Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels (Q33906456)

29 July 2017

Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels (English)

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29 July 2017

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11

Hannelore Daniel

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29 July 2017

Christoph Dahlhoff

1

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29 July 2017

Stefanie Worsch

2

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29 July 2017

Manuela Sailer

3

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29 July 2017

Björn A Hummel

4

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29 July 2017

Jarlei Fiamoncini

5

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29 July 2017

Kirsten Uebel

6

1 reference

29 July 2017

Rima Obeid

7

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29 July 2017

Christian Scherling

8

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29 July 2017

Jürgen Geisel

9

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29 July 2017

Bernhard L Bader

10

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29 July 2017

20 May 2014

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29 July 2017

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3

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5

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29 July 2017

565-580

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describes a project that uses

29 July 2017

limma

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22 June 2022

https://europepmc.org/article/PMC/4099513

inferred from PubMed Central ID database lookup

cites work

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C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemia

5 July 2018

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Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas

5 July 2018

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Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC-1α by PRMT1 and SIRT1.

5 July 2018

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Alterations in hepatic one-carbon metabolism and related pathways following a high-fat dietary intervention

5 July 2018

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5 July 2018

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Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine

5 July 2018

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5 July 2018

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Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease

5 July 2018

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Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors

5 July 2018

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Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity.

5 July 2018

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Homocysteine metabolism and its relation to health and disease

5 July 2018

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Binding of S-methyl-5'-thioadenosine and S-adenosyl-L-methionine to protein MJ0100 triggers an open-to-closed conformational change in its CBS motif pair

5 July 2018

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Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice

5 July 2018

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Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha

5 July 2018

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Non-alcoholic steatohepatitis and animal models: understanding the human disease.

5 July 2018

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The epidemiology of nonalcoholic fatty liver disease: a global perspective

5 July 2018

1 reference

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Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD).

5 July 2018

1 reference

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Methionine metabolism and liver disease

5 July 2018

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Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice

5 July 2018

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Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet

5 July 2018

1 reference

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Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes

5 July 2018

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Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine

5 July 2018

1 reference

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Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation

5 July 2018

1 reference

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Methionine metabolism in mammals

5 July 2018

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Molecular mediators of hepatic steatosis and liver injury

5 July 2018

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Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper – Excel-based tool using pair-wise correlations

5 July 2018

1 reference

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AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome

5 July 2018

1 reference

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The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine

5 July 2018

1 reference

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Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice

5 July 2018

1 reference

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A gender-specific role for phosphatidylethanolamine N-methyltransferase-derived phosphatidylcholine in the regulation of plasma high density and very low density lipoproteins in mice

5 July 2018

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Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

5 July 2018

1 reference

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Neonatal hepatic steatosis by disruption of the adenosine kinase gene

5 July 2018

1 reference

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Nonalcoholic fatty liver disease

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

Carnitine biosynthesis in mammals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteine methyltransferase gene expression and organization of the human gene

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

Biochemical and evolutionary significance of phospholipid methylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: diagnosis by acylcarnitine analysis in blood.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

Simultaneous quantification of S-adenosyl methionine and S-adenosyl homocysteine in human plasma by stable-isotope dilution ultra performance liquid chromatography tandem mass spectrometry

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

Corresponding increase in long-chain acyl-CoA and acylcarnitine after exercise in muscle from VLCAD mice

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

Casitas b-lineage lymphoma-deficient mice are protected against high-fat diet-induced obesity and insulin resistance

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4099513

Dietary betaine modifies hepatic metabolism but not renal injury in rat polycystic kidney disease

29 October 2018

1 reference

12 December 2020

Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation

1 reference

12 December 2020

ACTIONS OF BETAINE, CARNITINE AND CHOLINE ON THE PATTERN OF HEPATIC LIPOSIS IN MICE FED A HIGH-FAT, LOW-PROTEIN DIET

1 reference

12 December 2020

Regulation of hepatic betaine-homocysteine methyltransferase by dietary betaine

1 reference

12 December 2020

Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats

1 reference

12 December 2020

Methyl donor deficiency impairs fatty acid oxidation through PGC-1α hypomethylation and decreased ER-α, ERR-α, and HNF-4α in the rat liver

1 reference

12 December 2020

S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase

1 reference

12 December 2020

10.1016/J.MOLMET.2014.04.010

Identifiers

DOI

1 reference

29 July 2017

1 reference

29 July 2017

1 reference