Polyglutamation of methotrexate. Is methotrexate a prodrug? (Q34552178)

3 August 2017

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title

Polyglutamation of methotrexate. Is methotrexate a prodrug? (English)

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3 August 2017

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Chabner BA

1

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3 August 2017

Allegra CJ

2

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3 August 2017

Curt GA

3

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3 August 2017

Clendeninn NJ

4

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3 August 2017

Baram J

5

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3 August 2017

Koizumi S

6

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3 August 2017

Drake JC

7

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3 August 2017

Jolivet J

8

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3 August 2017

language of work or name

English

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publication date

1 September 1985

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Journal of Clinical Investigation

3 August 2017

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3 August 2017

76

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3 August 2017

3

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3 August 2017

907-912

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DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

3 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423952

Enzymatic synthesis of folylpolyglutamates. Characterization of the reaction and its products

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423952

Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423952

Folylpoly-gamma-glutamate synthesis by bacteria and mammalian cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423952

Gene amplification in cultured animal cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423952

A methotrexate-resistant human breast cancer cell line with multiple defects, including diminished formation of methotrexate polyglutamates

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423952

Development of methotrexate resistance in a human squamous cell carcinoma of the head and neck in culture

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423952

Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423952

Synthesis, Retention, and Biological Activity of Methotrexate Polyglutamates in Cultured Human Breast Cancer Cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423952

Methotrexate polyglutamate synthesis by cultured human breast cancer cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423952

Threshold Methotrexate Concentration for In Vivo Inhibition of DNA Synthesis in Normal and Tumorous Target Tissues

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423952

Polygammaglutamyl metabolites of methotrexate.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423952

Formation of methotrexate polyglutamates in purified myeloid precursor cells from normal human bone marrow

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423952

Tissue-specific synthesis of methotrexate polyglutamates in the rat

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423952

Accumulation of methotrexate diglutamate in human liver during methotrexate therapy

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=423952

Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro

7 July 2018

1 reference

12 December 2020

Analysis of the role of membrane transport and polyglutamation of methotrexate in gut and the Ehrlich tumor in vivo as factors in drug sensitivity and selectivity

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12 December 2020

Synthesis and retention of methotrexate polyglutamates by human small cell lung cancer

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12 December 2020

Polyglutamylation, an important element in methotrexate cytotoxicity and selectivity in tumor versus murine granulocytic progenitor cells in vitro

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12 December 2020

Folylpolyglutamate synthetase from beef liver: assay, stabilization, and characterization

1 reference

12 December 2020

Carrier-mediated Transport of the Folic Acid Analogue, Methotrexate, in the L1210 Leukemia Cell

1 reference

12 December 2020

Stoichiometric inhibition of mammalian dihydrofolate reductase by the γ-glutamyl metabolite of methotrexate, 4-amino-4-deoxy-N10-methylpteroylglutamyl-γ-glutamate

1 reference

12 December 2020

The mechanism of action of methotrexate. III. Requirement of free intracellular methotrexate for maximal suppression of (14C)formate incorporation into nucleic acids and protein

1 reference

12 December 2020

The reversal of methotrexate cytotoxicity to mouse bone marrow cells by leucovorin and nucleosides

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12 December 2020

Synthesis of methotrexate polyglutamates in cultured human cells

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12 December 2020

Human thymidylate synthetase--III. Effects of methotrexate and folate analogs

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12 December 2020

Pteroylpoly(gamma-glutamate) synthesis by Corynebacterium species. Purification and properties of folypoly(gamma-glutamate) synthetase

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12 December 2020

Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate

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12 December 2020

Identifiers

DOI

10.1172/JCI112088

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3 August 2017

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3 August 2017

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