Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance. (Q33920767)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24905005%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

title

Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance (English)

1 reference

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20 March 2020

1 reference

1 reference

1 reference

1

1 reference

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20 March 2020

Hsing-Chen Tsai

series ordinal

2

1 reference

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20 March 2020

3

Stephen B Baylin

1 reference

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20 March 2020

publication date

1 June 2014

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20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24905005%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

volume

54

1 reference

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20 March 2020

issue

5

1 reference

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20 March 2020

page(s)

716-727

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20 March 2020

1 reference

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The epigenetics of epithelial-mesenchymal plasticity in cancer

5 July 2018

1 reference

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Transcriptional regulation by Polycomb group proteins

5 July 2018

1 reference

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Efficient induction of differentiation and growth inhibition in IDH1 mutant glioma cells by the DNMT Inhibitor Decitabine.

5 July 2018

1 reference

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5-azacytidine reduces methylation, promotes differentiation and induces tumor regression in a patient-derived IDH1 mutant glioma xenograft.

5 July 2018

1 reference

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Induction of sarcomas by mutant IDH2

5 July 2018

1 reference

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Tumour heterogeneity and cancer cell plasticity

5 July 2018

1 reference

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Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities

5 July 2018

1 reference

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The future of epigenetic therapy in solid tumours--lessons from the past.

5 July 2018

1 reference

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Interplay between the cancer genome and epigenome

5 July 2018

1 reference

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Lessons from the cancer genome

5 July 2018

1 reference

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5 July 2018

Cancer genome landscapes

1 reference

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Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

The epigenome of AML stem and progenitor cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Cell plasticity and heterogeneity in cancer.

5 July 2018

1 reference

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Asymmetrically modified nucleosomes

5 July 2018

1 reference

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An integrated encyclopedia of DNA elements in the human genome

5 July 2018

1 reference

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Cancer genetics and epigenetics: two sides of the same coin?

5 July 2018

1 reference

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Cancer epigenetics: from mechanism to therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

DNA methylation screening identifies driver epigenetic events of cancer cell survival

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Combination epigenetic therapy has efficacy in patients with refractory advanced non-small cell lung cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

A DNA hypermethylation module for the stem/progenitor cell signature of cancer.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

IDH mutation impairs histone demethylation and results in a block to cell differentiation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Polycomb associates genome-wide with a specific RNA polymerase II variant, and regulates metabolic genes in ESCs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Clonal evolution in cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Intragenic DNA methylation: implications of this epigenetic mechanism for cancer research

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

A decade of exploring the cancer epigenome - biological and translational implications

5 July 2018

1 reference

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Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Increased methylation variation in epigenetic domains across cancer types

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Generation of bivalent chromatin domains during cell fate decisions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Regulating RNA polymerase pausing and transcription elongation in embryonic stem cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Breast cancer methylomes establish an epigenomic foundation for metastasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Tumour evolution inferred by single-cell sequencing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

5 July 2018

1 reference

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Distant metastasis occurs late during the genetic evolution of pancreatic cancer

5 July 2018

1 reference

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Nucleosome dynamics and epigenetic stability.

5 July 2018

1 reference

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Conserved role of intragenic DNA methylation in regulating alternative promoters

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth

5 July 2018

1 reference

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Epigenomic alterations and gene expression profiles in respiratory epithelia exposed to cigarette smoke condensate.

5 July 2018

1 reference

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Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

5 July 2018

1 reference

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Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy

5 July 2018

1 reference

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A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

5 July 2018

1 reference

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Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC.

5 July 2018

1 reference

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Epithelial-mesenchymal transitions in development and disease

5 July 2018

1 reference

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Evidence for field cancerization of the prostate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Alterations of histone modifications by cobalt compounds

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

IDH1 and IDH2 mutations in gliomas

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Methylation of polycomb target genes in intestinal cancer is mediated by inflammation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Epigenomics and breast cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Genomic analysis of the clonal origins of relapsed acute lymphoblastic leukemia.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Abnormal DNA methylation of CD133 in colorectal and glioblastoma tumors

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Chemical probes for histone-modifying enzymes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

An integrated genomic analysis of human glioblastoma multiforme

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Resistance mechanisms to cancer chemotherapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Comparative lesion sequencing provides insights into tumor evolution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Identification of higher-order functional domains in the human ENCODE regions

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Perceptions of epigenetics

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

On the use of the word 'epigenetic'.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Epigenetic field for cancerization

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Epigenetic stem cell signature in cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Chromatin signatures of pluripotent cell lines

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Epigenetic alterations in RASSF1A in human aberrant crypt foci

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

MGMT promoter methylation and field defect in sporadic colorectal cancer.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Investigating stem cells in human colon by using methylation patterns

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

CpG island methylator phenotype in colorectal cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

DNA methylation: evolution of a bacterial immune function into a regulator of gene expression and genome structure in higher eukaryotes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Mutation selection and the natural history of cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

The clonal evolution of tumor cell populations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Unravelling cancer stem cell potential.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

An aberrant transcription factor network essential for Wnt signaling and stem cell maintenance in glioblastoma.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

29 October 2018

The epigenotype. 1942.

1 reference

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Intratumoral heterogeneity determines discordant results of diagnostic tests for human epidermal growth factor receptor (HER) 2 in gastric cancer specimens.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Genetic variegation of clonal architecture and propagating cells in leukaemia

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Induction of epigenetic alterations by chronic inflammation and its significance on carcinogenesis.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Quantitative, spatial resolution of the epigenetic field effect in prostate cancer

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Swapping function of two chromatin remodeling complexes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4103691

Cancer stem cells: an evolving concept

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24905005

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Promoter hypermethylation of hallmark cancer genes in atypical adenomatous hyperplasia of the lung

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24905005

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Aging and DNA methylation in colorectal mucosa and cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24905005

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.MOLCEL.2014.05.015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24905005%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24905005%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

PubMed publication ID

24905005

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24905005%20AND%20SRC:MED&resulttype=core&format=json