Regulation of gamma-glutamylcysteine synthetase subunit gene expression: insights into transcriptional control of antioxidant defenses (Q33878163)

29 July 2017

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title

Regulation of gamma-glutamylcysteine synthetase subunit gene expression: insights into transcriptional control of antioxidant defenses (English)

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29 July 2017

Wild AC

1

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PubMed ID

10741850

29 July 2017

Mulcahy RT

series ordinal

2

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29 July 2017

1 April 2000

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29 July 2017

Free Radical Research

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29 July 2017

32

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29 July 2017

4

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29 July 2017

281-301

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https://api.crossref.org/works/10.1080%2F10715760000300291

29 July 2017

1 reference

Expression and purification of human gamma-glutamylcysteine synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Expression and characterization of human glutamate-cysteine ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Biologic and pharmacologic regulation of mammalian glutathione synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Regulation of hepatic glutathione synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Hormone-mediated down-regulation of hepatic glutathione synthesis in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Regulation of gamma-glutamylcysteine synthetase by protein phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Hydrogen peroxide increases the activity of gamma-glutamylcysteine synthetase in cultured Chinese hamster V79 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Assignment of the human gene (GLCLR) that encodes the regulatory subunit of gamma-glutamylcysteine synthetase to chromosome 1p21

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Genetic mapping of GLCLC, the human gene encoding the catalytic subunit of gamma-glutamyl-cysteine synthetase, to chromosome band 6p12 and characterization of a polymorphic trinucleotide repeat within its 5' untranslated region

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Structure and refinement of the physical mapping of the gamma- glutamylcysteine ligase regulatory subunit (GLCLR) gene to chromosome 1p22.1 within the critically deleted region of human malignant mesothelioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Cloning and nucleotide sequence of a full-length cDNA for human liver gamma-glutamylcysteine synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Cloning and sequencing of the cDNA for the light subunit of human liver gamma-glutamylcysteine synthetase and relative mRNA levels for heavy and light subunits in human normal tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Identification of a putative antioxidant response element in the 5'-flanking region of the human gamma-glutamylcysteine synthetase heavy subunit gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Constitutive and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Regulation of human gamma-glutamylcysteine synthetase: co-ordinate induction of the catalytic and regulatory subunits in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

An electrophile responsive element (EpRE) regulates beta-naphthoflavone induction of the human gamma-glutamylcysteine synthetase regulatory subunit gene. Constitutive expression is mediated by an adjacent AP-1 site

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

GSH1, which encodes gamma-glutamylcysteine synthetase, is a target gene for yAP-1 transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Transcriptional activation by the SV40 AP-1 recognition element in yeast is mediated by a factor similar to AP-1 that is distinct from GCN4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Expression of the SV40 promoter in fission yeast: identification and characterization of an AP-1-like factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Identification and characterization of a Saccharomyces cerevisiae gene (PAR1) conferring resistance to iron chelators

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Stress-induced transcriptional activation mediated by YAP1 and YAP2 genes that encode the Jun family of transcriptional activators in Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Regulation of yAP-1 nuclear localization in response to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Overlapping antioxidant response element and PMA response element sequences mediate basal and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase catalytic subunit gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Inducible expression of the gamma-glutamylcysteine synthetase light subunit by t-butylhydroquinone in HepG2 cells is not dependent on an antioxidant-responsive element

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

A dominant negative to activation protein-1 (AP1) that abolishes DNA binding and inhibits oncogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Embryonic lethality and liver degeneration in mice lacking the metal-responsive transcriptional activator MTF-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Induction of antioxidants by adriamycin in mouse heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Posttranscriptional regulation of MRP/GS-X pump and gamma-glutamylcysteine synthetase expression by 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea and by cycloheximide in human glioma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Apocynin increases glutathione synthesis and activates AP-1 in alveolar epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Differential regulation of gamma-glutamylcysteine synthetase heavy and light subunit gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Increased transcription of the regulatory subunit of gamma-glutamylcysteine synthetase in rat lung epithelial L2 cells exposed to oxidative stress or glutathione depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Modulation of gamma-glutamylcysteine synthetase large subunit mRNA expression by butylated hydroxyanisole.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Up-regulation of glutamate-cysteine ligase gene expression by butylated hydroxytoluene is mediated by transcription factor AP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

The effects of diquat and ciprofibrate on mRNA expression and catalytic activities of hepatic xenobiotic metabolizing and antioxidant enzymes in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Alteration of transcriptional and post-transcriptional expression of gamma-glutamylcysteine synthetase by diethyl maleate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Glial cells protect neurons against oxidative stress via transcriptional up-regulation of the glutathione synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Protective role of glutathione synthesis on radiation-induced DNA damage in rabbit brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase by ionizing radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Localization of glutathione and induction of glutathione synthesis-related proteins in mouse brain by low doses of gamma-rays.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Nuclear factor kappa B dependent induction of gamma glutamylcysteine synthetase by ionizing radiation in T98G human glioblastoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Enhancement of gamma-glutamylcysteine synthetase mRNA in rat kidney by methyl mercury

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Localization of gamma-glutamylcysteine synthetase mRNA expression in mouse brain following methylmercury treatment using reverse transcription in situ PCR amplification

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Induction of the cell cycle regulatory gene p21 (Waf1, Cip1) following methylmercury exposure in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Modulation of gene expression in subjects at risk for colorectal cancer by the chemopreventive dithiolethione oltipraz

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Differential enhancement of gamma-glutamyl transpeptidase and gamma-glutamylcysteine synthetase by tert-butylhydroquinone in rat lung epithelial L2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Molecular mechanism of the regulation of glutathione synthesis by tumor necrosis factor-alpha and dexamethasone in human alveolar epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Long exposure to high glucose concentration impairs the responsive expression of gamma-glutamylcysteine synthetase by interleukin-1beta and tumor necrosis factor-alpha in mouse endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Transforming growth factor-beta1 is a potent inhibitor of glutathione synthesis in the lung epithelial cell line A549: transcriptional effect on the GSH rate-limiting enzyme gamma-glutamylcysteine synthetase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Tumor necrosis factor increases hepatocellular glutathione by transcriptional regulation of the heavy subunit chain of gamma-glutamylcysteine synthetase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Influence of cluster formation of acidic phospholipids on decrease in the affinity for ATP of DnaA protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Glutathione regulation in rat hepatic stellate cells. Comparative studies in primary culture and in liver injury in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Changes in glutathione homeostasis during liver regeneration in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Glutathione homeostasis in human hepatic cells: overexpression of gamma-glutamylcysteine synthetase gene in cell lines resistant to buthionine sulfoximine, an inhibitor of glutathione synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Cellular balance of glutathione levels through the expression of gamma-glutamylcysteine synthetase and glutathione thiol transferase genes in human hepatic cells resistant to a glutathione poison

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Cadmium resistance in A549 cells correlates with elevated glutathione content but not antioxidant enzymatic activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Expression of gamma-glutamylcysteine synthetase (gamma-GCS) and multidrug resistance-associated protein (MRP), but not human canalicular multispecific organic anion transporter (cMOAT), genes correlates with exposure of human lung cancers to platinu

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Co-ordinated over-expression of the MRP and gamma-glutamylcysteine synthetase genes, but not MDR1, correlates with doxorubicin resistance in human malignant mesothelioma cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Coordinate changes in expression of protective genes in drug-resistant cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

The electrophile counterattack response: protection against neoplasia and toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Chemoprotection against cancer by phase 2 enzyme induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Chemical and molecular regulation of enzymes that detoxify carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Activation of heat shock transcription factors by delta 12-prostaglandin J2 and its inhibition by intracellular glutathione

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Human NAD(P)H:quinone oxidoreductase (NQO1) gene structure and induction by dioxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Regulation of [Ah] gene battery enzymes and glutathione levels by 5,10-dihydroindeno[1,2-b]indole in mouse hepatoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Characterisation of gamma-glutamylcysteine synthetase-heavy subunit promoter: a critical role for AP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

The rat quinone reductase antioxidant response element. Identification of the nucleotide sequence required for basal and inducible activity and detection of antioxidant response element-binding proteins in hepatoma and non-hepatoma cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Functional antioxidant responsive elements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Antioxidant response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Identification of jun-B as third member in human antioxidant response element-nuclear proteins complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Two adjacent AP-1-like binding sites form the electrophile-responsive element of the murine glutathione S-transferase Ya subunit gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

ARE- and TRE-mediated regulation of gene expression. Response to xenobiotics and antioxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

The world according to Maf

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Human small Maf proteins form heterodimers with CNC family transcription factors and recognize the NF-E2 motif

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Dependence of globin gene expression in mouse erythroleukemia cells on the NF-E2 heterodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Enzyme induction by L-buthionine (S,R)-sulfoximine in cultured mouse hepatoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Oxidative stress induces the levels of a MafG homolog in hamster HA-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Disruption of c-Fos leads to increased expression of NAD(P)H:quinone oxidoreductase1 and glutathione S-transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Induction of γ-glutamylcysteine synthetase by cigarette smoke is associated with AP-1 in human alveolar epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

Transcriptional Regulation of γ-Glutamylcysteine Synthetase-Heavy Subunit by Oxidants in Human Alveolar Epithelial Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F10715760000300291

10.1080/10715760000300291

21 January 2018

Identifiers

DOI

1 reference

29 July 2017

1 reference

PubMed ID

10741850