BET Inhibitor JQ1 Blocks Inflammation and Bone Destruction. (Q33936571)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24799421%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

title

BET Inhibitor JQ1 Blocks Inflammation and Bone Destruction (English)

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17 March 2020

9

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17 March 2020

author name string

S Meng

1

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17 March 2020

L Zhang

2

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17 March 2020

Y Tang

3

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17 March 2020

Q Tu

4

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17 March 2020

L Zheng

5

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17 March 2020

L Yu

6

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17 March 2020

D Murray

7

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17 March 2020

J Cheng

8

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17 March 2020

X Zhou

10

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17 March 2020

J Chen

11

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17 March 2020

language of work or name

English

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publication date

5 May 2014

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Journal of Dental Research

17 March 2020

published in

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17 March 2020

volume

93

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17 March 2020

issue

7

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17 March 2020

page(s)

657-662

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Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.

17 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107547

Regulation of NO synthesis, local inflammation, and innate immunity to pathogens by BET family proteins

5 July 2018

1 reference

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Assessment of Brd4 inhibition in idiopathic pulmonary fibrosis lung fibroblasts and in vivo models of lung fibrosis

5 July 2018

1 reference

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BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses.

5 July 2018

1 reference

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Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells

5 July 2018

1 reference

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Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

5 July 2018

1 reference

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BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia

5 July 2018

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Small-molecule inhibition of BRDT for male contraception

5 July 2018

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Targeting epigenetic readers in cancer.

5 July 2018

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Down-regulation of NF-κB transcriptional activity in HIV-associated kidney disease by BRD4 inhibition

5 July 2018

1 reference

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Place your BETs: the therapeutic potential of bromodomains

5 July 2018

1 reference

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Regulation of primary response genes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107547

Targeting MYC dependence in cancer by inhibiting BET bromodomains

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107547

Bromodomains as therapeutic targets

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107547

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

5 July 2018

1 reference

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

5 July 2018

1 reference

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Suppression of inflammation by a synthetic histone mimic

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107547

Selective inhibition of BET bromodomains

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107547

Periodontitis: a polymicrobial disruption of host homeostasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107547

Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107547

Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107547

Control of inducible gene expression by signal-dependent transcriptional elongation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107547

Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107547

The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107547

Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107547

Control of inflammation and periodontitis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107547

The double bromodomain-containing chromatin adaptor Brd4 and transcriptional regulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107547

The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4107547

5 July 2018

Identifiers

DOI

10.1177/0022034514534261

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24799421%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

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17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24799421%20AND%20SRC:MED&resulttype=core&format=json