Poly-ICLC promotes the infiltration of effector T cells into intracranial gliomas via induction of CXCL10 in IFN-alpha and IFN-gamma dependent manners (Q33945653)

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English	Poly-ICLC promotes the infiltration of effector T cells into intracranial gliomas via induction of CXCL10 in IFN-alpha and IFN-gamma dependent manners	scientific article

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5 February 2020

Poly-ICLC promotes the infiltration of effector T cells into intracranial gliomas via induction of CXCL10 in IFN-alpha and IFN-gamma dependent manners (English)

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Hideho Okada

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Xinmei Zhu

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Beth A Fallert-Junecko

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Ryo Ueda

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Edward R Kastenhuber

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Heather A McDonald

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Yan Liu

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Pawel Kalinski

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Todd A Reinhart

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Andres M Salazar

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publication date

12 June 2010

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5 February 2020

Cancer Immunology, Immunotherapy

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1401-1409

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5 February 2020

https://scigraph.springernature.com/pub.10.1007/s00262-010-0876-3

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Recovery from cyclophosphamide-induced lymphopenia results in expansion of immature dendritic cells which can mediate enhanced prime-boost vaccination antitumor responses in vivo when stimulated with the TLR3 agonist poly(I:C)

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5 July 2018

Effective immunotherapy against murine gliomas using type 1 polarizing dendritic cells--significant roles of CXCL10.

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5 July 2018

The TLR3 agonist poly(I:C) targets CD8+ T cells and augments their antigen-specific responses upon their adoptive transfer into naïve recipient mice

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5 July 2018

Targeting poly(I:C) to the TLR3-independent pathway boosts effector CD8 T cell differentiation through IFN-alpha/beta

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5 July 2018

Inhibition of STAT3 promotes the efficacy of adoptive transfer therapy using type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial glioma

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5 July 2018

Toll like receptor-3 ligand poly-ICLC promotes the efficacy of peripheral vaccinations with tumor antigen-derived peptide epitopes in murine CNS tumor models

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Human effector CD8+ T lymphocytes express TLR3 as a functional coreceptor.

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TLR3-mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes: differential signaling mechanisms of TLR3-induced IP-10 and IL-8 gene expression.

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5 July 2018

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5 July 2018

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5 July 2018

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12 December 2020

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1 reference

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The adjuvant effects of the toll-like receptor 3 ligand polyinosinic-cytidylic acid poly (I:C) on antigen-specific CD8+ T cell responses are partially dependent on NK cells with the induction of a beneficial cytokine milieu

1 reference

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1 reference

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10.1007/S00262-010-0876-3

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5 February 2020

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5 February 2020

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5 February 2020

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