Small molecule drug discovery for Dengue and West Nile viruses: applying experience from hepatitis C virus (Q33852451)

29 July 2017

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title

Small molecule drug discovery for Dengue and West Nile viruses: applying experience from hepatitis C virus (English)

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29 July 2017

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Tanya Parkinson

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PubMed ID

21426163

29 July 2017

David C Pryde

series ordinal

2

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29 July 2017

1 July 2010

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Future Medicinal Chemistry

29 July 2017

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29 July 2017

2

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29 July 2017

7

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29 July 2017

1181-1203

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The outbreak of West Nile virus infection in the New York City area in 1999

29 July 2017

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https://api.crossref.org/works/10.4155%2FFMC.10.195

West Nile virus: an overview of its spread in Europe and the Mediterranean basin in contrast to its spread in the Americas

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

West Nile virus: where are we now?

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.195

Immunopathology of flavivirus infections

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Neutralization and antibody-dependent enhancement of dengue viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Understanding the contribution of cellular immunity to dengue disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

West Nile virus: recent trends in diagnosis and vaccine development

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Progress towards a dengue vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Intravenous immunoglobulins in the treatment of dengue illness

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Present perspectives on flaviviral chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Structure of the dengue virus envelope protein after membrane fusion

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.195

Crystal Structure of the West Nile Virus Envelope Glycoprotein

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.195

Crystal Structure of Dengue Virus Type 1 Envelope Protein in the Postfusion Conformation and Its Implications for Membrane Fusion

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Quantifying the specific binding between West Nile virus envelope domain III protein and the cellular receptor alphaVbeta3 integrin

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Dendritic-cell-specific ICAM3-grabbing non-integrin is essential for the productive infection of human dendritic cells by mosquito-cell-derived dengue viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

DC-SIGN (CD209) mediates dengue virus infection of human dendritic cells

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.195

DC-SIGN enhances infection of cells with glycosylated West Nile virus in vitro and virus replication in human dendritic cells induces production of IFN-alpha and TNF-alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

The mannose receptor mediates dengue virus infection of macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Interaction of West Nile virus with alpha v beta 3 integrin mediates virus entry into cells

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.195

Rab 5 is required for the cellular entry of dengue and West Nile viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Hepatitis C Virus entry: the early steps in the viral replication cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Differential Enhancement of Dengue Virus Immune Complex Infectivity Mediated by Signaling-Competent and Signaling-Incompetent Human Fc RIA (CD64) or Fc RIIA (CD32)

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.195

Hepatitis C Virus Entry Requires a Critical Postinternalization Step and Delivery to Early Endosomes via Clathrin-Coated Vesicles

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.195

A small-molecule dengue virus entry inhibitor

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.195

Antiviral compounds discovered by virtual screening of small-molecule libraries against dengue virus E protein

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.195

Design, synthesis, and biological evaluation of antiviral agents targeting flavivirus envelope proteins

21 January 2018

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https://api.crossref.org/works/10.4155%2FFMC.10.195

Identification of novel target sites and an inhibitor of the dengue virus E protein

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

In vitro inhibition of dengue virus entry by p-sulfoxy-cinnamic acid and structurally related combinatorial chemistries

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Probing the interaction of dengue virus envelope protein with heparin: assessment of glycosaminoglycan-derived inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Antiviral effect of the heparan sulfate mimetic, PI-88, against dengue and encephalitic flaviviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

In vitro and in vivo antiviral properties of sulfated galactomannans against yellow fever virus (BeH111 strain) and dengue 1 virus (Hawaii strain).

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Interference in dengue virus adsorption and uncoating by carrageenans

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Dengue virus binding to human leukocyte cell lines: receptor usage differs between cell types and virus strains

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Serotype-specific entry of dengue virus into liver cells: identification of the 37-kilodalton/67-kilodalton high-affinity laminin receptor as a dengue virus serotype 1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Lethal antibody enhancement of dengue disease in mice is prevented by Fc modification

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Preclinical Evaluation of Two Neutralizing Human Monoclonal Antibodies against Hepatitis C Virus (HCV): a Potential Treatment To Prevent HCV Reinfection in Liver Transplant Patients

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Hepatitis C virus. The importance of viral heterogeneity.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

A second hepatitis C virus-encoded proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Identification and Biochemical Characterization of Small-Molecule Inhibitors of West Nile Virus Serine Protease by a High-Throughput Screen

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Identification and characterization of nonsubstrate based inhibitors of the essential dengue and West Nile virus proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

West Nile Virus NS2B/NS3 protease as an antiviral target

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Site-directed mutagenesis and kinetic studies of the West Nile Virus NS3 protease identify key enzyme-substrate interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Potent cationic inhibitors of West Nile virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Cleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Competitive inhibition of the dengue virus NS3 serine protease by synthetic peptides representing polyprotein cleavage sites

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Peptide inhibitors of West Nile NS3 protease: SAR study of tetrapeptide aldehyde inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Crystal structure of Dengue virus NS3 protease in complex with a Bowman-Birk inhibitor: implications for flaviviral polyprotein processing and drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Cleavage preference distinguishes the two-component NS2B–NS3 serine proteinases of Dengue and West Nile viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Structure-based discovery of dengue virus protease inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Structure–activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

NMR study of complexes between low molecular mass inhibitors and the West Nile virus NS2B-NS3 protease

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Discovery of a Non-Peptidic Inhibitor of West Nile Virus NS3 Protease by High-Throughput Docking

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Review article: investigational agents for chronic hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Structural evidence for regulation and specificity of flaviviral proteases and evolution of theFlaviviridaefold

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Peptidomimetic therapeutic agents targeting the protease enzyme of the human immunodeficiency virus and hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Insights into RNA unwinding and ATP hydrolysis by the flavivirus NS3 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

An analogue of AICAR with dual inhibitory activity against WNV and HCV NTPase/helicase: Synthesis and in vitro screening of 4-carbamoyl-5-(4,6-diamino-2,5-dihydro-1,3,5-triazin-2-yl)imidazole-1-β-d-ribofuranoside

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Characterization of imidazo[4,5-d]pyridazine nucleosides as modulators of unwinding reaction mediated by West Nile virus nucleoside triphosphatase/helicase: evidence for activity on the level of substrate and/or enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Halogenated benzimidazoles and benzotriazoles as inhibitors of the NTPase/helicase activities of hepatitis C and related viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Ring-expanded ("fat") nucleoside and nucleotide analogues exhibit potent in vitro activity against flaviviridae NTPases/helicases, including those of the West Nile virus, hepatitis C virus, and Japanese encephalitis virus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Synthesis and biological activity of 1H-benzotriazole and 1H-benzimidazole analogues--inhibitors of the NTpase/helicase of HCV and of some related Flaviviridae

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

An adenosine nucleoside inhibitor of dengue virus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

N-sulfonylanthranilic acid derivatives as allosteric inhibitors of dengue viral RNA-dependent RNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Targeting the non-structural proteins of hepatitis C virus: beyond hepatitis C virus protease and polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

RNA-dependent RNA polymerases from Flaviviridae

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

West Nile Virus Methyltransferase Catalyzes Two Methylations of the Viral RNA Cap through a Substrate-Repositioning Mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Analysis of Flavivirus NS5 Methyltransferase Cap Binding

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Structure and Function of Flavivirus NS5 Methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2'O)-methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Flaviviral methyltransferase/RNA interaction: structural basis for enzyme inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Biochemistry and clinical applications of ribavirin

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

The predominant mechanism by which ribavirin exerts its antiviral activity in vitro against flaviviruses and paramyxoviruses is mediated by inhibition of IMP dehydrogenase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Effect of interferon-alpha and interferon-inducers on West Nile virus in mouse and hamster animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Clinical characteristics of the West Nile fever outbreak, Israel, 2000

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Treatment of intracranial dengue virus infections in mice with a lipophilic derivative of ribavirin

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Viramidine, a prodrug of ribavirin, shows better liver-targeting properties and safety profiles than ribavirin in animals.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Interferon, ribavirin, 6-azauridine and glycyrrhizin: antiviral compounds active against pathogenic flaviviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Broad-spectrum inhibitor of viruses in the Flaviviridae family

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Inhibition of dengue virus replication by mycophenolic acid and ribavirin

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Pharmacokinetics and bioavailability of mycophenolate mofetil in healthy subjects after single-dose oral and intravenous administration

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

A novel model for the study of the therapy of flavivirus infections using the Modoc virus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Mycophenolic acid inhibits dengue virus infection by preventing replication of viral RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Identification of active antiviral compounds against a New York isolate of West Nile virus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Synthesis and evaluation of N-substituted acridones as antiviral agents against haemorrhagic fever viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

A heterocyclic molecule with significant activity against dengue virus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Ribavirin as therapy for chronic hepatitis C. A randomized, double-blind, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Randomised, double-blind, placebo-controlled trial of interferon alpha-2b with and without ribavirin for chronic hepatitis C. The Swedish Study Group

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Mycophenolate mofetil in combination with recombinant interferon alfa-2a in interferon-nonresponder patients with chronic hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Peginterferon alpha-2a combination therapies in chronic hepatitis C patients who relapsed after or had a viral breakthrough on therapy with standard interferon alpha-2b plus ribavirin: a pilot study of efficacy and safety

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Safety and efficacy of viramidine versus ribavirin in ViSER2: randomized, double-blind study in therapy-naive hepatitis C patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

The effect of ribavirin and IMPDH inhibitors on hepatitis C virus subgenomic replicon RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Prophylactic ribavirin treatment of dengue type 1 infection in rhesus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Alpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Antiviral effects of an iminosugar derivative on flavivirus infections

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Novel Imino Sugar Derivatives Demonstrate Potent Antiviral Activity against Flaviviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Castanospermine, a potent inhibitor of dengue virus infection in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Novel five-membered iminocyclitol derivatives as selective and potent glycosidase inhibitors: new structures for antivirals and osteoarthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

c-Src protein kinase inhibitors block assembly and maturation of dengue virus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Minocycline inhibits West Nile virus replication and apoptosis in human neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Involvement of the JNK-like protein of the Aedes albopictus mosquito cell line, C6/36, in phagocytosis, endocytosis and infection of West Nile virus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Cyclophilin inhibitors in hepatitis C viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

A genome-wide genetic screen for host factors required for hepatitis C virus propagation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Identification of host genes involved in hepatitis C virus replication by small interfering RNA technology

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Cellular cofactors affecting hepatitis C virus infection and replication

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

A Functional Genomic Screen Identifies Cellular Cofactors of Hepatitis C Virus Replication

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Identification of a lipid kinase as a host factor involved in hepatitis C virus RNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Triaryl pyrazoline compound inhibits flavivirus RNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Identification of Novel Small-Molecule Inhibitors of West Nile Virus Infection

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Sultam Thiourea Inhibition of West Nile Virus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Antiviral activity of geneticin against dengue virus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Identification and characterization of inhibitors of West Nile virus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Adaptation of West Nile virus replicons to cells in culture and use of replicon-bearing cells to probe antiviral action.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Discovery of small molecule inhibitors of West Nile virus using a high-throughput sub-genomic replicon screen

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

The influence of drug-like concepts on decision-making in medicinal chemistry

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

HCV796: A selective nonstructural protein 5B polymerase inhibitor with potent anti-hepatitis C virus activity in vitro, in mice with chimeric human livers, and in humans infected with hepatitis C virus

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Preclinical Characterization of PF-00868554, a Potent Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC.10.195

21 January 2018

Identifiers

DOI

10.4155/FMC.10.195

1 reference

29 July 2017

1 reference

PubMed ID

21426163