Signal transduction by protease-activated receptors (Q33870369)

29 July 2017

1 reference

title

Signal transduction by protease-activated receptors (English)

1 reference

thrombin-activated receptor activity

29 July 2017

main subject

1 reference

Gene Ontology release 2020-05-02

Unice J K Soh

1

1 reference

29 July 2017

Michael R Dores

series ordinal

2

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29 July 2017

Buxin Chen

series ordinal

3

1 reference

29 July 2017

JoAnn Trejo

series ordinal

4

1 reference

29 July 2017

language of work or name

English

0 references

publication date

1 May 2010

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British Journal of Pharmacology

29 July 2017

published in

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29 July 2017

volume

160

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29 July 2017

issue

2

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29 July 2017

page(s)

191-203

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Phosphorylation of protease-activated receptor-2 differentially regulates desensitization and internalization

29 July 2017

cites work

1 reference

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Zyxin is involved in thrombin signaling via interaction with PAR-1 receptor

5 July 2018

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Thrombin promotes release of ATP from lung epithelial cells through coordinated activation of rho- and Ca2+-dependent signaling pathways

5 July 2018

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Proteases display biased agonism at protease-activated receptors: location matters!

5 July 2018

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5 July 2018

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Caveolae are required for protease-selective signaling by protease-activated receptor-1.

5 July 2018

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Discovery of new GPCR biology: one receptor structure at a time

5 July 2018

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Matrix metalloproteinase-1 and thrombin differentially activate gene expression in endothelial cells via PAR-1 and promote angiogenesis

5 July 2018

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5 July 2018

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5 July 2018

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Analysis of proteinase-activated receptor 2 and TLR4 signal transduction: a novel paradigm for receptor cooperativity

5 July 2018

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Location, location, location...site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling

5 July 2018

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Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1.

5 July 2018

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5 July 2018

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Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity

5 July 2018

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Postendocytotic traffic of the galanin R1 receptor: a lysosomal signal motif on the cytoplasmic terminus

5 July 2018

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Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation

5 July 2018

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Regulation of GPCRs by endocytic membrane trafficking and its potential implications

5 July 2018

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Activated protein C-cleaved protease activated receptor-1 is retained on the endothelial cell surface even in the presence of thrombin

5 July 2018

1 reference

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Heterotrimeric G protein activation by G-protein-coupled receptors

5 July 2018

1 reference

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Dual regulation of endothelial junctional permeability

5 July 2018

1 reference

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G protein-coupled receptor sorting to endosomes and lysosomes

5 July 2018

1 reference

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'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage

5 July 2018

1 reference

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How do receptors activate G proteins?

5 July 2018

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The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells

5 July 2018

1 reference

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p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking

5 July 2018

1 reference

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Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) mediates post-endocytic trafficking of protease-activated receptor 2 and calcitonin receptor-like receptor

5 July 2018

1 reference

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Ubiquitination differentially regulates clathrin-dependent internalization of protease-activated receptor-1

5 July 2018

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Biogenesis and function of multivesicular bodies

5 July 2018

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5 July 2018

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Protease-activated receptor-3 (PAR3) regulates PAR1 signaling by receptor dimerization

5 July 2018

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Clathrin-dependent mechanisms of G protein-coupled receptor endocytosis

5 July 2018

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Phosphorylation-independent attenuation of GPCR signalling

5 July 2018

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Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells

5 July 2018

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The cytoprotective protein C pathway

5 July 2018

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Regulation of receptor trafficking by GRKs and arrestins

5 July 2018

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Trafficking of G protein-coupled receptors

5 July 2018

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Functional Selectivity and Classical Concepts of Quantitative Pharmacology

5 July 2018

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The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain

5 July 2018

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Clathrin adaptor AP2 regulates thrombin receptor constitutive internalization and endothelial cell resensitization

5 July 2018

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5 July 2018

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The structural basis of arrestin-mediated regulation of G-protein-coupled receptors

5 July 2018

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Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1

5 July 2018

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An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins

5 July 2018

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Protease-activated receptors in hemostasis, thrombosis and vascular biology

5 July 2018

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Transduction of receptor signals by beta-arrestins

5 July 2018

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c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2

5 July 2018

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Endothelial barrier protection by activated protein C through PAR1-dependent sphingosine 1-phosphate receptor-1 crossactivation

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Protease-activated receptor 2 in colon cancer: trypsin-induced MAPK phosphorylation and cell proliferation are mediated by epidermal growth factor receptor transactivation

5 July 2018

1 reference

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Signals for sorting of transmembrane proteins to endosomes and lysosomes

5 July 2018

1 reference

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Rab5a and rab11a mediate agonist-induced trafficking of protease-activated receptor 2.

5 July 2018

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PARticipation in inflammation

5 July 2018

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Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1

5 July 2018

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Activation of endothelial cell protease activated receptor 1 by the protein C pathway

5 July 2018

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Aspartic acid 564 in the third cytoplasmic loop of the luteinizing hormone/choriogonadotropin receptor is crucial for phosphorylation-independent interaction with arrestin2.

5 July 2018

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Thrombin receptor signaling to cytoskeleton requires Hsp90.

5 July 2018

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Interleukin-6 production by endothelial cells via stimulation of protease-activated receptors is amplified by endotoxin and tumor necrosis factor-alpha

5 July 2018

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Creatine kinase, an ATP-generating enzyme, is required for thrombin receptor signaling to the cytoskeleton

5 July 2018

1 reference

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Protease-activated receptor-1 down-regulation: a mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits

5 July 2018

1 reference

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G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells

5 July 2018

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Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin

5 July 2018

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Thrombin responses in human endothelial cells. Contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1.

5 July 2018

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PAR3 is a cofactor for PAR4 activation by thrombin

5 July 2018

1 reference

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beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2

5 July 2018

1 reference

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EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

5 July 2018

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Trafficking of proteinase-activated receptor-2 and beta-arrestin-1 tagged with green fluorescent protein. beta-Arrestin-dependent endocytosis of a proteinase receptor

5 July 2018

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The 2.8 A crystal structure of visual arrestin: a model for arrestin's regulation

5 July 2018

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The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis

5 July 2018

1 reference

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The cytoplasmic tails of protease-activated receptor-1 and substance P receptor specify sorting to lysosomes versus recycling

5 July 2018

1 reference

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Termination of signaling by protease-activated receptor-1 is linked to lysosomal sorting

5 July 2018

1 reference

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Thrombin receptors on human platelets. Initial localization and subsequent redistribution during platelet activation

5 July 2018

1 reference

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Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor

5 July 2018

1 reference

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Ubiquitination of the yeast a-factor receptor

5 July 2018

1 reference

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Mechanisms of desensitization and resensitization of proteinase-activated receptor-2.

5 July 2018

1 reference

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Agonist recognition by proteinase-activated receptor 2 and thrombin receptor. Importance of extracellular loop interactions for receptor function

5 July 2018

1 reference

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Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

5 July 2018

1 reference

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Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis

5 July 2018

1 reference

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Differential role of the carboxyl-terminal tyrosine in down-regulation and sequestration of the m2 muscarinic acetylcholine receptor.

5 July 2018

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Specificity of the thrombin receptor for agonist peptide is defined by its extracellular surface

5 July 2018

1 reference

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Intracellular targeting and trafficking of thrombin receptors. A novel mechanism for resensitization of a G protein-coupled receptor

5 July 2018

1 reference

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Kinetics of thrombin receptor cleavage on intact cells. Relation to signaling.

5 July 2018

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beta-Arrestin: a protein that regulates beta-adrenergic receptor function

5 July 2018

1 reference

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Domains specifying thrombin–receptor interaction

5 July 2018

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Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874842

Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874842

Tethered ligand agonist peptides. Structural requirements for thrombin receptor activation reveal mechanism of proteolytic unmasking of agonist function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874842

Proteinase-activated receptor-2: key role of amino-terminal dipeptide residues of the tethered ligand for receptor activation

5 July 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00705.X

Guide to Receptors and Channels (GRAC), 3rd edition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00705.X

Termination of protease-activated receptor-1 signaling by beta-arrestins is independent of receptor phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00705.X

Endosomal sorting and signalling: an emerging role for sorting nexins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00705.X

Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00705.X

Regulated shedding of PAR1 N-terminal exodomain from endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00705.X

Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-activated receptor-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00705.X

Activated protein C variants with normal cytoprotective but reduced anticoagulant activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00705.X

Arrestin-like proteins mediate ubiquitination and endocytosis of the yeast metal transporter Smf1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00705.X

A tyrosine-based sorting signal regulates intracellular trafficking of protease-activated receptor-1: multiple regulatory mechanisms for agonist-induced G protein-coupled receptor internalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00705.X

A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00705.X

Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874842

Extracellular mutations of protease-activated receptor-1 result in differential activation by thrombin and thrombin receptor agonist peptide.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874842

Inhibition of thrombin receptor signaling by a G-protein coupled receptor kinase. Functional specificity among G-protein coupled receptor kinases

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874842

Thrombin receptor activation. Confirmation of the intramolecular tethered liganding hypothesis and discovery of an alternative intermolecular liganding mode.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2874842

Plasmin Desensitization of the PAR1 Thrombin Receptor: Kinetics, Sites of Truncation, and Implications for Thrombolytic Therapy†

29 October 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00705.X

The role of receptor kinases and arrestins in G protein-coupled receptor regulation

21 January 2018

1 reference

12 December 2020

Parstatin, the cleaved peptide on proteinase-activated receptor 1 activation, is a potent inhibitor of angiogenesis

1 reference

12 December 2020

GPIIb-IIIa antagonist-induced reduction in platelet surface factor V/Va binding and phosphatidylserine expression in whole blood

1 reference

12 December 2020

The cleaved peptide of PAR1 results in a redistribution of the platelet surface GPIb-IX-V complex to the surface-connected canalicular system

1 reference

12 December 2020

beta -Arrestins regulate protease-activated receptor-1 desensitization but not internalization or Down-regulation

1 reference

12 December 2020

10.1111/J.1476-5381.2010.00705.X

Identifiers

DOI

1 reference

29 July 2017

1 reference

29 July 2017

1 reference