Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes. (Q33885674)

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4 February 2020

review article

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title

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes (English)

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4 February 2020

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T-cell acute lymphoblastic leukemia

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6

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7

Trang Hoang

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3

Sabine Herblot

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4

Peter D Aplan

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4 February 2020

author name string

Mathieu Tremblay

series ordinal

1

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4 February 2020

Cédric S Tremblay

series ordinal

2

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4 February 2020

Josée Hébert

series ordinal

5

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publication date

1 June 2010

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4 February 2020

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4 February 2020

volume

24

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issue

11

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4 February 2020

page(s)

1093-1105

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The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal

4 February 2020

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p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis

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Beta-catenin stabilization stalls the transition from double-positive to single-positive stage and predisposes thymocytes to malignant transformation

5 July 2018

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The multifaceted role of Notch in cancer

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Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc

5 July 2018

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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

5 July 2018

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E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment

5 July 2018

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Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia

5 July 2018

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Notch1-dependent lymphomagenesis is assisted by but does not essentially require pre-TCR signaling

5 July 2018

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Notch3 and pre-TCR interaction unveils distinct NF-kappaB pathways in T-cell development and leukemia.

5 July 2018

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Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability

5 July 2018

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5 July 2018

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5 July 2018

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T cell acute lymphoblastic leukemia/lymphoma: a human cancer commonly associated with aberrant NOTCH1 signaling

5 July 2018

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5 July 2018

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Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes

5 July 2018

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5 July 2018

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Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice

5 July 2018

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No requirement for V(D)J recombination in p53-deficient thymic lymphoma

5 July 2018

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5 July 2018

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5 July 2018

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An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma

5 July 2018

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Hypothesis: why do so many lymphocytes respond to major histocompatibility antigens?

5 July 2018

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5 July 2018

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Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals.

29 October 2018

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NOTCH1 mutation can be an early, prenatal genetic event in T-ALL.

29 October 2018

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Pre-TCR expression cooperates with TEL-JAK2 to transform immature thymocytes and induce T-cell leukemia.

29 October 2018

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Notch signaling controls the generation and differentiation of early T lineage progenitors

29 October 2018

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FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression

29 October 2018

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Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity

29 October 2018

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scid Thymocytes with TCRbeta gene rearrangements are targets for the oncogenic effect of SCL and LMO1 transgenes.

29 October 2018

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The CD2-scl transgene alters the phenotype and frequency of T-lymphomas in N-ras transgenic or p53 deficient mice.

29 October 2018

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T cell tumours of disparate phenotype in mice transgenic for Rbtn-2

29 October 2018

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SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression

29 October 2018

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12 December 2020

Of mice and men: how an oncogene transgresses the limits and predisposes to T cell acute lymphoblastic leukemia

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12 December 2020

Ectopic expression of TAL-1 protein in Ly-6E.1-htal-1 transgenic mice induces defects in B- and T-lymphoid differentiation

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12 December 2020

A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development

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12 December 2020

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12 December 2020

T-cell-directed TAL-1 expression induces T-cell malignancies in transgenic mice

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12 December 2020

Suppression of p53 by Notch in lymphomagenesis: implications for initiation and regression

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12 December 2020

Identifiers

DOI

10.1101/GAD.1897910

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20516195%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20516195%20AND%20SRC:MED&resulttype=core&format=json

4 February 2020

1 reference