Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy. (Q33906093)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20531415%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy (English)

1 reference

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5 February 2020

9

1 reference

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5 February 2020

author name string

K H T Paraiso

1

1 reference

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5 February 2020

I V Fedorenko

2

1 reference

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5 February 2020

L P Cantini

3

1 reference

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5 February 2020

A C Munko

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20531415%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

M Hall

5

1 reference

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5 February 2020

V K Sondak

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20531415%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

J L Messina

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20531415%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

K T Flaherty

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20531415%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

language of work or name

English

0 references

publication date

1 June 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20531415%20AND%20SRC:MED&resulttype=core&format=json

British Journal of Cancer

5 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20531415%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

volume

102

1 reference

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5 February 2020

issue

12

1 reference

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5 February 2020

page(s)

1724-1730

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20531415%20AND%20SRC:MED&resulttype=core&format=json

MEK1 mutations confer resistance to MEK and B-RAF inhibition

5 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

5 July 2018

1 reference

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Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

Integrating BRAF/MEK inhibitors into combination therapy for melanoma.

5 July 2018

1 reference

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Oncogenic BRAF(V600E) inhibits BIM expression to promote melanoma cell survival

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

BRAF silencing by short hairpin RNA or chemical blockade by PLX4032 leads to different responses in melanoma and thyroid carcinoma cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

KIT oncogenic signaling mechanisms in imatinib-resistant gastrointestinal stromal tumor: PI3-kinase/AKT is a crucial survival pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

Ki67 expression levels are a better marker of reduced melanoma growth following MEK inhibitor treatment than phospho-ERK levels.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

Tumor necrosis factor-alpha blocks apoptosis in melanoma cells when BRAF signaling is inhibited

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

Multiple signaling pathways must be targeted to overcome drug resistance in cell lines derived from melanoma metastases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

Growth factors rescue cutaneous melanoma cells from apoptosis induced by knockdown of mutated (V 600 E) B-RAF.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

A role for K-ras in conferring resistance to the MEK inhibitor, CI-1040.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

5 July 2018

Targeted cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

The RAF proteins take centre stage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

B-RAF is a therapeutic target in melanoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

V599EB-RAF is an oncogene in melanocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

A pivotal role for ERK in the oncogenic behaviour of malignant melanoma?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

Mutations of the BRAF gene in human cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2883709

The mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor AZD6244 (ARRY-142886) induces growth arrest in melanoma cells and tumor regression when combined with docetaxel

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605714

An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605714

Adhesion control of cyclin D1 and p27Kip1 levels is deregulated in melanoma cells through BRAF-MEK-ERK signaling

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.BJC.6605714

Suppression of BRAF(V599E) in human melanoma abrogates transformation

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20531415

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.BJC.6605714

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20531415%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

5 February 2020

1013296980

0 references

Fatcat ID

release_mo2rdmjcy5a4ngaepxeyhdthoe

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/mo2rdmjcy5a4ngaepxeyhdthoe

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20531415%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

20531415

1 reference