Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases (Q37621248)

21 August 2017

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title

Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases (English)

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21 August 2017

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Manolis Pasparakis

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publication date

1 November 2009

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Nature Reviews Immunology

21 August 2017

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21 August 2017

9

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21 August 2017

11

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21 August 2017

778-788

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Regulation and function of NF-kappaB transcription factors in the immune system

21 August 2017

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New regulators of NF-kappaB in inflammation

31 March 2020

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IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK

31 March 2020

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IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

31 March 2020

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The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation

31 March 2020

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A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB

31 March 2020

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Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

31 March 2020

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IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex

31 March 2020

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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

31 March 2020

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RelB/p50 Dimers Are Differentially Regulated by Tumor Necrosis Factor-α and Lymphotoxin-β Receptor Activation

31 March 2020

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Lymphotoxin beta receptor induces sequential activation of distinct NF-kappa B factors via separate signaling pathways

31 March 2020

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Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti

31 March 2020

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NEMO/IKK gamma-deficient mice model incontinentia pigmenti.

31 March 2020

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Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

31 March 2020

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The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

31 March 2020

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Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

31 March 2020

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IKK1 and IKK2 cooperate to maintain bile duct integrity in the liver

31 March 2020

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NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control

31 March 2020

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

31 March 2020

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Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

31 March 2020

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Suppression of TNF-alpha-induced apoptosis by NF-kappaB

31 March 2020

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TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

31 March 2020

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NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling

31 March 2020

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NF-kappaB signals induce the expression of c-FLIP.

31 March 2020

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NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

31 March 2020

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Nuclear factor (NF)-kappaB-regulated X-chromosome-linked iap gene expression protects endothelial cells from tumor necrosis factor alpha-induced apoptosis.

31 March 2020

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NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

31 March 2020

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Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species

31 March 2020

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Dissection of the NF-kappaB signalling cascade in transgenic and knockout mice.

31 March 2020

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Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B

31 March 2020

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Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice

31 March 2020

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IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice

31 March 2020

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Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

31 March 2020

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Crosstalk between Keratinocytes and Adaptive Immune Cells in an IκBα Protein-Mediated Inflammatory Disease of the Skin

31 March 2020

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IKKbeta/NF-kappaB activation causes severe muscle wasting in mice

31 March 2020

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IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer

31 March 2020

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Allergen-induced peribronchial fibrosis and mucus production mediated by IkappaB kinase beta-dependent genes in airway epithelium

31 March 2020

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Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy

31 March 2020

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IKK-beta links inflammation to obesity-induced insulin resistance

31 March 2020

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Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

31 March 2020

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Psoriasis: the epidermal component

31 March 2020

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TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2

31 March 2020

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Pathogenic role for skin macrophages in a mouse model of keratinocyte-induced psoriasis-like skin inflammation

31 March 2020

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Essential function for the kinase TAK1 in innate and adaptive immune responses.

31 March 2020

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

31 March 2020

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The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

31 March 2020

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TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis

31 March 2020

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TAK1 regulates reactive oxygen species and cell death in keratinocytes, which is essential for skin integrity

31 March 2020

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Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by NF-kappaB inhibition

31 March 2020

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Alterations in NF-kappaB function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-kappaB.

31 March 2020

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The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms.

31 March 2020

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Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium

31 March 2020

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Incontinentia pigmenti: a review and update on the molecular basis of pathophysiology.

31 March 2020

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Skin lesion development in a mouse model of incontinentia pigmenti is triggered by NEMO deficiency in epidermal keratinocytes and requires TNF signaling.

31 March 2020

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Localized inflammatory skin disease following inducible ablation of I kappa B kinase 2 in murine epidermis

31 March 2020

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Timed NF-kappaB inhibition in skin reveals dual independent effects on development of HED/EDA and chronic inflammation

31 March 2020

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The two-faced NF-kappaB in the skin.

31 March 2020

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Epidermal sensing of oxygen is essential for systemic hypoxic response

31 March 2020

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Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

31 March 2020

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NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha

31 March 2020

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c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin

31 March 2020

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Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial

31 March 2020

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Tumor necrosis factor antagonists in the therapy of psoriasis

31 March 2020

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The fundamental basis of inflammatory bowel disease

31 March 2020

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Activation of nuclear factor kappa B in Crohn's disease

31 March 2020

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Activation of nuclear factor kappa B inflammatory bowel disease

31 March 2020

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Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice

31 March 2020

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Amelioration of chronic murine colitis by peptide-mediated transduction of the IkappaB kinase inhibitor NEMO binding domain peptide

31 March 2020

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Cutting edge: The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks inflammatory injury in murine colitis

31 March 2020

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Epithelial NEMO links innate immunity to chronic intestinal inflammation

31 March 2020

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Mechanisms of disease: defensins in gastrointestinal diseases

31 March 2020

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A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon

31 March 2020

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Challenges in the use of allogeneic hematopoietic SCT for ectodermal dysplasia with immune deficiency.

31 March 2020

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Allogeneic transplantation successfully corrects immune defects, but not susceptibility to colitis, in a patient with nuclear factor-kappaB essential modulator deficiency

31 March 2020

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Signaling to NF-kappaB by Toll-like receptors

31 March 2020

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Unresponsiveness of MyD88-deficient mice to endotoxin

31 March 2020

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Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function

31 March 2020

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Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells

31 March 2020

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Role of toll-like receptors in spontaneous commensal-dependent colitis

31 March 2020

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Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis

31 March 2020

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MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis

31 March 2020

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Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function

31 March 2020

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Intestinal epithelial TOLLerance versus inTOLLerance of commensals

31 March 2020

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A critical role for TLR4 in the pathogenesis of necrotizing enterocolitis by modulating intestinal injury and repair.

31 March 2020

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Antitumor necrosis factor therapy for inflammatory bowel disease: a review of agents, pharmacology, clinical results, and safety

31 March 2020

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New therapeutic strategies for treatment of inflammatory bowel disease

31 March 2020

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Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases

31 March 2020

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Enterocyte-derived TAK1 signaling prevents epithelium apoptosis and the development of ileitis and colitis

31 March 2020

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Intestinal epithelial-derived TAK1 signaling is essential for cytoprotection against chemical-induced colitis

31 March 2020

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Gastrointestinal microbiology enters the metagenomics era.

31 March 2020

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Diversity of the human intestinal microbial flora

31 March 2020

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The commensal microbiology of the gastrointestinal tract

31 March 2020

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Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation

31 March 2020

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Opposing functions of IKKbeta during acute and chronic intestinal inflammation

31 March 2020

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IkappaB-kinasebeta-dependent NF-kappaB activation provides radioprotection to the intestinal epithelium

31 March 2020

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The two faces of IKK and NF-κB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion

31 March 2020

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Epithelial-cell-intrinsic IKK-β expression regulates intestinal immune homeostasis

31 March 2020

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Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB

31 March 2020

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TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation

31 March 2020

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Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality

31 March 2020

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Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment

31 March 2020

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Deletion of NEMO/IKKγ in Liver Parenchymal Cells Causes Steatohepatitis and Hepatocellular Carcinoma

31 March 2020

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IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

31 March 2020

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Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury

31 March 2020

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Genetic inactivation of RelA/p65 sensitizes adult mouse hepatocytes to TNF-induced apoptosis in vivo and in vitro.

31 March 2020

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Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy

31 March 2020

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Death receptor signal transducers: nodes of coordination in immune signaling networks

31 March 2020

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High susceptibility to bacterial infection, but no liver dysfunction, in mice compromised for hepatocyte NF-kappaB activation

31 March 2020

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IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

31 March 2020

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IKK mediates ischemia-induced neuronal death

31 March 2020

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Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice

31 March 2020

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Targeted ablation of IKK2 improves skeletal muscle strength, maintains mass, and promotes regeneration

31 March 2020

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Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo

31 March 2020

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Nuclear factor-{kappa}B activity in {beta}-cells is required for glucose-stimulated insulin secretion.

31 March 2020

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Deletion of TLR5 results in spontaneous colitis in mice

31 March 2020

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12 December 2020

Squamous cell carcinomas and increased apoptosis in skin with inhibited Rel/nuclear factor-kappaB signaling

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12 December 2020

Induction of Bcl-x(L) expression by human T-cell leukemia virus type 1 Tax through NF-kappaB in apoptosis-resistant T-cell transfectants with Tax.

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12 December 2020

Complete lack of NF-kappaB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation

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12 December 2020

Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance

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12 December 2020

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice

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12 December 2020

Identifiers

DOI

10.1038/NRI2655

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21 August 2017

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PubMed ID

19855404