Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis (Q33955272)

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English	Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis	scientific article

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6 March 2020

Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis (English)

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6 March 2020

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Silvia Regina Rogatto

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6 March 2020

J. Silvio Gutkind

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6 March 2020

Thomas H. Bugge

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T H Bugge

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6 March 2020

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K U Sales

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6 March 2020

S Friis

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6 March 2020

J E Konkel

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6 March 2020

S Godiksen

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6 March 2020

M Hatakeyama

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K K Hansen

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6 March 2020

R Szabo

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L K Vogel

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6 March 2020

W Chen

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27 January 2014

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6 March 2020

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6 March 2020

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6 March 2020

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6 March 2020

346-356

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6 March 2020

A matriptase-prostasin reciprocal zymogen activation complex with unique features: prostasin as a non-enzymatic co-factor for matriptase activation

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5 July 2018

Imaging a functional tumorigenic biomarker in the transformed epithelium

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5 July 2018

Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112178

5 July 2018

IL-1R-MyD88 signaling in keratinocyte transformation and carcinogenesis

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5 July 2018

Protease-activated receptor 2 signaling in inflammation

1 reference

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PAR2 absence completely rescues inflammation and ichthyosis caused by altered CAP1/Prss8 expression in mouse skin.

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c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase

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The regulatory crosstalk between kinases and proteases in cancer

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Local protease signaling contributes to neural tube closure in the mouse embryo

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Met receptor tyrosine kinase transactivation is involved in proteinase-activated receptor-2-mediated hepatocellular carcinoma cell invasion.

1 reference

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Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome

1 reference

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Matriptase: a culprit in cancer?

1 reference

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5 July 2018

Role of matriptase and proteinase-activated receptor-2 in nonmelanoma skin cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112178

5 July 2018

Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity

1 reference

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5 July 2018

Tissue factor and protease-activated receptor signaling in cancer

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5 July 2018

Kallikrein-related peptidase 4 (KLK4) initiates intracellular signaling via protease-activated receptors (PARs). KLK4 and PAR-2 are co-expressed during prostate cancer progression

1 reference

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5 July 2018

Membrane-type serine protease-1/matriptase induces interleukin-6 and -8 in endothelial cells by activation of protease-activated receptor-2: potential implications in atherosclerosis

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5 July 2018

Proteinase-activated receptors, targets for kallikrein signaling

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5 July 2018

The ratio of Matriptase/HAI-1 mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112178

5 July 2018

Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis

1 reference

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5 July 2018

p120-catenin mediates inflammatory responses in the skin

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5 July 2018

Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112178

5 July 2018

Increased expression of matriptase is associated with histopathologic grades of cervical neoplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112178

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Transmembrane serine protease TADG-15 (ST14/Matriptase/MT-SP1): expression and prognostic value in ovarian cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112178

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The membrane-anchored serine protease, TMPRSS2, activates PAR-2 in prostate cancer cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112178

5 July 2018

Gene expression profiling identifies matriptase overexpression in malignant mesothelioma

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5 July 2018

Human Airway Trypsin-Like Protease Increases Mucin Gene Expression in Airway Epithelial Cells

1 reference

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Possible role of matriptase in the diagnosis of ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112178

5 July 2018

Tissue microarray analysis of hepatocyte growth factor/Met pathway components reveals a role for Met, matriptase, and hepatocyte growth factor activator inhibitor 1 in the progression of node-negative breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4112178

5 July 2018

PARticipation in inflammation

1 reference

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Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway

1 reference

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Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase

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Proteinase-activated receptor-2-mediated activation of stress-activated protein kinases and inhibitory kappa B kinases in NCTC 2544 keratinocytes

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Molecular cloning of a potential proteinase activated receptor

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Evidence for the presence of a protease-activated receptor distinct from the thrombin receptor in human keratinocytes

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https://api.crossref.org/works/10.1038%2FONC.2013.563

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Expression of serine protease matriptase in renal cell carcinoma: correlation of tissue microarray immunohistochemical expression analysis results with clinicopathological parameters

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Increasing expression of serine protease matriptase in ovarian tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters

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Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells

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The proteinase-activated receptor-2 mediates phagocytosis in a Rho-dependent manner in human keratinocytes

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Expression of the serine protease matriptase and its inhibitor HAI-1 in epithelial ovarian cancer: correlation with clinical outcome and tumor clinicopathological parameters

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Thrombin and trypsin induce granulocyte-macrophage colony-stimulating factor and interleukin-6 gene expression in cultured normal human keratinocytes

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Type II transmembrane serine proteases

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.563

31 March 2020

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10.1038/ONC.2013.563

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6 March 2020

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