Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes (Q34737010)

4 August 2017

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title

Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes (English)

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4 August 2017

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Deborah M Muoio

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Christopher B Newgard

series ordinal

2

object named as

Christopher B Newgard

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4 August 2017

1 March 2008

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Nature Reviews Molecular Cell Biology

4 August 2017

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4 August 2017

9

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4 August 2017

193-205

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4 August 2017

3

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https://scigraph.springernature.com/pub.10.1038/nrm2327

4 August 2017

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Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling

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Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets

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31 March 2020

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31 March 2020

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Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease

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PKC-theta knockout mice are protected from fat-induced insulin resistance

31 March 2020

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31 March 2020

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Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

31 March 2020

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31 March 2020

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Hierarchy of the beta-cell signals controlling insulin secretion.

31 March 2020

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Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic beta-cells

31 March 2020

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Quantifying the carboxylation of pyruvate in pancreatic islets

31 March 2020

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Estimates of glycolysis, pyruvate (de)carboxylation, pentose phosphate pathway, and methyl succinate metabolism in incapacitated pancreatic islets

31 March 2020

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Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells

31 March 2020

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13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

31 March 2020

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Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue

31 March 2020

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13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells

31 March 2020

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Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion

31 March 2020

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The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion

31 March 2020

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A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion

31 March 2020

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Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion.

31 March 2020

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Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion

31 March 2020

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Mitochondrial GTP regulates glucose-stimulated insulin secretion

31 March 2020

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Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice

31 March 2020

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Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.

31 March 2020

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Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death

31 March 2020

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

31 March 2020

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Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci.

31 March 2020

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MONOGENIC DIABETES MELLITUS IN YOUTH

31 March 2020

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Regulatory effects of glucose on the catalytic activity and cellular content of glucokinase in the pancreatic beta cell. Study using cultured rat islets

31 March 2020

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Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose

31 March 2020

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Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes

31 March 2020

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Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle

31 March 2020

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Palmitate-induced beta-cell insensitivity to glucose is coupled to decreased pyruvate dehydrogenase activity and enhanced kinase activity in rat pancreatic islets

31 March 2020

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Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets

31 March 2020

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Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic beta-cell line INS-1.

31 March 2020

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beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats

31 March 2020

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Regulation of the uncoupling protein-2 gene in INS-1 beta-cells by oleic acid.

31 March 2020

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Free fatty acid-induced beta-cell defects are dependent on uncoupling protein 2 expression

31 March 2020

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Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

31 March 2020

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Uncoupling protein 2 and islet function

31 March 2020

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Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet

31 March 2020

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Evidence against the involvement of oxidative stress in fatty acid inhibition of insulin secretion

31 March 2020

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Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet beta cell

31 March 2020

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Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

31 March 2020

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Translational control is required for the unfolded protein response and in vivo glucose homeostasis

31 March 2020

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Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis

31 March 2020

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Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients

31 March 2020

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Beta-cell deficit due to increased apoptosis in the human islet amyloid polypeptide transgenic (HIP) rat recapitulates the metabolic defects present in type 2 diabetes.

31 March 2020

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Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane

31 March 2020

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Lipid phosphatases as drug discovery targets for type 2 diabetes.

31 March 2020

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Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.

31 March 2020

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Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance

31 March 2020

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The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

31 March 2020

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Neuronal pathway from the liver modulates energy expenditure and systemic insulin sensitivity

31 March 2020

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Molecular disruption of hypothalamic nutrient sensing induces obesity.

31 March 2020

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Regulation of blood glucose by hypothalamic pyruvate metabolism

31 March 2020

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Biology of incretins: GLP-1 and GIP

31 March 2020

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Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.

31 March 2020

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A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?

31 March 2020

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Interaction of ATP sensor, cAMP sensor, Ca2+ sensor, and voltage-dependent Ca2+ channel in insulin granule exocytosis

31 March 2020

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The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids

31 March 2020

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Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

31 March 2020

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The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse

31 March 2020

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GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo.

31 March 2020

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Impaired gene and protein expression of exocytotic soluble N-ethylmaleimide attachment protein receptor complex proteins in pancreatic islets of type 2 diabetic patients

31 March 2020

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Hepatotoxicity due to troglitazone: report of two cases and review of adverse events reported to the United States Food and Drug Administration

31 March 2020

1 reference

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

31 March 2020

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Drug treatment of the overweight patient

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM2327

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PubMed ID

18200017

Dimensions Publication ID

4 August 2017

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PubMed ID

18200017