Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha-induced metabolic reprograming (Q33869316)

29 July 2017

title

Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha-induced metabolic reprograming (English)

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29 July 2017

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F Zhao

1

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29 July 2017

A Mancuso

2

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29 July 2017

T V Bui

3

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29 July 2017

X Tong

4

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29 July 2017

J J Gruber

5

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29 July 2017

C R Swider

6

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29 July 2017

P V Sanchez

7

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29 July 2017

J J Lum

8

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29 July 2017

N Sayed

9

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29 July 2017

J V Melo

10

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29 July 2017

A E Perl

11

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29 July 2017

M Carroll

12

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29 July 2017

S W Tuttle

13

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29 July 2017

C B Thompson

14

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29 July 2017

language of work or name

English

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publication date

15 March 2010

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29 July 2017

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29 July 2017

volume

29

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29 July 2017

issue

20

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29 July 2017

page(s)

2962-2972

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Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

29 July 2017

cites work

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5 July 2018

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Applying the discovery of the Philadelphia chromosome

5 July 2018

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Detection of reactive oxygen species via endogenous oxidative pentose phosphate cycle activity in response to oxygen concentration: implications for the mechanism of HIF-1alpha stabilization under moderate hypoxia

5 July 2018

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The transcription factor HIF-1alpha plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874611

Role of BCR/ABL gene-expression levels in determining the phenotype and imatinib sensitivity of transformed human hematopoietic cells

5 July 2018

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Enhanced growth of myelodysplastic colonies in hypoxic conditions

5 July 2018

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Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism

5 July 2018

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Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro

5 July 2018

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HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

5 July 2018

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HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

5 July 2018

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Targeted CML therapy: controlling drug resistance, seeking cure

5 July 2018

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ATP citrate lyase inhibition can suppress tumor cell growth

5 July 2018

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Bcr-Abl expression levels determine the rate of development of resistance to imatinib mesylate in chronic myeloid leukemia

5 July 2018

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Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation.

5 July 2018

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A non-ATP-competitive inhibitor of BCR-ABL overrides imatinib resistance

5 July 2018

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Imatinib inhibits the functional capacity of cultured human monocytes.

5 July 2018

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The development of imatinib as a therapeutic agent for chronic myeloid leukemia

5 July 2018

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Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells

5 July 2018

1 reference

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Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

5 July 2018

1 reference

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BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1alpha, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin.

5 July 2018

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Elevated Bcr-Abl expression levels are sufficient for a haematopoietic cell line to acquire a drug-resistant phenotype

5 July 2018

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Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874611

Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance.

5 July 2018

1 reference

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Expression of hypoxia-inducible genes in tumor cells

5 July 2018

1 reference

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CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874611

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

5 July 2018

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Sensitivity to chemical oxidants and radiation in CHO cell lines deficient in oxidative pentose cycle activity

5 July 2018

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Hypoxia promotes relaxation of bovine coronary arteries through lowering cytosolic NADPH.

5 July 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.67

Differential protein expression in brain capillary endothelial cells induced by hypoxia and posthypoxic reoxygenation

21 January 2018

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The presence of a BCR-ABL mutant allele in CML does not always explain clinical resistance to imatinib

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.67

Abnormalities in glucose uptake and metabolism in imatinib-resistant human BCR-ABL-positive cells.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.67

A stable reagent mixture for the whole blood transketolase assay

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.67

Hypoxia suppresses BCR/Abl and selects imatinib-insensitive progenitors within clonal CML populations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.67

The Labeling of Pentose Phosphate from Glucose-14C and Estimation of the Rates of Transaldolase, Transketolase, the Contribution of the Pentose Cycle, and Ribose Phosphate Synthesis*

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.67

Contribution of de-novo and salvage synthesis to the uracil nucleotide pool in mouse tissues and tumors in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.67

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.67

1 reference

Dimensions Publication ID

29 July 2017

0 references

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29 July 2017

1 reference