The role of hypoxia inducible factor-1 in hepatocellular carcinoma (Q33914603)

30 July 2017

1 reference

22 December 2020

The role of hypoxia inducible factor-1 in hepatocellular carcinoma (English)

1 reference

25101278

hypoxia-inducible factor 1

30 July 2017

main subject

hepatocellular carcinoma

1 reference

18 September 2020

1 reference

18 September 2020

1 reference

1 December 2020

1 reference

22 December 2020

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25101278%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

author name string

Dongjun Luo

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25101278%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Zhongxia Wang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25101278%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Junyi Wu

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25101278%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Chunping Jiang

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25101278%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

language of work or name

English

0 references

publication date

2 July 2014

7 references

BioMed Research International

30 July 2017

3 April 2019

30 June 2019

11 December 2019

22 December 2019

1 December 2020

22 December 2020

7 references

3 April 2019

30 June 2019

11 December 2019

22 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25101278%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 December 2020

22 December 2020

2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25101278%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

page(s)

409272

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25101278%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 3.0 Unported

1 June 2020

copyright license

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3 April 2019

30 June 2019

11 December 2019

22 December 2019

18 September 2020

1 December 2020

on focus list of Wikimedia project

22 December 2020

copyright status

copyrighted

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ScienceSource

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Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma.

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Effects of the knockdown of hypoxia inducible factor-1α expression by adenovirus-mediated shRNA on angiogenesis and tumor growth in hepatocellular carcinoma cell lines.

5 July 2018

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Hypoxia-inducible factor 1, hepatocellular carcinoma and angiogenesis

5 July 2018

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Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production.

5 July 2018

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HIF-1alpha: a valid therapeutic target for tumor therapy

5 July 2018

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Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling

5 July 2018

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Hypoxia-inducible factor-1alpha mediates oral squamous cell carcinoma invasion via upregulation of alpha5 integrin and fibronectin

5 July 2018

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Expression of hypoxia-inducible factor-1alpha in liver tumors after transcatheter arterial embolization in an animal model

5 July 2018

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Hypoxia-inducible factor-1 alpha, in association with inflammation, angiogenesis and MYC, is a critical prognostic factor in patients with HCC after surgery

5 July 2018

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HIF-1: upstream and downstream of cancer metabolism

5 July 2018

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Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

5 July 2018

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Regulation of cancer cell metabolism by hypoxia-inducible factor 1.

5 July 2018

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5 July 2018

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Antisense hypoxia-inducible factor 1alpha gene therapy enhances the therapeutic efficacy of doxorubicin to combat hepatocellular carcinoma

5 July 2018

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The angiopoietin-2 gene of endothelial cells is up-regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA-2 and Ets-1.

5 July 2018

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Direct regulation of TWIST by HIF-1alpha promotes metastasis

5 July 2018

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Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

5 July 2018

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Inhibitory effect of hypoxia inducible factor-1 antisense oligonucleotide on growth of human hepatocellular carcinoma cells

5 July 2018

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SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia

5 July 2018

1 reference

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RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

Preclinical evaluation of YC-1, a HIF inhibitor, for the prevention of tumor spreading

5 July 2018

1 reference

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HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

5 July 2018

1 reference

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The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism.

5 July 2018

1 reference

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Proline hydroxylation and gene expression

5 July 2018

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Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis

5 July 2018

1 reference

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Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

5 July 2018

1 reference

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HIF-1alpha induces cell cycle arrest by functionally counteracting Myc.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

5 July 2018

1 reference

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Hypoxia Attenuates the Expression of E-Cadherin via Up-Regulation of SNAIL in Ovarian Carcinoma Cells

5 July 2018

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HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

5 July 2018

1 reference

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Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene

5 July 2018

1 reference

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Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

Hypoxia-inducible factor 1 transactivates the human leptin gene promoter

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene.

5 July 2018

1 reference

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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

Regulation of endothelial matrix metalloproteinase-2 by hypoxia/reoxygenation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

Expression of genes encoding type IV collagen-degrading metalloproteinases and tissue inhibitors of metalloproteinases in various human tumor cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

Sumoylation increases HIF-1alpha stability and its transcriptional activity

5 July 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F409272

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F409272

Nuclear translocation of hypoxia-inducible factors (HIFs): involvement of the classical importin alpha/beta pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F409272

Cardiac myocyte-specific HIF-1alpha deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart

21 January 2018

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https://api.crossref.org/works/10.1155%2F2014%2F409272

Hypoxia, HIF1 and glucose metabolism in the solid tumour

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F409272

Glucose catabolism in cancer cells: identification and characterization of a marked activation response of the type II hexokinase gene to hypoxic conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F409272

Hypoxia induces apoptosis and autophagic cell death in human periodontal ligament cells through HIF-1α pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F409272

Hypoxia-inducible factor-1alpha suppressed hepatocellular carcinoma cell apoptosis through influencing on Omi/HtrA2 expression and its releasing from the mitochondrion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F409272

Sulforaphane induces apoptosis in human hepatic cancer cells through inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4, mediated by hypoxia inducible factor-1-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F409272

Expression and correlation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor and microvessel density in experimental rat hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F409272

Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F409272

Synapse loss regulated by matrix metalloproteinases in traumatic brain injury is associated with hypoxia inducible factor-1alpha expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F409272

Gene expression profiling of fixed tissues identified hypoxia-inducible factor-1α, VEGF, and matrix metalloproteinase-2 as biomarkers of lymph node metastasis in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F409272

Correlation of hypoxia-inducible factor 1alpha with angiogenesis in liver tumors after transcatheter arterial embolization in an animal model

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F409272

Experimental evaluation of inhibitory effect of 10-hydroxycamptothecin on hypoxia-inducible factor-1α expression and angiogenesis in liver tumors after transcatheter arterial embolization

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F409272

Hypoxic Regulation of Lactate Dehydrogenase A

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2014%2F409272

Effect of environmental factors on chemoresistance of HepG2 cells by regulating hypoxia-inducible factor-1α.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

Silencing hypoxia-inducible factor-1alpha inhibits cell migration and invasion under hypoxic environment in malignant gliomas.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4101982

Induction ofID2Expression by Hypoxia-inducible Factor-1

29 October 2018

1 reference

12 December 2020

Normoxically overexpressed hypoxia inducible factor 1-alpha is involved in arsenic trioxide resistance acquisition in hepatocellular carcinoma

1 reference

12 December 2020

[Hypoxia in hepatocellular carcinoma]

1 reference

12 December 2020

[The prognostic significance of Omi/HtrA2 expression, and correlation between Omi/HtrA2 and hypoxia-inducible factor-1α in primary hepatocellular carcinoma cells]

1 reference

12 December 2020

The expression of HIF-1α in primary hepatocellular carcinoma and its correlation with radiotherapy response and clinical outcome

1 reference

12 December 2020

Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer

1 reference

12 December 2020

Hypoxia in abdominal aortic aneurysm supports a role for HIF-1α and Ets-1 as drivers of matrix metalloproteinase upregulation in human aortic smooth muscle cells

1 reference

12 December 2020

Deregulation of HIF1-alpha and hypoxia-regulated pathways in hepatocellular carcinoma and corresponding non-malignant liver tissue--influence of a modulated host stroma on the prognosis of HCC

1 reference

12 December 2020

Identifiers

DOI

10.1155/2014/409272

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25101278%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25101278%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

25101278

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25101278%20AND%20SRC:MED&resulttype=core&format=json