Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity (Q33940924)

30 July 2017

Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity (English)

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30 July 2017

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John W Harney

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30 July 2017

15

Ann Marie Zavacki

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30 July 2017

Alessandro Marsili

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30 July 2017

Cristina Aguayo-Mazzucato

2

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30 July 2017

Ting Chen

3

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30 July 2017

Aditi Kumar

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30 July 2017

Mirra Chung

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30 July 2017

Elaine P Lunsford

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30 July 2017

Thuy Van-Tran

8

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30 July 2017

Elena Gianetti

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30 July 2017

Waile Ramadan

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30 July 2017

Cyril Chou

11

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30 July 2017

Susan Bonner-Weir

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30 July 2017

Philip Reed Larsen

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30 July 2017

Jorge Enrique Silva

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30 July 2017

language of work or name

English

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publication date

16 June 2011

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30 July 2017

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30 July 2017

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30 July 2017

e20832

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Creative Commons Attribution 4.0 International

30 July 2017

start time

16 June 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Type-2 iodothyronine 5'deiodinase (D2) in skeletal muscle of C57Bl/6 mice. II. Evidence for a role of D2 in the hypermetabolism of thyroid hormone receptor alpha-deficient mice

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Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality

5 July 2018

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Pathophysiology of prediabetes

5 July 2018

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The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure

5 July 2018

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A treasure trove of hypothalamic neurocircuitries governing body weight homeostasis

5 July 2018

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The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration.

5 July 2018

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Type 2 iodothyronine deiodinase levels are higher in slow-twitch than fast-twitch mouse skeletal muscle and are increased in hypothyroidism.

5 July 2018

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Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance

5 July 2018

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Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Association of the type 2 deiodinase Thr92Ala polymorphism with type 2 diabetes: case-control study and meta-analysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Optimal bone strength and mineralization requires the type 2 iodothyronine deiodinase in osteoblasts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

The Randle cycle revisited: a new head for an old hat.

5 July 2018

1 reference

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Altered energy homeostasis and resistance to diet-induced obesity in KRAP-deficient mice

5 July 2018

1 reference

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Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes

5 July 2018

1 reference

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Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling

5 July 2018

1 reference

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Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Hypermetabolism in mice caused by the central action of an unliganded thyroid hormone receptor alpha1.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2.

5 July 2018

1 reference

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Restructuring of pancreatic islets and insulin secretion in a postnatal critical window

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Effect of weight loss with lifestyle intervention on risk of diabetes

5 July 2018

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Mechanisms of Disease: hepatic steatosis in type 2 diabetes--pathogenesis and clinical relevance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Primary prevention of type 2 diabetes mellitus by lifestyle intervention: implications for health policy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Brown adipose tissue: function and physiological significance

5 July 2018

1 reference

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A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Paradoxical resistance to diet-induced obesity in UCP1-deficient mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

betaAR signaling required for diet-induced thermogenesis and obesity resistance

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Obesity and the risk of heart failure

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Targeted disruption of the type 2 selenodeiodinase gene (DIO2) results in a phenotype of pituitary resistance to T4

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Physiological and molecular basis of thyroid hormone action

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Molecular biological and biochemical characterization of the human type 2 selenodeiodinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Kinetic evidence suggesting two mechanisms for iodothyronine 5'-deiodination in rat cerebral cortex

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

A comparison of three methods of glycogen measurement in tissues.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Potential of brown adipose tissue type II thyroxine 5'-deiodinase as a local and systemic source of triiodothyronine in rats

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Skeletal muscle metabolism is a major determinant of resting energy expenditure

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Pituitary Nuclear 3,5,3′-Triiodothyronine and Thyrotropin Secretion: An Explanation for the Effect of Thyroxine

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis.

5 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020832

Mice lacking the thyroid hormone receptor-alpha gene spend more energy in thermogenesis, burn more fat, and are less sensitive to high-fat diet-induced obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020832

LXRs regulate the balance between fat storage and oxidation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020832

Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020832

Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020832

Soy protein diet alters expression of hepatic genes regulating fatty acid and thyroid hormone metabolism in the male rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020832

Regional decrease of subcutaneous adipose tissue in patients with type 2 familial partial lipodystrophy is associated with changes in thyroid hormone metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020832

Effects of ventromedial hypothalamus stimulation on glycogenolysis in rat liver using in vivo microdialysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020832

Suprachiasmatic GABAergic inputs to the paraventricular nucleus control plasma glucose concentrations in the rat via sympathetic innervation of the liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020832

Association between a novel variant of the human type 2 deiodinase gene Thr92Ala and insulin resistance: evidence of interaction with the Trp64Arg variant of the beta-3-adrenergic receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020832

The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020832

The Thr92Ala deiodinase type 2 (DIO2) variant is not associated with type 2 diabetes or indices of insulin resistance in the old order of Amish

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020832

The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0020832

Response of glucose disposal to hyperinsulinaemia in human hypothyroidism and hyperthyroidism

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Expression and regulation of pyruvate dehydrogenase kinase isoforms in the developing rat heart and in adulthood: role of thyroid hormone status and lipid supply

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3116839

Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study

29 October 2018

1 reference

12 December 2020

Mice with impaired extrathyroidal thyroxine to 3,5,3'-triiodothyronine conversion maintain normal serum 3,5,3'-triiodothyronine concentrations

1 reference

12 December 2020

Nuclear 3,5,3'-triiodothyronine (T3) in brown adipose tissue: receptor occupancy and sources of T3 as determined by in vivo techniques

1 reference

12 December 2020

Cold exposure rapidly induces virtual saturation of brown adipose tissue nuclear T3 receptors

1 reference

12 December 2020

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

1 reference

12 December 2020

Noradrenaline and ATP decrease the secretion of triglyceride and apoprotein B from perfused rat liver

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0020832

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DOI

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30 July 2017

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30 July 2017

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