The two sides of enzyme-substrate specificity: lessons from the aspartic proteinases (Q33857494)

29 July 2017

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title

The two sides of enzyme-substrate specificity: lessons from the aspartic proteinases (English)

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29 July 2017

B M Dunn

1

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PubMed ID

10708860

29 July 2017

S Hung

series ordinal

2

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PubMed ID

10708860

29 July 2017

language of work or name

English

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publication date

1 March 2000

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29 July 2017

10

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Biochimica et Biophysica Acta

inferred from page(s)

published in

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29 July 2017

1477

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29 July 2017

1-2

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29 July 2017

231-240

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Evolution of structure and function of proteases

29 July 2017

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https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

CRYSTALLINE PEPSIN : I. ISOLATION AND TESTS OF PURITY

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https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

Amino-acid sequence of porcine pepsin

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

X-ray analyses of aspartic proteinases. The three-dimensional structure at 2.1 A resolution of endothiapepsin

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

Structure and refinement at 1.8 A resolution of the aspartic proteinase from Rhizopus chinensis

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

Penicillopepsin from Penicillium janthinellum crystal structure at 2.8 Å and sequence homology with porcine pepsin

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

Pyridyl esters of peptides as synthetic substrates of pepsin

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

Effect of secondary substrate binding in penicillopepsin: contributions of subsites S3 and S2' to kcat

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

Specificity and Mechanism of Pepsin Action on Synthetic Substrates

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

Subsite Specificity of Porcine Pepsin

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

A new chromophoric substrate for penicillopepsin and other fungal aspartic proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

The synthesis, purification, and evaluation of a chromophoric substrate for pepsin and other aspartyl proteases: design of a substrate based on subsite preferences

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

A systematic series of synthetic chromophoric substrates for aspartic proteinases

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

Secondary enzyme-substrate interactions: kinetic evidence for ionic interactions between substrate side chains and the pepsin active site

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

Exploration of subsite binding specificity of human cathepsin D through kinetics and rule-based molecular modeling

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

Active site specificity of plasmepsin II

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

Prime region subsite specificity characterization of human cathepsin D: the dominant role of position 128.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

Engineering the substrate specificity of rhizopuspepsin: the role of Asp 77 of fungal aspartic proteinases in facilitating the cleavage of oligopeptide substrates with lysine in P1

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

Redesign of the substrate specificity of human cathepsin D: the dominant role of position 287 in the S2 subsite.

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

Designing substrate specificity by protein engineering of electrostatic interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

Electrostatic reversal of serine proteinase substrate specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

Cleavage efficiency of the novel aspartic protease yapsin 1 (Yap3p) enhanced for substrates with arginine residues flanking the P1 site: correlation with electronegative active-site pockets predicted by molecular modeling

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

An unequivocal example of cysteine proteinase activity affected by multiple electrostatic interactions

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

A classical enzyme active center motif lacks catalytic competence until modulated electrostatically

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

The enhancing of a cysteine proteinase activity at acidic pH by protein engineering, the role of glutamic 50 in the enzyme mechanism of caricain

1 reference

https://api.crossref.org/works/10.1016%2FS0167-4838%2899%2900275-7

7 January 2021

10.1016/S0167-4838(99)00275-7

Identifiers

DOI

1 reference

29 July 2017

1 reference

PubMed ID

10708860