In vitro potency, pharmacokinetic profiles, and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus (Q33895826)

29 July 2017

In vitro potency, pharmacokinetic profiles, and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus (English)

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29 July 2017

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Yulia Vugmeyster

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29 July 2017

Heath Guay

2

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29 July 2017

Pamela Szklut

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29 July 2017

Ming D Qian

4

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29 July 2017

Macy Jin

5

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29 July 2017

Angela Widom

6

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29 July 2017

Vikki Spaulding

7

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29 July 2017

Frann Bennett

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29 July 2017

Leslie Lowe

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29 July 2017

Tatyana Andreyeva

10

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29 July 2017

David Lowe

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29 July 2017

Steven Lane

12

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29 July 2017

George Thom

13

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29 July 2017

Viia Valge-Archer

14

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29 July 2017

Davinder Gill

15

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29 July 2017

Deborah Young

16

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29 July 2017

Laird Bloom

17

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29 July 2017

language of work or name

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23 May 2010

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29 July 2017

Monoclonal Antibodies

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29 July 2017

2

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29 July 2017

335-346

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29 July 2017

3

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Interleukin 21 as a target of intervention in autoimmune disease

29 July 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

Modelling the human immune response: performance of a 1011 human antibody repertoire against a broad panel of therapeutically relevant antigens

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

Fully human antibodies from transgenic mouse and phage display platforms

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

A fundamental role for interleukin-21 in the generation of T follicular helper cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

T follicular helper (TFH) cells in normal and dysregulated immune responses

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

The existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogue

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

Biologic therapies in rheumatology: lessons learned, future directions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

Potent antibody therapeutics by design

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

Expression of interleukin-21 receptor in epidermis from patients with systemic sclerosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

A critical role for IL-21 in regulating immunoglobulin production

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

Use of genetic knockouts to modulate disease expression in a murine model of lupus, MRL/lpr mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

Isolation of high affinity human antibodies directly from large synthetic repertoires.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

Selection of phage antibodies by binding affinity. Mimicking affinity maturation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

Etiology and pathogenesis of a spontaneous lupus-like syndrome in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2881259

Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis.

5 July 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.3.11850

Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.3.11850

Regulation of gut inflammation and th17 cell response by interleukin-21.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.3.11850

Interleukin-13 neutralization by two distinct receptor blocking mechanisms reduces immunoglobulin E responses and lung inflammation in cynomolgus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.3.11850

A simple high-throughput purification method for hit identification in protein screening.

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.3.11850

Selection of phage antibodies by binding affinity

21 January 2018

1 reference

https://api.crossref.org/works/10.4161%2FMABS.2.3.11850

Hypercatabolism of IgG in mice with lupus-like syndrome

21 January 2018

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12 December 2020

A Functional Role for Interleukin-21 in Promoting the Synthesis of the T-Cell Chemoattractant, MIP-3α, by Gut Epithelial Cells

1 reference

12 December 2020

Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis

1 reference

12 December 2020

Interleukin 21 contributes to the mucosal T helper cell type 1 response in coeliac disease

1 reference

12 December 2020

Identifiers

DOI

10.4161/MABS.2.3.11850

1 reference

29 July 2017

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29 July 2017

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