Molecular factors underlying selective vulnerability of motor neurons to neurodegeneration in amyotrophic lateral sclerosis (Q33906246)

29 July 2017

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title

Molecular factors underlying selective vulnerability of motor neurons to neurodegeneration in amyotrophic lateral sclerosis (English)

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amyotrophic lateral sclerosis

29 July 2017

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P J Shaw

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PubMed ID

10795883

29 July 2017

C J Eggett

series ordinal

2

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29 July 2017

1 March 2000

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29 July 2017

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29 July 2017

247 Suppl 1

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29 July 2017

I17-27

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Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

29 July 2017

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12 December 2020

Role of Ca2+ in toxic cell killing

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12 December 2020

Intracellular calcium parallels motoneuron degeneration in SOD-1 mutant mice.

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12 December 2020

Light and electron microscopic distribution of the AMPA receptor subunit, GluR2, in the spinal cord of control and G86R mutant superoxide dismutase transgenic mice.

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12 December 2020

Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis

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12 December 2020

Protective effect of riluzole on excitatory amino acid-mediated neurotoxicity in motoneuron-enriched cultures

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12 December 2020

Increased expression of neurofilament subunit NF-L produces morphological alterations that resemble the pathology of human motor neuron disease

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12 December 2020

Glutamate uptake is decreased tardively in the spinal cord of FALS mice.

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12 December 2020

Glutamate receptor channels: novel properties and new clones

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12 December 2020

Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions

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12 December 2020

Non-NMDA receptors in motor neuron disease (MND): a quantitative autoradiographic study in spinal cord and motor cortex using [3H]CNQX and [3H]kainate

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12 December 2020

Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice

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12 December 2020

Monosodium Glutamate Effects

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12 December 2020

Ventral root depolarization and spinal reflex augmentation by a TRH analog in rat spinal cord

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12 December 2020

Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity

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12 December 2020

Immunocytochemical and ultrastructural study of Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis

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12 December 2020

High sensitivity of glutamate uptake to extracellular free arachidonic acid levels in rat cortical synaptosomes and astrocytes.

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12 December 2020

Nonverbal visual attention, but not recognition memory of learning, processes are impaired in motor neurone disease.

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12 December 2020

Cytoskeletal abnormalities in motor neuron disease. An immunocytochemical study

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12 December 2020

Determinants of neuronal vulnerability in neurodegenerative diseases.

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12 December 2020

Abnormal distribution of phosphorylated neurofilaments in neuronal degeneration induced by kainic acid

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12 December 2020

An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria

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12 December 2020

Excitotoxicity in ALS.

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12 December 2020

Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors: a molecular determinant of selective vulnerability in amyotrophic lateral sclerosis.

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12 December 2020

Age-dependent penetrance of disease in a transgenic mouse model of familial amyotrophic lateral sclerosis

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12 December 2020

Phosphorylated high molecular weight neurofilament protein in lower motor neurons in amyotrophic lateral sclerosis and other neurodegenerative diseases involving ventral horn cells

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12 December 2020

Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced

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12 December 2020

Dementia and aphasia in motor neuron disease: an underrecognised association?

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12 December 2020

Expression of the glial glutamate transporter EAAT2 in the human CNS: an immunohistochemical study

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12 December 2020

The quantitative autoradiographic distribution of [3H]MK-801 binding sites in the normal human brainstem in relation to motor neuron disease.

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12 December 2020

The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray

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12 December 2020

A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease

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12 December 2020

SOD1 mutation is associated with accumulation of neurofilaments in amyotrophic lateral sclerosis.

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12 December 2020

Dynamics of neuronal intermediate filaments: a developmental perspective

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12 December 2020

Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis

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12 December 2020

Neurotrophic survival molecules for motoneurons: an embarrassment of riches

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12 December 2020

Do defects in mitochondrial energy metabolism underlie the pathology of neurodegenerative diseases?

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12 December 2020

Quantitative immunocytochemical analysis of the spinal cord in G86R superoxide dismutase transgenic mice: neurochemical correlates of selective vulnerability

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12 December 2020

Phosphorylation of neurofilaments is altered in amyotrophic lateral sclerosis

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12 December 2020

Cytopathology of amyotrophic lateral sclerosis

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12 December 2020

Superoxide dismutase catalyzes nitration of tyrosines by peroxynitrite in the rod and head domains of neurofilament-L.

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12 December 2020

The role of calcium-binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis

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12 December 2020

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12 December 2020

ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.

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12 December 2020

Low expression of GluR2 AMPA receptor subunit protein by human motor neurons

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12 December 2020

Selective loss of neurofilament proteins after exposure of differentiated human IMR-32 neuroblastoma cells to oxidative stress

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12 December 2020

The expression of the glial glutamate transporter protein EAAT2 in motor neuron disease: an immunohistochemical study.

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12 December 2020

Glutamate receptor update

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12 December 2020

A role for Na+-dependent Ca2+ extrusion in protection against neuronal excitotoxicity

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12 December 2020

Pathological implications of nitric oxide, superoxide and peroxynitrite formation

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12 December 2020

Reappraisal of amyotrophic lateral sclerosis with dementia

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12 December 2020

Accumulation of phosphorylated neurofilaments in anterior horn motoneurons of amyotrophic lateral sclerosis patients.

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12 December 2020

Glycine receptor: light microscopic autoradiographic localization with [3H]strychnine

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12 December 2020

Normal oxidative damage to mitochondrial and nuclear DNA is extensive

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12 December 2020

Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex

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12 December 2020

Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons

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12 December 2020

Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1

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12 December 2020

Amyotrophic lateral sclerosis associated with genetic abnormalities in the gene encoding Cu/Zn superoxide dismutase: molecular pathology of five new cases, and comparison with previous reports and 73 sporadic cases of ALS.

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12 December 2020

Immunocytochemical study of the distribution of the free radical scavenging enzymes CU/ZN superoxide dismutase (SOD1); MN superoxide dismutase (MN SOD) and catalase in the normal human spinal cord and in motor neuron disease

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12 December 2020

The GluR2 (GluR-B) hypothesis: Ca(2+)-permeable AMPA receptors in neurological disorders

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12 December 2020

Decreased cytochrome c oxidase activity but unchanged superoxide dismutase and glutathione peroxidase activities in the spinal cords of patients with amyotrophic lateral sclerosis

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12 December 2020

Excitatory amino acid neurotoxicity and neurodegenerative disease

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12 December 2020

Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis

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12 December 2020

Progressive neuronopathy in transgenic mice expressing the human neurofilament heavy gene: a mouse model of amyotrophic lateral sclerosis

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12 December 2020

N-methyl-D-aspartate (NMDA) receptors in the spinal cord and motor cortex in motor neuron disease: a quantitative autoradiographic study using [3H]MK-801.

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12 December 2020

Amyotrophic lateral sclerosis: oxidative energy metabolism and calcium homeostasis in peripheral blood lymphocytes.

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12 December 2020

Selective and asymmetric vulnerability of corticospinal and spinocerebellar tracts in motor neuron disease

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12 December 2020

Glutamate, excitotoxicity and amyotrophic lateral sclerosis

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12 December 2020

Cloning of a putative glutamate receptor: a low affinity kainate-binding subunit

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12 December 2020

Corelease of two fast neurotransmitters at a central synapse.

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12 December 2020

Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis.

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12 December 2020

Differential regional distribution of AMPA receptor subunit messenger RNAs in the human spinal cord as visualized by in situ hybridization

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12 December 2020

Familial amyotrophic lateral sclerosis with a mutation in exon 4 of the Cu/Zn superoxide dismutase gene: pathological and immunocytochemical changes

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12 December 2020

Identification of a site in glutamate receptor subunits that controls calcium permeability

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12 December 2020

Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines

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12 December 2020

Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS

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12 December 2020

Calcium-binding proteins in the nervous system

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12 December 2020

Distribution of AMPA-selective glutamate receptor subunits in the human hippocampus and cerebellum

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12 December 2020

Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis

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12 December 2020

Calcium: still center-stage in hypoxic-ischemic neuronal death

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12 December 2020

Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit

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12 December 2020

Action of 5-hydroxytryptamine, substance P, thyrotropin-releasing hormone and clonidine on motoneurone excitability

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12 December 2020

Cloned glutamate receptors

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12 December 2020

Novel insertion in the KSP region of the neurofilament heavy gene in amyotrophic lateral sclerosis (ALS)

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12 December 2020

Cytochrome c oxidase subunit I microdeletion in a patient with motor neuron disease.

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12 December 2020

Glutamate potentiates the toxicity of mutant Cu/Zn-superoxide dismutase in motor neurons by postsynaptic calcium-dependent mechanisms

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12 December 2020

Identification of alternative splicing forms of GLT-1 mRNA in the spinal cord of amyotrophic lateral sclerosis patients.

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12 December 2020

Amyotrophic lateral sclerosis and its association with dementia, parkinsonism and other neurological disorders: a review

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12 December 2020

Quantitative and qualitative changes in AMPA receptor expression during spinal cord development.

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12 December 2020

Parvalbumin and calbindin D-28k in the human motor system and in motor neuron disease.

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12 December 2020

Localization of N-acetylaspartylglutamate-like immunoreactivity in selected areas of the rat brain.

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12 December 2020

In vitro kainate injury to large, SMI-32(+) spinal neurons is Ca2+ dependent.

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12 December 2020

Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis

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12 December 2020

Expression of glutamate receptor subunits in alpha-motoneurons.

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12 December 2020

Identifiers

DOI

10.1007/S004150050553

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29 July 2017

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PubMed ID

10795883