The protease domain increases the translocation stepping efficiency of the hepatitis C virus NS3-4A helicase (Q33885300)

29 July 2017

The protease domain increases the translocation stepping efficiency of the hepatitis C virus NS3-4A helicase (English)

1 reference

29 July 2017

1 reference

1 reference

Vaishnavi Rajagopal

1

1 reference

29 July 2017

Madhura Gurjar

series ordinal

2

1 reference

29 July 2017

Mikhail K Levin

series ordinal

3

1 reference

29 July 2017

Smita S Patel

series ordinal

4

1 reference

29 July 2017

language of work or name

English

0 references

publication date

2 April 2010

1 reference

Journal of Biological Chemistry

29 July 2017

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29 July 2017

285

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29 July 2017

23

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29 July 2017

17821-17832

1 reference

Investigation of Translocation, DNA Unwinding, and Protein Displacement by NS3h, the Helicase Domain from the Hepatitis C Virus Helicase

29 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Model-based global analysis of heterogeneous experimental data using gfit

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Rule-based modeling of biochemical systems with BioNetGen

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

The NS4A Protein of Hepatitis C Virus Promotes RNA-Coupled ATP Hydrolysis by the NS3 Helicase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Establishing a Mechanistic Basis for the Large Kinetic Steps of the NS3 Helicase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Hepatitis C Viral NS3-4A Protease Activity Is Enhanced by the NS3 Helicase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Coupling of DNA unwinding to nucleotide hydrolysis in a ring-shaped helicase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Non-hexameric DNA helicases and translocases: mechanisms and regulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

DEAD-box proteins unwind duplexes by local strand separation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

NS3 helicase actively separates RNA strands and senses sequence barriers ahead of the opening fork

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Spring-loaded mechanism of DNA unwinding by hepatitis C virus NS3 helicase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

The NS3 Helicase and NS5B-to-3'X Regions Are Important for Efficient Hepatitis C Virus Strain JFH-1 Replication in Huh7 Cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

A nonuniform stepping mechanism for E. coli UvrD monomer translocation along single-stranded DNA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Development of fluorescent biosensors for probing the function of motor proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Functional and therapeutic analysis of hepatitis C virus NS3.4A protease control of antiviral immune defense

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

5 July 2018

Mechanisms of helicases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Hepatitis C virus subgenomic replicon requires an active NS3 RNA helicase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Multiple full-length NS3 molecules are required for optimal unwinding of oligonucleotide DNA in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Mechanism of ATP-dependent translocation of E.coli UvrD monomers along single-stranded DNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

ATP-dependent translocation of proteins along single-stranded DNA: models and methods of analysis of pre-steady state kinetics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Hepatitis C virus non-structural protein NS3 interacts with LMP7, a component of the immunoproteasome, and affects its proteasome activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Protein displacement by an assembly of helicase molecules aligned along single-stranded DNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

The nonstructural protein 3 protease/helicase requires an intact protease domain to unwind duplex RNA efficiently

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Hepatitis C Virus NS3 ATPases/Helicases from Different Genotypes Exhibit Variations in Enzymatic Properties

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Hepatitis C virus NS3 ATPase/helicase: an ATP switch regulates the cooperativity among the different substrate binding sites

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

The hepatitis C viral NS3 protein is a processive DNA helicase with cofactor enhanced RNA unwinding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Solution structure and backbone dynamics of an engineered arginine-rich subdomain 2 of the hepatitis C virus NS3 RNA helicase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Hepatitis C virus NS3 and simian virus 40 T antigen helicases displace streptavidin from 5'-biotinylated oligonucleotides but not from 3'-biotinylated oligonucleotides: evidence for directional bias in translocation on single-stranded DNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Stimulation of the weak ATPase activity of human hsp90 by a client protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Uncoupling DNA translocation and helicase activity in PcrA: direct evidence for an active mechanism.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

The NS3/4A proteinase of the hepatitis C virus: unravelling structure and function of an unusual enzyme and a prime target for antiviral therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

An oligomeric form of E. coli UvrD is required for optimal helicase activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

A novel recombinant single-chain hepatitis C virus ns3-ns4a protein with improved helicase activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

DNA helicases displace streptavidin from biotin-labeled oligonucleotides

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Characterization and mutational analysis of the helicase and NTPase activities of hepatitis C virus full-length NS3 protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Mechanism of inorganic phosphate interaction with phosphate binding protein from Escherichia coli.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

A kinetic analysis of the oligonucleotide-modulated ATPase activity of the helicase domain of the NS3 protein from hepatitis C virus. The first cycle of interaction of ATP with the enzyme is unique

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Hepatitis C virus NS3 RNA helicase domain with a bound oligonucleotide: the crystal structure provides insights into the mode of unwinding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Kinetics of Nucleoside Triphosphate Cleavage and Phosphate Release Steps by Associated Rabbit Skeletal Actomyosin, Measured Using a Novel Fluorescent Probe for Phosphate †

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

A steady-state and pre-steady-state kinetic analysis of the NTPase activity associated with the hepatitis C virus NS3 helicase domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Kinetic parameters of the translocation of bacteriophage T4 gene 41 protein helicase on single-stranded DNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Kinetic and structural analyses of hepatitis C virus polyprotein processing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

Direct, real-time measurement of rapid inorganic phosphate release using a novel fluorescent probe and its application to actomyosin subfragment 1 ATPase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

NS3-4A of hepatitis C virus is a chymotrypsin-like protease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

NS3 is a serine protease required for processing of hepatitis C virus polyprotein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2878546

DNA helicase activity of the hepatitis C virus nonstructural protein 3.

5 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.114785

Helicase from hepatitis C virus, energetics of DNA binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.114785

The serine protease domain of hepatitis C viral NS3 activates RNA helicase activity by promoting the binding of RNA substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.114785

Bacillus stearothermophilus PcrA monomer is a single-stranded DNA translocase but not a processive helicase in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.114785

The DEAD-box protein Ded1 unwinds RNA duplexes by a mode distinct from translocating helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.114785

The functional interaction of the hepatitis C virus helicase molecules is responsible for unwinding processivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.114785

A Brownian motor mechanism of translocation and strand separation by hepatitis C virus helicase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.114785

Kinetic measurement of the step size of DNA unwinding by Escherichia coli UvrD helicase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.114785

DNA unwinding step-size of E. coli RecBCD helicase determined from single turnover chemical quenched-flow kinetic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.114785

The helicase from hepatitis C virus is active as an oligomer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.114785

T7 DNA helicase: a molecular motor that processively and unidirectionally translocates along single-stranded DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.114785

F1-ATPase changes its conformations upon phosphate release

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.114785

ATP binding modulates the nucleic acid affinity of hepatitis C virus helicase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.114785

Kinetic theory of ATP-driven translocases on one-dimensional polymer lattices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.114785

Demonstration of unidirectional single-stranded DNA translocation by PcrA helicase: measurement of step size and translocation speed

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.114785

Nucleic acid unwinding by hepatitis C virus and bacteriophage t7 helicases is sensitive to base pair stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.114785

Two-state model for helicase translocation and unwinding of nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.114785

Hepatitis C virus proteins interfere with the activation of chemokine gene promoters and downregulate chemokine gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.114785

Hepatitis C--global prevalence (update)

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20363755

12 December 2020

inferred from PubMed ID database lookup

Bacteriophage T4 Dda helicase translocates in a unidirectional fashion on single-stranded DNA

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20363755

12 December 2020

inferred from PubMed ID database lookup

Cardif: a protein central to innate immunity is inactivated by the HCV NS3 serine protease

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20363755

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1074/JBC.M110.114785

1 reference

release_ljorotddpbdbjeaicuttr64aue

29 July 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ljorotddpbdbjeaicuttr64aue

24 November 2022

mapped directly with Wikidata item

PMCID

2878546

1 reference

29 July 2017

1 reference