Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells. (Q33904439)

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4 January 2020

title

Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells (English)

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4 January 2020

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1

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Tetsuya Okuda

7

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4 January 2020

Takeshi Urano

11

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author name string

Keiko Furukawa

2

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4 January 2020

Takanori Hayashi

3

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4 January 2020

Takeshi Hattori

4

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4 January 2020

Junji Nakano

5

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4 January 2020

Hideyuki Nakashima

6

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4 January 2020

Hideki Mizutani

8

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4 January 2020

Hisashi Hattori

9

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4 January 2020

Minoru Ueda

10

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4 January 2020

Kenneth O Lloyd

12

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4 January 2020

Koichi Furukawa

13

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4 January 2020

language of work or name

English

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publication date

22 July 2005

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Proceedings of the National Academy of Sciences of the United States of America

4 January 2020

published in

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4 January 2020

volume

102

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issue

31

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4 January 2020

page(s)

11041-11046

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Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility.

4 January 2020

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Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines

5 July 2018

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Suppression of ganglioside GD3 expression in a rat F-11 tumor cell line reduces tumor growth, angiogenesis, and vascular endothelial growth factor production.

5 July 2018

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Paxillin interactions

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Reduced cell migration, tumor growth and experimental metastasis of rat F-11 cells whose expression of GD3-synthase is suppressed

5 July 2018

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GD3 synthase gene expression in PC12 cells results in the continuous activation of TrkA and ERK1/2 and enhanced proliferation.

5 July 2018

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Integrin signalling: a new Cas(t) of characters enters the stage

5 July 2018

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Soluble collagen VI induces tyrosine phosphorylation of paxillin and focal adhesion kinase and activates the MAP kinase erk2 in fibroblasts

5 July 2018

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Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas

5 July 2018

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Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration

5 July 2018

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Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs

5 July 2018

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Human melanoma cell lines deficient in GD3 ganglioside expression exhibit altered growth and tumorigenic characteristics

5 July 2018

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Nerve growth factor stimulates the tyrosine phosphorylation of endogenous Crk-II and augments its association with p130Cas in PC-12 cells

5 July 2018

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Integrin alphavbeta3 mediates chemotactic and haptotactic motility in human melanoma cells through different signaling pathways

5 July 2018

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The tyrosinase gene codes for an antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas

5 July 2018

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GD2 ganglioside on human T-lymphotropic virus type I-infected T cells: possible activation of beta-1,4-N-acetylgalactosaminyltransferase gene by p40tax

5 July 2018

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A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner

5 July 2018

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Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody

5 July 2018

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Phase 1 trial of immunological adjuvant QS-21 with a GM2 ganglioside-keyhole limpet haemocyanin conjugate vaccine in patients with malignant melanoma

5 July 2018

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Melanoma Growth Stimulatory Activity Signaling through the Class II Interleukin-8 Receptor Enhances the Tyrosine Phosphorylation of Crk-Associated Substrate, p130, and a 70-Kilodalton Protein

5 July 2018

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Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Expression of alpha 2,8-sialyltransferase (GD3 synthase) gene in human cancer cell lines: high level expression in melanomas and up-regulation in activated T lymphocytes.

5 July 2018

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Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis

21 January 2018

1 reference

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Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells.

21 January 2018

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Suppression of lung metastasis of mouse Lewis lung cancer P29 with transfection of the ganglioside GM2/GD2 synthase gene

21 January 2018

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High expression of ganglioside alpha-2,8-sialyltransferase (GD3 synthase) gene in adult T-cell leukemia cells unrelated to the gene expression of human T-lymphotropic virus type I.

21 January 2018

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Inhibition of human melanoma cell growth in vitro by monoclonal anti-GD3-ganglioside antibody

29 October 2018

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12 December 2020

Gangliosides of normal and neoplastic human melanocytes

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12 December 2020

The melanoma growth stimulatory activity receptor consists of two proteins. Ligand binding results in enhanced tyrosine phosphorylation

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12 December 2020

Differential expression of ganglioside GD3 by human leukocytes and leukemia cells

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Identifiers

DOI

10.1073/PNAS.0503658102

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16040804%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

0 references

1 reference

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4 January 2020

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