HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity (Q40136909)

17 September 2017

HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity (English)

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17 September 2017

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8

Gregg L Semenza

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17 September 2017

Huafeng Zhang

1

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17 September 2017

Ping Gao

2

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17 September 2017

Ryo Fukuda

3

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17 September 2017

Ganesh Kumar

4

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17 September 2017

Balaji Krishnamachary

5

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17 September 2017

Karen I Zeller

6

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17 September 2017

Chi V Dang

7

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17 September 2017

1 May 2007

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17 September 2017

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17 September 2017

11

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17 September 2017

407-420

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17 September 2017

5

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

17 September 2017

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/20459

HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Targeting HIF-1 for cancer therapy

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

c-Myc transactivation of LDH-A: implications for tumor metabolism and growth

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

p53 stabilization and transactivation by a von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Up-regulation of hypoxia-inducible factors HIF-1alpha and HIF-2alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Mechanism of HIF-1alpha-dependent suppression of hypoxia-induced apoptosis in squamous cell carcinoma cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Prognostic factors for survival of patients with stage IV renal cell carcinoma: memorial sloan-kettering cancer center experience.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Why do cancers have high aerobic glycolysis?

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

p53 regulates mitochondrial respiration

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Akt stimulates aerobic glycolysis in cancer cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Myc versus USF: discrimination at the cad gene is determined by core promoter elements

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Expression of hypoxia-inducible factor 1? in brain tumors

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Antagonistic effects of c-myc and Epstein-Barr virus latent genes on the phenotype of human B cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Transcriptional regulatory circuits controlling mitochondrial biogenesis and function

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Hypoxia regulates beta-enolase and pyruvate kinase-M promoters by modulating Sp1/Sp3 binding to a conserved GC element

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Somatic mutations of the mitochondrial genome in human colorectal tumours

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Inhibiting hypoxia-inducible factor 1 for cancer therapy

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Hypoxic Regulation of Lactate Dehydrogenase A

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Functional analysis of the N-terminal domain of the Myc oncoprotein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Efficient execution of cell death in non-glycolytic cells requires the generation of ROS controlled by the activity of mitochondrial H+-ATP synthase

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Role of oxidative stress in intermittent hypoxia-induced immediate early gene activation in rat PC12 cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Global mapping of c-Myc binding sites and target gene networks in human B cells

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Mxi1 is induced by hypoxia in a HIF-1-dependent manner and protects cells from c-Myc-induced apoptosis.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Proteomic identification of a role for the von Hippel Lindau tumour suppressor in changes in the expression of mitochondrial proteins and septin 2 in renal cell carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

mtDNA mutations increase tumorigenicity in prostate cancer

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

A new role for the von Hippel-Lindau tumor suppressor protein: stimulation of mitochondrial oxidative phosphorylation complex biogenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Regulation of E-cadherin expression by VHL and hypoxia-inducible factor.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Reversion of transformed glycolysis to normal by inhibition of protein synthesis in rat kidney cells infected with temperature-sensitive mutant of Rous sarcoma virus

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Proteomic changes in renal cancer and co-ordinate demonstration of both the glycolytic and mitochondrial aspects of the Warburg effect

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

The bioenergetic signature of lung adenocarcinomas is a molecular marker of cancer diagnosis and prognosis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Mitochondrial disorders in renal tumors.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Hypoxia-inducible factor-1alpha and the glycolytic phenotype in tumors.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2007.04.001

Identifiers

DOI

10.1016/J.CCR.2007.04.001

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17 September 2017

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