Development of second generation EP2 antagonists with high selectivity (Q33939410)

24937185

30 July 2017

title

Development of second generation EP2 antagonists with high selectivity (English)

1 reference

30 July 2017

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24937185%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Raymond Dingledine

series ordinal

3

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8 June 2020

1

Thota Ganesh

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24937185%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

publication date

3 June 2014

1 reference

24937185

European Journal of Medicinal Chemistry

30 July 2017

published in

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8 June 2020

volume

82

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8 June 2020

page(s)

521-535

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Lead optimization studies of cinnamic amide EP2 antagonists

8 June 2020

cites work

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5 July 2018

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Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection

5 July 2018

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EP2 receptor signaling pathways regulate classical activation of microglia.

5 July 2018

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Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation

5 July 2018

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Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation.

5 July 2018

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Subclinical increased anterior stromal reflectivity with topical taprenepag isopropyl

5 July 2018

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Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2.

5 July 2018

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Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus

5 July 2018

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A phase 2, randomized, dose-response trial of taprenepag isopropyl (PF-04217329) versus latanoprost 0.005% in open-angle glaucoma and ocular hypertension

5 July 2018

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In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP₂ receptor antagonist

5 July 2018

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Effect of PF-04217329 a prodrug of a selective prostaglandin EP(2) agonist on intraocular pressure in preclinical models of glaucoma

5 July 2018

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Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor.

5 July 2018

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The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis

5 July 2018

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EP2 prostanoid receptor promotes squamous cell carcinoma growth through epidermal growth factor receptor transactivation and iNOS and ERK1/2 pathways

5 July 2018

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Prostaglandin E2 receptor subtype 2 (EP2) regulates microglial activation and associated neurotoxicity induced by aggregated alpha-synuclein

5 July 2018

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Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis

5 July 2018

1 reference

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Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities

5 July 2018

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Drug-protein adducts: an industry perspective on minimizing the potential for drug bioactivation in drug discovery and development

5 July 2018

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EP2 and EP4 prostanoid receptor signaling

5 July 2018

1 reference

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Prostanoid receptors: subtypes and signaling

5 July 2018

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A high-throughput screening method for the determination of aqueous drug solubility using laser nephelometry in microtiter plates

5 July 2018

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Prostanoid receptors: structures, properties, and functions

5 July 2018

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5 July 2018

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Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP(2)

29 October 2018

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5 July 2018

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EP2, a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival

29 October 2018

1 reference

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Overexpression of the prostaglandin E2 receptor EP2 results in enhanced skin tumor development.

29 October 2018

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Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease.

29 October 2018

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COX-2-derived prostacyclin confers atheroprotection on female mice

29 October 2018

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Neuroprotective function of the PGE2 EP2 receptor in cerebral ischemia.

29 October 2018

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Hepatic microsomal metabolism of indole to indoxyl, a precursor of indoxyl sulfate

29 October 2018

1 reference

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The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through the IL-23-->IL-17 axis

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24937185

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24937185

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.EJMECH.2014.05.076

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24937185%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24937185%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

24937185

1 reference