Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets. (Q33895889)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15994237%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

title

Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets (English)

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13 January 2020

4

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13 January 2020

author name string

Nicolas Prévost

1

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13 January 2020

Donna S Woulfe

2

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13 January 2020

Hong Jiang

3

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13 January 2020

Patrizia Marchese

5

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13 January 2020

Zaverio M Ruggeri

6

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13 January 2020

Lawrence F Brass

7

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13 January 2020

language of work or name

English

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publication date

1 July 2005

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Proceedings of the National Academy of Sciences of the United States of America

13 January 2020

published in

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13 January 2020

volume

102

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13 January 2020

issue

28

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13 January 2020

page(s)

9820-9825

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Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy

13 January 2020

cites work

1 reference

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Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase. Role of Rho family small GTPases

5 July 2018

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Eph receptors, ephrins, and synaptic function

5 July 2018

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Mer receptor tyrosine kinase signaling participates in platelet function

5 July 2018

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Mechanotransduction through growth-factor shedding into the extracellular space

5 July 2018

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Src kinase activation by direct interaction with the integrin β cytoplasmic domain

5 July 2018

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Contact-dependent signaling during the late events of platelet activation.

5 July 2018

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Signaling events underlying thrombus formation

5 July 2018

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The role of the Eph-ephrin signalling system in the regulation of developmental patterning

5 July 2018

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Mechanisms and functions of Eph and ephrin signalling

5 July 2018

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Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred

5 July 2018

1 reference

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Relationships between Rap1b, affinity modulation of integrin alpha IIbbeta 3, and the actin cytoskeleton

5 July 2018

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Ephrins are not only unattractive

5 July 2018

1 reference

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Signaling downstream of Eph receptors and ephrin ligands

5 July 2018

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Eph receptors and ephrin ligands. essential mediators of vascular development.

5 July 2018

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Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis.

5 July 2018

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An ephrin-A-dependent signaling pathway controls integrin function and is linked to the tyrosine phosphorylation of a 120-kDa protein.

5 July 2018

1 reference

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Ephrin-A5 modulates cell adhesion and morphology in an integrin-dependent manner

5 July 2018

1 reference

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Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

5 July 2018

1 reference

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An Eph receptor regulates integrin activity through R-Ras

5 July 2018

1 reference

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Surface densities of ephrin-B1 determine EphB1-coupled activation of cell attachment through alphavbeta3 and alpha5beta1 integrins

5 July 2018

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Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis

5 July 2018

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Crystal structure of the ligand-binding domain of the receptor tyrosine kinase EphB2

5 July 2018

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Genetic analysis of the role of Eph receptors in the development of the mammalian nervous system

5 July 2018

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Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis

5 July 2018

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Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor

5 July 2018

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Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity

5 July 2018

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Targeting the EphA4 receptor in the nervous system with biologically active peptides

5 July 2018

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Signaling by ephrinB1 and Eph kinases in platelets promotes Rap1 activation, platelet adhesion, and aggregation via effector pathways that do not require phosphorylation of ephrinB1.

29 October 2018

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Integrin cytoplasmic tyrosine motif is required for outside-in alphaIIbbeta3 signalling and platelet function

29 October 2018

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Contribution of distinct adhesive interactions to platelet aggregation in flowing blood

29 October 2018

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12 December 2020

Beta3 tyrosine phosphorylation in alphaIIbbeta3 (platelet membrane GP IIb-IIIa) outside-in integrin signaling

1 reference

12 December 2020

Biochemical characterization of plasma membranes and intracellular membranes isolated from human platelets using Percoll gradients

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12 December 2020

Effect of platelet activation on the conformation of the plasma membrane glycoprotein IIb-IIIa complex

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12 December 2020

Design and construction of a linear shear stress flow chamber

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12 December 2020

Tyrosine phosphorylation of the beta3 cytoplasmic domain mediates integrin-cytoskeletal interactions

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0404065102

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13 January 2020

0 references

1 reference

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13 January 2020

1 reference