Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein. (Q33884193)

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13 January 2020

title

Transcriptional repression of the Neurofibromatosis-1 tumor suppressor by the t(8;21) fusion protein (English)

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13 January 2020

8

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13 January 2020

author name string

Genyan Yang

1

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13 January 2020

Waleed Khalaf

2

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13 January 2020

Louis van de Locht

3

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13 January 2020

Joop H Jansen

4

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13 January 2020

Meihua Gao

5

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13 January 2020

Mary Ann Thompson

6

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13 January 2020

Bert A van der Reijden

7

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13 January 2020

Ruud Delwel

9

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13 January 2020

D Wade Clapp

10

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13 January 2020

Scott W Hiebert

11

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13 January 2020

language of work or name

English

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publication date

1 July 2005

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Molecular and Cellular Biology

13 January 2020

published in

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13 January 2020

volume

25

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issue

14

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13 January 2020

page(s)

5869-5879

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AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.

13 January 2020

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Somatic inactivation of Nf1 in hematopoietic cells results in a progressive myeloproliferative disorder

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The inv(16) fusion protein associates with corepressors via a smooth muscle myosin heavy-chain domain

5 July 2018

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Retroviral-mediated expression of recombinant Fancc enhances the repopulating ability of Fancc-/- hematopoietic stem cells and decreases the risk of clonal evolution

5 July 2018

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5 July 2018

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ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain

5 July 2018

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Dichotomy of AML1-ETO functions: growth arrest versus block of differentiation

5 July 2018

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Hyperactivation of p21(ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro

5 July 2018

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AML1-ETO downregulates the granulocytic differentiation factor C/EBPalpha in t(8;21) myeloid leukemia.

5 July 2018

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Neurofibromatosis 1 (NF1) heterozygosity results in a cell-autonomous growth advantage for astrocytes

5 July 2018

1 reference

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Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

5 July 2018

1 reference

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Dimerization with PEBP2beta protects RUNX1/AML1 from ubiquitin-proteasome-mediated degradation

5 July 2018

1 reference

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Multiple regions of ETO cooperate in transcriptional repression

5 July 2018

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Neurofibromin GTPase-activating protein-related domains restore normal growth in Nf1-/- cells

5 July 2018

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p53-independent functions of the p19(ARF) tumor suppressor

5 July 2018

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Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation

5 July 2018

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Genetic and biochemical evidence that haploinsufficiency of the Nf1 tumor suppressor gene modulates melanocyte and mast cell fates in vivo

5 July 2018

1 reference

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A mechanism of repression by acute myeloid leukemia-1, the target of multiple chromosomal translocations in acute leukemia

5 July 2018

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Malignant transformation of neurofibromas in neurofibromatosis 1 is associated with CDKN2A/p16 inactivation

5 July 2018

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The role of chromosome translocations in leukemogenesis.

5 July 2018

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Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

5 July 2018

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The inv(16) encodes an acute myeloid leukemia 1 transcriptional corepressor

5 July 2018

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Solution structure of core binding factor beta and map of the CBF alpha binding site

5 July 2018

1 reference

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Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains

5 July 2018

1 reference

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The leukemic protein core binding factor beta (CBFbeta)-smooth-muscle myosin heavy chain sequesters CBFalpha2 into cytoskeletal filaments and aggregates

5 July 2018

1 reference

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Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors

5 July 2018

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Cytoplasmic sequestration of the polyomavirus enhancer binding protein 2 (PEBP2)/core binding factor alpha (CBFalpha) subunit by the leukemia-related PEBP2/CBFbeta-SMMHC fusion protein inhibits PEBP2/CBF-mediated transactivation

5 July 2018

1 reference

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Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1

5 July 2018

1 reference

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The MYND motif is required for repression of basal transcription from the multidrug resistance 1 promoter by the t(8;21) fusion protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1168824

The t(8;21) fusion product, AML-1-ETO, associates with C/EBP-alpha, inhibits C/EBP-alpha-dependent transcription, and blocks granulocytic differentiation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1168824

Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1168824

Repression of the NF1 gene by Tax may expain the development of neurofibromas in human T-lymphotropic virus type 1 transgenic mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1168824

CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1168824

Nf1 deficiency causes Ras-mediated granulocyte/macrophage colony stimulating factor hypersensitivity and chronic myeloid leukaemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1168824

Identification of AML-1 and the (8;21) translocation protein (AML-1/ETO) as sequence-specific DNA-binding proteins: the runt homology domain is required for DNA binding and protein-protein interactions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1168824

Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1168824

Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1168824

The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1168824

Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1168824

Tumour predisposition in mice heterozygous for a targeted mutation in Nf1

5 July 2018

1 reference

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PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1168824

Functional domains of the t(8;21) fusion protein, AML-1/ETO.

5 July 2018

1 reference

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The product of the c-ets-1 proto-oncogene and the related Ets2 protein act as transcriptional activators of the long terminal repeat of human T cell leukemia virus HTLV-1

5 July 2018

1 reference

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Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients

5 July 2018

1 reference

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Identification and characterization of the neurofibromatosis type 1 protein product

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1168824

Identification of the neurofibromatosis type 1 gene product

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1168824

Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1168824

Mitogenic signaling by colony-stimulating factor 1 and ras is suppressed by the ets-2 DNA-binding domain and restored by myc overexpression

5 July 2018

1 reference

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Neurofibromin, a predominantly neuronal GTPase activating protein in the adult, is ubiquitously expressed during development

5 July 2018

1 reference

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KIT activating mutations: incidence in adult and pediatric acute myeloid leukemia, and identification of an internal tandem duplication

5 July 2018

1 reference

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Lymphoproliferative defects in mice lacking the expression of neurofibromin: functional and biochemical consequences of Nf1 deficiency in T-cell development and function

29 October 2018

1 reference

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Heterozygous PU.1 mutations are associated with acute myeloid leukemia.

29 October 2018

1 reference

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The t(8;21) fusion protein, AML1 ETO, specifically represses the transcription of the p14(ARF) tumor suppressor in acute myeloid leukemia.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1168824

Mutations of the NF1 gene in children with juvenile myelomonocytic leukemia without clinical evidence of neurofibromatosis, type 1.

29 October 2018

1 reference

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Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1168824

DNA sequences in the promoter region of the NF1 gene are highly conserved between human and mouse.

29 October 2018

1 reference

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Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors

29 October 2018

1 reference

12 December 2020

Mutations within the FLR exon of NF1 are rare in myelodysplastic syndromes and acute myelocytic leukemias

1 reference

12 December 2020

Rare occurrence of mutations of the FLR exon of the neurofibromatosis 1 (NF1) gene in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML)

1 reference

12 December 2020

Absence of rearrangement of the neurofibromatosis 1 (NF1) gene in myelodysplastic syndromes and acute myeloid leukemia

1 reference

12 December 2020

Neurofibromatosis 1 gene (NF1) mutation is a rare genetic event in myelodysplastic syndrome regardless of the disease progression

1 reference

12 December 2020

Loss of neurofibromatosis-1 and p19(ARF) cooperate to induce a multiple tumor phenotype

1 reference

12 December 2020

Variation in gene expression within and among natural populations

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12 December 2020

The prognostic significance of bone marrow levels of neurofibromatosis-1 protein and ras oncogene mutations in patients with acute myeloid leukemia and myelodysplastic syndrome

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12 December 2020

Natural variation in human gene expression assessed in lymphoblastoid cells

1 reference

12 December 2020

10.1128/MCB.25.14.5869-5879.2005

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15988004%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

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13 January 2020

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