A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators (Q33855651)

29 July 2017

A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators (English)

1 reference

29 July 2017

8

Loren D Walensky

1 reference

29 July 2017

Benjamin Szlyk

1

1 reference

29 July 2017

Craig R Braun

2

1 reference

29 July 2017

Sanda Ljubicic

3

1 reference

29 July 2017

Elaura Patton

4

1 reference

29 July 2017

Gregory H Bird

5

1 reference

29 July 2017

Mayowa A Osundiji

6

1 reference

29 July 2017

Franz M Matschinsky

7

1 reference

29 July 2017

Nika N Danial

9

1 reference

29 July 2017

8 December 2013

1 reference

Nature Structural & Molecular Biology

29 July 2017

1 reference

29 July 2017

21

1 reference

29 July 2017

1

1 reference

29 July 2017

36-42

1 reference

https://scigraph.springernature.com/pub.10.1038/nsmb.2717

29 July 2017

0 references

cites work

Direct activation of full-length proapoptotic BAK

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Investigational anti-hyperglycemic agents: the future of type 2 diabetes therapy?

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Glucose metabolism: key endogenous regulator of β-cell replication and survival.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Diabetes mellitus and the β cell: the last ten years

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Mechanisms for insulin resistance: common threads and missing links

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Homotropic allosteric regulation in monomeric mammalian glucokinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

The active conformation of human glucokinase is not altered by allosteric activators

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Susceptibility of glucokinase-MODY mutants to inactivation by oxidative stress in pancreatic β-cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Effects of MK-0941, a novel glucokinase activator, on glycemic control in insulin-treated patients with type 2 diabetes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Global fit analysis of glucose binding curves reveals a minimal model for kinetic cooperativity in human glucokinase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Insulin signaling regulates mitochondrial function in pancreatic beta-cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Update on mutations in glucokinase (GCK), which cause maturity-onset diabetes of the young, permanent neonatal diabetes, and hyperinsulinemic hypoglycemia

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Investigation of functionally liver selective glucokinase activators for the treatment of type 2 diabetes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

BAD: undertaker by night, candyman by day.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Binding kinetics of glucose and allosteric activators to human glucokinase reveal multiple conformational states.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Pyridones as glucokinase activators: identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Assessing the potential of glucokinase activators in diabetes therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Glucokinase activators for the potential treatment of type 2 diabetes

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

BAX activation is initiated at a novel interaction site

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Catalytic activation of human glucokinase by substrate binding: residue contacts involved in the binding of D-glucose to the super-open form and conformational transitions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Increased albumin concentration reduces apoptosis and improves functionality of human islets

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Methods of human islet culture for transplantation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Mutants of glucokinase cause hypoglycaemia- and hyperglycaemia syndromes and their analysis illuminates fundamental quantitative concepts of glucose homeostasis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Glucokinase mutations associated with non-insulin-dependent (type 2) diabetes mellitus have decreased enzymatic activity: implications for structure/function relationships

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Demonstration of a slow conformational change in liver glucokinase by fluorescence spectroscopy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4084830

Dipeptidyl peptidase-4 inhibitors and preservation of pancreatic islet-cell function: a critical appraisal of the evidence

28 July 2018

1 reference

Allosteric activators of glucokinase: potential role in diabetes therapy

21 January 2018

1 reference

Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase

21 January 2018

1 reference

Direct evidence of conformational heterogeneity in human pancreatic glucokinase from high-resolution nuclear magnetic resonance

21 January 2018

1 reference

Insights into Mechanism of Glucokinase Activation

21 January 2018

1 reference

Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.

21 January 2018

1 reference

An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory protein and regulates glucose metabolism

21 January 2018

1 reference

Piragliatin (RO4389620), a novel glucokinase activator, lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus: a mechanistic study

21 January 2018

1 reference

A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers.

21 January 2018

1 reference

Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators

21 January 2018

1 reference

Glucokinase-activating ureas

21 January 2018

1 reference

A novel glucokinase activator modulates pancreatic islet and hepatocyte function

21 January 2018

1 reference

Glucose modulation of glucokinase activation by small molecules

21 January 2018

1 reference

Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome.

21 January 2018

1 reference

Mutational analysis of allosteric activation and inhibition of glucokinase

21 January 2018

1 reference

Structural instability of mutant beta-cell glucokinase: implications for the molecular pathogenesis of maturity-onset diabetes of the young (type-2).

21 January 2018

1 reference

Variable effects of maturity-onset-diabetes-of-youth (MODY)-associated glucokinase mutations on substrate interactions and stability of the enzyme

21 January 2018

1 reference

Opposite clinical phenotypes of glucokinase disease: Description of a novel activating mutation and contiguous inactivating mutations in human glucokinase (GCK) gene.

21 January 2018

1 reference

Large Islets, Beta-Cell Proliferation, and a Glucokinase Mutation

21 January 2018

1 reference

Long-term overexpression of glucokinase in the liver of transgenic mice leads to insulin resistance.

21 January 2018

1 reference

Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.

21 January 2018

1 reference

Hepatic glucokinase expression is associated with lipogenesis and fatty liver in humans.

21 January 2018

1 reference

Dose-ranging study with the glucokinase activator AZD1656 as monotherapy in Japanese patients with type 2 diabetes mellitus

21 January 2018

1 reference

Dose-ranging study with the glucokinase activator AZD1656 in patients with type 2 diabetes mellitus on metformin

21 January 2018

1 reference

An approach to correlate tandem mass spectral data of peptides with amino acid sequences in a protein database

21 January 2018

1 reference

Tolerability, pharmacokinetics, and pharmacodynamics of the glucokinase activator AZD1656, after single ascending doses in healthy subjects during euglycemic clamp

21 January 2018

1 reference

Nine novel mutations in maturity-onset diabetes of the young (MODY) candidate genes in 22 Spanish families

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB.2717

1 reference

29 July 2017

1 reference

29 July 2017

1 reference