regulation in the control of bone remodeling

28 July 2018

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Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro

28 July 2018

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Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model

28 July 2018

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Osteonal and hemi-osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone

28 July 2018

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Evidence for the secretion of an osteoclast stimulating factor in myeloma.

28 July 2018

1 reference

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Does myeloma secrete an osteoblast inhibiting factor?

28 July 2018

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Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma

28 July 2018

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Improving the damage accumulation in a biomechanical bone remodelling model

28 July 2018

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Mathematical modeling of spatio-temporal dynamics of a single bone multicellular unit.

29 October 2018

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The proteasome inhibitor, bortezomib suppresses primary myeloma and stimulates bone formation in myelomatous and nonmyelomatous bones in vivo

29 October 2018

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Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia

29 October 2018

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A unique three-dimensional model for evaluating the impact of therapy on multiple myeloma

29 October 2018

1 reference

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Model structure and control of bone remodeling: a theoretical study.

29 October 2018

1 reference

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Bortezomib inhibits osteoclast activity in patients with multiple myeloma

29 October 2018

1 reference

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Mathematical modeling and analysis of force induced bone growth

29 October 2018

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Stimulation of new bone formation by the proteasome inhibitor, bortezomib: implications for myeloma bone disease

29 October 2018

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Allosteric control model of bone remodelling containing periodical modes.

29 October 2018

1 reference

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Bone remodeling in health and disease: lessons from mathematical modeling.

29 October 2018

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A bone remodelling model coupling micro-damage growth and repair by 3D BMU-activity.

29 October 2018

1 reference

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Proteasome inhibitors abrogate osteoclast differentiation and osteoclast function

29 October 2018

1 reference

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Mathematical model of paracrine interactions between osteoclasts and osteoblasts predicts anabolic action of parathyroid hormone on bone.

29 October 2018

1 reference

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Sensitivity analysis of a novel mathematical model identifies factors determining bone resorption rates.

29 October 2018

1 reference

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Effects of pH on human bone marrow stromal cells in vitro: implications for tissue engineering of bone

29 October 2018

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Bone marrow stromal cells regulate caspase 3 activity in leukemic cells during chemotherapy

29 October 2018

1 reference

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The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

29 October 2018

1 reference

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Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-?B ligand concentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma

29 October 2018

1 reference

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Biochemical markers of bone formation in patients with plasma cell dyscrasias and benign osteoporosis

10 December 2018

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12 December 2020

Modeling the interactions between osteoblast and osteoclast activities in bone remodeling

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12 December 2020

Quantitative histology of myeloma-induced bone changes

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12 December 2020

Abnormal serum bone Gla protein levels in multiple myeloma. Crucial role of bone formation and prognostic implications

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12 December 2020

Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption

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12 December 2020

Long-term oral pamidronate treatment inhibits osteoclastic bone resorption and bone turnover without affecting osteoblastic function in multiple myeloma

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12 December 2020

Computer-simulated bone architecture in a simple bone-remodeling model based on a reaction-diffusion system

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12 December 2020

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12 December 2020

Identifiers

DOI

10.1186/1745-6150-5-28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20406449%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

31 January 2020

0 references

1 reference

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31 January 2020

PubMed publication ID

20406449

1 reference