Biologic functions and signaling of the interleukin-4 receptor complexes (Q33897187)

29 July 2017

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title

Biologic functions and signaling of the interleukin-4 receptor complexes (English)

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29 July 2017

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Gessner A

1

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PubMed ID

10776786

29 July 2017

Röllinghoff M

series ordinal

2

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29 July 2017

1 January 2000

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29 July 2017

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29 July 2017

201

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29 July 2017

3-4

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29 July 2017

285-307

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IL-4: role in disease and regulation of production

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Modulation of macrophage function by transforming growth factor beta, interleukin-4, and interleukin-10.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Neutralizing antibody to interleukin 4 induces systemic protection and T helper type 1-associated immunity in murine candidiasis

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Cure of murine candidiasis by recombinant soluble interleukin-4 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Disruption of the murine IL-4 gene blocks Th2 cytokine responses.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

The Th1/Th2 paradigm and experimental murine leishmaniasis

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Constitutive expression of interleukin (IL)-4 in vivo causes autoimmune-type disorders in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Functional diversity of helper T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Interleukin 13 induces interleukin 4-independent IgG4 and IgE synthesis and CD23 expression by human B cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Interleukin-13: central mediator of allergic asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Requirement for IL-13 independently of IL-4 in experimental asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

The murine interleukin-4 receptor: molecular cloning and characterization of secreted and membrane bound forms.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Expression cloning of a cDNA encoding the murine interleukin 4 receptor based on ligand binding

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Human interleukin 4 receptor confers biological responsiveness and defines a novel receptor superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Molecular cloning of a cDNA encoding the human interleukin 4 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Involvement of the interleukin-2 receptor gamma subunit in interleukin-4-dependent activation of mouse hematopoietic cells and splenic B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

X-SCID B cell responses to interleukin-4 and interleukin-13 are mediated by a receptor complex that includes the interleukin-4 receptor alpha chain (p140) but not the gamma c chain

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Design of human interleukin-4 antagonists inhibiting interleukin-4-dependent and interleukin-13-dependent responses in T-cells and B-cells with high efficiency

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

An interleukin 4 (IL-4) mutant protein inhibits both IL-4 or IL-13-induced human immunoglobulin G4 (IgG4) and IgE synthesis and B cell proliferation: support for a common component shared by IL-4 and IL-13 receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

A murine interleukin-4 antagonistic mutant protein completely inhibits interleukin-4-induced cell proliferation, differentiation, and signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

An immune cell-selective interleukin 4 agonist

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Interleukin-4 receptor signalling mechanisms and their biological significance

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

The IL-4 receptor: signaling mechanisms and biologic functions

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Jak1 expression is required for mediating interleukin-4-induced tyrosine phosphorylation of insulin receptor substrate and Stat6 signaling molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinases

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Homodimerization of the human interleukin 4 receptor alpha chain induces Cepsilon germline transcripts in B cells in the absence of the interleukin 2 receptor gamma chain

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Mouse macrophage development in the absence of the common γ chain: defining receptor complexes responsible for IL-4 and IL-13 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

The rat interleukin 4 receptor: coevolution of ligand and receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

An interleukin-4-induced transcription factor: IL-4 Stat

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Essential role of Stat6 in IL-4 signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

IL-13, IL-4Ralpha, and Stat6 are required for the expulsion of the gastrointestinal nematode parasite Nippostrongylus brasiliensis.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Signal transducer and activator of transcription factor 6 (Stat6)-deficient mice are protected from antigen-induced airway hyperresponsiveness and mucus production

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Regulation of interleukin 4-mediated signaling by naturally occurring dominant negative and attenuated forms of human Stat6.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

IL4 and IL13 receptors share the γc chain and activate STAT6, STAT3 and STAT5 proteins in normal human B cells

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Activation of STAT5 by IL-4 relies on Janus kinase function but not on receptor tyrosine phosphorylation, and can contribute to both cell proliferation and gene regulation

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Role of IRS-2 in insulin and cytokine signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

The 60-kDa phosphotyrosine protein in insulin-treated adipocytes is a new member of the insulin receptor substrate family.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Evidence for a role of phosphatidylinositol 3-kinase in IL-4-induced germline C epsilon transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Interleukin-4 activates two distinct pathways of phosphatidylinositol-3 kinase in the same cells

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Hemopoietic growth factors with the exception of interleukin-4 activate the p38 mitogen-activated protein kinase pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

MAP kinase pathways as a route for regulatory mechanisms of IL-10 and IL-4 which inhibit COX-2 expression in human monocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Interleukin-4 induces activation of mitogen-activated protein kinase and phosphorylation of shc in human keratinocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Soluble receptors for cytokines and growth factors: generation and biological function

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Soluble receptors in human disease

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

A soluble form of the interleukin 4 receptor in biological fluids

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

A soluble, high-affinity, interleukin-4-binding protein is present in the biological fluids of mice

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Increased levels of soluble interleukin-4 receptor in the sera of patients with visceral leishmaniasis.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

A recombinant extracellular domain of the human interleukin 4 receptor inhibits the biological effects of interleukin 4 on T and B lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Evidence that natural murine soluble interleukin 4 receptors may act as transport proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Inhibition of allergen-induced IgE and IgG1 production by soluble IL-4 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Prevention of the development of immediate hypersensitivity and airway hyperresponsiveness following in vivo treatment with soluble IL-4 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Regulation of the expression of the soluble and membrane forms of the murine IL-4 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Linked in vivo expression of soluble interleukin-4 receptor and interleukin-4 in murine schistosomiasis

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Soluble human interleukin-4 receptor is produced by activated T cells under the control of metalloproteinases.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Molecular characterization and functional analysis of murine interleukin 4 receptor allotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

The interleukin-4 receptor variant Q576R in hyper-IgE syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

The IL-4 receptor alpha-chain variant Q576R is strongly associated with decreased kidney allograft survival

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Definition of human interleukin-4 receptor alpha chain haplotypes and allelic association with atopy markers.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Lack of association of atopy/asthma and the interleukin-4 receptor alpha gene in Japanese

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma.

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Common polymorphisms in the coding part of the IL4-receptor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

Association of interleukin-4 receptor and interleukin-4 promoter gene polymorphisms with systemic lupus erythematosus

1 reference

https://api.crossref.org/works/10.1016%2FS0171-2985%2800%2980084-4

7 January 2021

10.1016/S0171-2985(00)80084-4

Identifiers

DOI

0 references

PubMed ID

10776786

1 reference

PubMed ID

10776786