Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells. (Q33893102)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713725%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

title

Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713725%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

1 reference

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713725%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

author name string

Murphy KM

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713725%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Ranganathan V

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713725%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Farnsworth ML

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713725%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Kavallaris M

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713725%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

publication date

1 January 2000

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713725%20AND%20SRC:MED&resulttype=core&format=json

Cell Death & Differentiation

4 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713725%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713725%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

page(s)

102-111

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713725%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10713725%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4400597

4 November 2019

exact match

0 references

cites work

Apoptosis in the pathogenesis and treatment of disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

The molecular biology of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Caspases: the executioners of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Macromolecular substrates for the ICE-like proteases during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Protease activation during apoptosis: death by a thousand cuts?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Differential requirement for caspase 9 in apoptotic pathways in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

BCL-2 family: regulators of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

The proto-oncogene Bcl-2 and its role in regulating apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Double identity for proteins of the Bcl-2 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Mitochondria and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Movement of Bax from the cytosol to mitochondria during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Bax directly induces release of cytochrome c from isolated mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Expression of Bcl-2 in human epithelial tumor (HeLa) cells enhances clonogenic survival following exposure to 5-fluoro-2'-deoxyuridine or staurosporine, but not following exposure to etoposide or doxorubicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Regulated targeting of BAX to mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Conformation of the Bax C-terminus regulates subcellular location and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Bax membrane insertion during Fas(CD95)-induced apoptosis precedes cytochrome c release and is inhibited by Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597

Redistribution of Bax from cytosol to membranes is induced by apoptotic stimuli and is an early step in the apoptotic pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4400597