Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive (Q33953620)

30 July 2017

title

Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive (English)

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30 July 2017

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Courtney H Coschi

1

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30 July 2017

Alison L Martens

2

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30 July 2017

Kieran Ritchie

3

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30 July 2017

Sarah M Francis

4

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30 July 2017

Subrata Chakrabarti

5

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30 July 2017

Nathalie G Berube

6

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30 July 2017

Frederick A Dick

7

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30 July 2017

publication date

15 June 2010

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30 July 2017

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30 July 2017

volume

24

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30 July 2017

issue

13

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30 July 2017

page(s)

1351-1363

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Loss of pRB causes centromere dysfunction and chromosomal instability

30 July 2017

cites work

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Loss of Rb proteins causes genomic instability in the absence of mitogenic signaling

5 July 2018

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Mitotic chromosomal instability and cancer: mouse modelling of the human disease.

5 July 2018

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A G1 checkpoint mediated by the retinoblastoma protein that is dispensable in terminal differentiation but essential for senescence

5 July 2018

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Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity

5 July 2018

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p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis

5 July 2018

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RNAi mediated acute depletion of retinoblastoma protein (pRb) promotes aneuploidy in human primary cells via micronuclei formation.

5 July 2018

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pRb, a local chromatin organizer with global possibilities

5 July 2018

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Human condensin function is essential for centromeric chromatin assembly and proper sister kinetochore orientation.

5 July 2018

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A functional connection between pRB and transforming growth factor beta in growth inhibition and mammary gland development

5 July 2018

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The Aurora kinase family in cell division and cancer.

5 July 2018

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Cellular mechanisms of tumour suppression by the retinoblastoma gene.

5 July 2018

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RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3

5 July 2018

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Cellular senescence: when bad things happen to good cells

5 July 2018

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Condensin mutations and abnormal chromosomal structures in pyothorax-associated lymphoma

5 July 2018

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The spindle-assembly checkpoint in space and time

5 July 2018

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Mitotic chromosome structure and condensation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Condensin and Repo-Man-PP1 co-operate in the regulation of chromosome architecture during mitosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts.

5 July 2018

1 reference

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The retinoblastoma protein regulates pericentric heterochromatin

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Condensin I interacts with the PARP-1-XRCC1 complex and functions in DNA single-strand break repair

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

The condensin I subunit Barren/CAP-H is essential for the structural integrity of centromeric heterochromatin during mitosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Dynamic molecular linkers of the genome: the first decade of SMC proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

How do so few control so many?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Distinct functions of condensin I and II in mitotic chromosome assembly

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Circular binary segmentation for the analysis of array-based DNA copy number data

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Spatial and temporal regulation of Condensins I and II in mitotic chromosome assembly in human cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Overlapping functions of the pRb family in the regulation of rRNA synthesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Mutagenesis of the pRB pocket reveals that cell cycle arrest functions are separable from binding to viral oncoproteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor beta II receptor

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

pRB plays an essential role in cell cycle arrest induced by DNA damage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

No requirement for V(D)J recombination in p53-deficient thymic lymphoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Isolation and characterization of a pituitary tumor-transforming gene (PTTG)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

p53 is required for radiation-induced apoptosis in mouse thymocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Tumor spectrum analysis in p53-mutant mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Activity of RNA polymerase I transcription factor UBF blocked by Rb gene product

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Production of high-titer helper-free retroviruses by transient transfection

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Characterization of a cloned ribosomal fragment from mouse which contains the 18S coding region and adjacent spacer sequences

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Loss of ATRX leads to chromosome cohesion and congression defects

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

High resolution mapping of ribosomal DNA in early mouse embryos by fluorescence in situ hybridization.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Oncogene-induced senescence as an initial barrier in lymphoma development

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

A Two-Step Scaffolding Model for Mitotic Chromosome Assembly

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2895195

Deficiency of Retinoblastoma gene in mouse embryonic stem cells leads to genetic instability

29 October 2018

1 reference

12 December 2020

Transforming growth factor-beta pathway serves as a primary tumor suppressor in CD8+ T cell tumorigenesis

1 reference

12 December 2020

Effects of genetic background on tumorigenesis in p53-deficient mice

1 reference

12 December 2020

Control of V(D)J recombinational accessibility of the D beta 1 gene segment at the TCR beta locus by a germline promoter

1 reference

12 December 2020

Deregulated cyclin E promotes p53 loss of heterozygosity and tumorigenesis in the mouse mammary gland

1 reference

12 December 2020

hCAP-D3 Expression Marks a Prostate Cancer Subtype With Favorable Clinical Behavior and Androgen Signaling Signature

1 reference

12 December 2020

Identifiers

DOI

10.1101/GAD.1917610

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30 July 2017

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30 July 2017

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