A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. (Q30466831)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22622039%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

title

A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers (English)

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2 February 2020

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Evripidis Gavathiotis

4

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2 February 2020

Kenneth Pitter

9

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2 February 2020

Andrew L. Kung

10

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Loren D Walensky

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2 February 2020

author name string

James L LaBelle

1

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2 February 2020

Samuel G Katz

2

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2 February 2020

Gregory H Bird

3

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2 February 2020

Michelle L Stewart

5

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2 February 2020

Chelsea Lawrence

6

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2 February 2020

Jill K Fisher

7

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2 February 2020

Marina Godes

8

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2 February 2020

language of work or name

English

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publication date

24 May 2012

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Journal of Clinical Investigation

2 February 2020

published in

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volume

122

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2 February 2020

issue

6

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2 February 2020

page(s)

2018-2031

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Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics.

2 February 2020

cites work

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The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

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Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes

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The role of BH3-only protein Bim extends beyond inhibiting Bcl-2-like prosurvival proteins

14 July 2018

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Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins

14 July 2018

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BAX activation is initiated at a novel interaction site

14 July 2018

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MicroRNA-17-92 down-regulates expression of distinct targets in different B-cell lymphoma subtypes

14 July 2018

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A novel Bim-BH3-derived Bcl-XL inhibitor: biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity

14 July 2018

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Completing the family portrait of the anti-apoptotic Bcl-2 proteins: crystal structure of human Bfl-1 in complex with Bim

14 July 2018

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Bcl-XL inhibits membrane permeabilization by competing with Bax.

14 July 2018

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ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

14 July 2018

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Targeting Bcl-2 family members with the BH3 mimetic AT-101 markedly enhances the therapeutic effects of chemotherapeutic agents in in vitro and in vivo models of B-cell lymphoma

14 July 2018

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Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion

14 July 2018

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Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

14 July 2018

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BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents

14 July 2018

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

14 July 2018

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

14 July 2018

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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

14 July 2018

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A stapled BID BH3 helix directly binds and activates BAX

14 July 2018

1 reference

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Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies

14 July 2018

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Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas

14 July 2018

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

14 July 2018

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14 July 2018

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14 July 2018

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

14 July 2018

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

14 July 2018

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Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM.

14 July 2018

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Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

14 July 2018

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Alkylating DNA damage stimulates a regulated form of necrotic cell death

14 July 2018

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Bim is a suppressor of Myc-induced mouse B cell leukemia

14 July 2018

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Cell death: critical control points

14 July 2018

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The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

14 July 2018

1 reference

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

14 July 2018

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

14 July 2018

1 reference

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Hematopoietic malignancies demonstrate loss-of-function mutations of BAX

14 July 2018

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

14 July 2018

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Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation

14 July 2018

1 reference

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BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

14 July 2018

1 reference

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Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains

26 November 2018

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Antiapoptotic BCL-2 is required for maintenance of a model leukemia

26 November 2018

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12 December 2020

Nonionic detergents induce dimerization among members of the Bcl-2 family

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12 December 2020

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

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12 December 2020

TAT-Bim induces extensive apoptosis in cancer cells

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Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains

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12 December 2020

Identifiers

DOI

10.1172/JCI46231

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22622039%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22622039%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

PubMed publication ID

22622039

1 reference