Immunosuppressive drugs: the first 50 years and a glance forward (Q33908046)

29 July 2017

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title

Immunosuppressive drugs: the first 50 years and a glance forward (English)

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29 July 2017

A C Allison

1

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29 July 2017

1 May 2000

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29 July 2017

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29 July 2017

47

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29 July 2017

63-83

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29 July 2017

2-3

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Immunopharmacology of rapamycin

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Methotrexate use in rheumatoid arthritis. A Clinician's perspective

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Mycophenolate mofetil and its mechanisms of action

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Applications of tacrolimus for the treatment of skin disorders

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https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Inhaled glucocorticoids for asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Immunopharmacological profile of HWA 486, a novel isoxazol derivative--II. In vivo immunomodulating effects differ from those of cyclophosphamide, prednisolone, or cyclosporin A

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Effects of leflunomide on immune responses and models of inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

20-EPI-vitamin D3 analogues: A novel class of potent regulators of cell growth and immune responses

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Propriocidal apoptosis of mature T lymphocytes occurs at S phase of the cell cycle.

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

TGF-beta in kidney fibrosis: a target for gene therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Biological effects of cyclosporin A: A new antilymphocytic agent

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Hyperlipidemia in renal transplant recipients treated with sirolimus (rapamycin)

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Azathioprine alone is bone sparing and does not alter cyclosporin A-induced osteopenia in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Cholesterol control: long-term benefit of pancreas-kidney transplantation with FK 506 immunosuppression

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Effects of orally administered rapamycin in animal models of arthritis and other autoimmune diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Polyglutamation of methotrexate. Is methotrexate a prodrug?

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Azathioprine metabolism: pharmacokinetics of 6-mercaptopurine, 6-thiouric acid and 6-thioguanine nucleotides in renal transplant patients

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Mycophenolic acid increases apoptosis, lysosomes and lipid droplets in human lymphoid and monocytic cell lines

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https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Peritransplant tolerance induction with anti-CD3-immunotoxin: a matter of proinflammatory cytokine control.

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

The effect of a new immunosuppressive drug, brequinar sodium, on heart, liver, and kidney allograft rejection in the rat

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https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Cyclosporin in therapeutic doses increases renal allograft vascular resistance.

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Bone histomorphometry in glucocorticoid-induced osteoporosis

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https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Mycophenolate mofetil: a promising new immunosuppressant that does not cause bone loss in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

The purine path to chemotherapy

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Mycophenolic acid for psoriasis. A review of pharmacology, long-term efficacy, and safety

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Advances in chemotherapy of cancer in man

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

The inhibition of nucleic acid synthesis by mycophenolic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

The effect of aminomethylpteroylglutamic acid on the development of skin hypersensitivity and on antibody formation in guinea pigs

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Prevention of Atherosclerosis in Coronary-Artery Bypass Grafts

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Mechanisms of action of methotrexate.

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

The Biological Actions and Therapeutic Applications of the B-Chloroethyl Amines and Sulfides

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Sirolimus (rapamycin)-based therapy in human renal transplantation: similar efficacy and different toxicity compared with cyclosporine. Sirolimus European Renal Transplant Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Leflunomide: an immunomodulatory drug for the treatment of rheumatoid arthritis and other autoimmune diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Cyclosporine induces cancer progression by a cell-autonomous mechanism.

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Organospecific activation of azathioprine in mice: role of liver metabolism in mutation induction.

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Synthesis of (-)-15-deoxyspergualin and (-)-spergualin-15-phosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

In vitro study of BCX-34: a new human T-lymphocyte-specific purine phosphorylase inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Cellular basis of transplantation tolerance induced by liver grafting in the rat. Extent of clonal deletion among thoracic duct lymphocytes, spleen, and lymph node cells

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

The functional relevance of passenger leukocytes and microchimerism for heart allograft acceptance in the rat

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

The pharmacology of T cell apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Differential regulation of transforming growth factor beta and interleukin 2 genes in human T cells: demonstration by usage of novel competitor DNA constructs in the quantitative polymerase chain reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Inhibition of the immune response by rapamycin, a new antifungal antibiotic

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

The transforming growth factor-beta family

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

A BLINDED, LONG-TERM, RANDOMIZED MULTICENTER STUDY OF MYCOPHENOLATE MOFETIL IN CADAVERIC RENAL TRANSPLANTATION

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Mechanisms of action of cyclosporine.

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Apoptosis of alloreactive T cells in liver allografts during tolerance induction

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Prolonged survival of human-kidney homografts by immunosuppressive drug therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Decrease of apoptosis rate in patients with renal transplantation treated with mycophenolate mofetil

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Cyclophosphamide-sensitive T lymphocytes suppress the in vivo generation of antigen-specific cytotoxic T lymphocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

EFFECTS OF SELECTED CYTOTOXIC AGENTS ON ANTIBODY PRODUCTION IN MAN; A PRELIMARY REPORT

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Drug-induced Immunological Tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

The effects of 6-mercaptopurine on homograft reactions

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Rapamycin (AY-22,989), a new antifungal antibiotic. II. Fermentation, isolation and characterization.

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Evidence that apoptosis of activated T cells occurs in spontaneous tolerance of liver allografts and is blocked by manipulations which break tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

The structure of inosine 5'-monophosphate dehydrogenase and the design of novel inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Tolerance to rat liver allografts: IV. Acceptance depends on the quantity of donor tissue and on donor leukocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Chimerism and central tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

A new antitumor antibiotic, spergualin: isolation and antitumor activity

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

STUDIES ON THE MECHANISM OF ACTION OF METHOTREXATE AND CYCLOPHOSPHAMIDE ON CONTACT SENSITIVITY IN THE GUINEA PIG

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Homeostasis and self-tolerance in the immune system: turning lymphocytes off.

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

The use of leflunomide in transplantation immunology

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance.

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Induction of apoptosis in mature T cells by tumour necrosis factor

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

Orthotopic liver allografts in the rat. The influence of strain combination on the fate of the graft

1 reference

https://api.crossref.org/works/10.1016%2FS0162-3109%2800%2900186-7

7 January 2021

10.1016/S0162-3109(00)00186-7

Identifiers

DOI

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29 July 2017

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PubMed ID

10878284