Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts (Q33965486)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10958672%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

title

Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts (English)

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9 November 2019

1

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9 November 2019

author name string

G E Beney

2

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9 November 2019

G Frebourg

3

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9 November 2019

L F Drullinger

4

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9 November 2019

G H Stein

5

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9 November 2019

language of work or name

English

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publication date

1 September 2000

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Molecular and Cellular Biology

9 November 2019

published in

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9 November 2019

volume

20

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9 November 2019

issue

18

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9 November 2019

page(s)

6741-6754

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THE LIMITED IN VITRO LIFETIME OF HUMAN DIPLOID CELL STRAINS

9 November 2019

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1 reference

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5 July 2018

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p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells

5 July 2018

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SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

5 July 2018

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Functions of the retinoblastoma protein

5 July 2018

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Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

5 July 2018

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Deregulated cyclin E induces chromosome instability

5 July 2018

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Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras.

5 July 2018

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The human papillomavirus type 16 E6 oncoprotein can down-regulate p53 activity by targeting the transcriptional coactivator CBP/p300.

5 July 2018

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5 July 2018

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Human papillomavirus (HPV) E6 interactions with Bak are conserved amongst E6 proteins from high and low risk HPV types

5 July 2018

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Induction of p21(WAF1/CIP1) and inhibition of Cdk2 mediated by the tumor suppressor p16(INK4a)

5 July 2018

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Control of replicative life span in human cells: barriers to clonal expansion intermediate between M1 senescence and M2 crisis

5 July 2018

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The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

5 July 2018

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Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts

5 July 2018

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Complete inhibition of Cdk/cyclin by one molecule of p21(Cip1)

5 July 2018

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The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation

5 July 2018

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

5 July 2018

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Senescence of human fibroblasts induced by oncogenic Raf.

5 July 2018

1 reference

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Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins

5 July 2018

1 reference

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Increased expression of cyclin D2 during multiple states of growth arrest in primary and established cells

5 July 2018

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Chromosomal instability is correlated with telomere erosion and inactivation of G2 checkpoint function in human fibroblasts expressing human papillomavirus type 16 E6 oncoprotein

5 July 2018

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Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes

5 July 2018

1 reference

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Nuclear accumulation of p21Cip1 at the onset of mitosis: a role at the G2/M-phase transition

5 July 2018

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Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86196

Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRb

5 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86196

The biology of replicative senescence

5 July 2018

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Accumulation of p16INK4a in mouse fibroblasts as a function of replicative senescence and not of retinoblastoma gene status

5 July 2018

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Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

5 July 2018

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Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts

5 July 2018

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Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution

5 July 2018

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New functional activities for the p21 family of CDK inhibitors

5 July 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

5 July 2018

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The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2

5 July 2018

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Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts

5 July 2018

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Cyclin E/Cdk2 activity is controlled by different mechanisms in the G0 and G1 phases of the cell cycle

5 July 2018

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Regulation of the retinoblastoma protein-related protein p107 by G1 cyclin-associated kinases

5 July 2018

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Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence

5 July 2018

1 reference

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Alteration of cell cycle kinase complexes in human papillomavirus E6- and E7-expressing fibroblasts precedes neoplastic transformation

5 July 2018

1 reference

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E6 of human papillomavirus type 16 can overcome the M1 stage of immortalization in human mammary epithelial cells but not in human fibroblasts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86196

Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes

5 July 2018

1 reference

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The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen

5 July 2018

1 reference

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Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes

5 July 2018

1 reference

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Different roles for cyclins D1 and E in regulation of the G1-to-S transition

5 July 2018

1 reference

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Human cyclin E, a nuclear protein essential for the G1-to-S phase transition

5 July 2018

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Increased p53 protein associated with aging in human diploid fibroblasts

5 July 2018

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Increased activity of p53 in senescing fibroblasts

5 July 2018

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Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts

5 July 2018

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Origins of G1 arrest in senescent human fibroblasts

5 July 2018

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

5 July 2018

1 reference

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Radiation-induced cell cycle arrest compromised by p21 deficiency

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86196

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86196

Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts

5 July 2018

1 reference

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Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts

5 July 2018

1 reference

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5 July 2018

p53: only ARF the story

1 reference

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Differentiation between senescence (M1) and crisis (M2) in human fibroblast cultures

29 October 2018

1 reference

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Microarray analysis of replicative senescence

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86196

p16INK4a, but not constitutively active pRb, can impose a sustained G1 arrest: molecular mechanisms and implications for oncogenesis.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86196

Two posttranscriptional pathways that regulate p21(Cip1/Waf1/Sdi1) are identified by HPV16-E6 interaction and correlate with life span and cellular senescence.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=86196

Role of the INK4a locus in tumor suppression and cell mortality.

29 October 2018

1 reference

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Escape from senescence in human diploid fibroblasts induced directly by mutant p53.

29 October 2018

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p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

29 October 2018

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Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen.

29 October 2018

1 reference

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Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts

29 October 2018

1 reference

12 December 2020

Early G1 growth arrest of hybridoma B cells by DMSO involves cyclin D2 inhibition and p21[CIP1] induction

1 reference

12 December 2020

Protein phosphatase type 1, the product of the retinoblastoma susceptibility gene, and cell cycle control

1 reference

12 December 2020

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

1 reference

12 December 2020

The bovine papillomavirus E6 protein binds to the LD motif repeats of paxillin and blocks its interaction with vinculin and the focal adhesion kinase

1 reference

12 December 2020

Role of the retinoblastoma protein family, pRB, p107 and p130 in the negative control of cell growth

1 reference

12 December 2020

A role for both RB and p53 in the regulation of human cellular senescence

1 reference

12 December 2020

Expression of p21 is not required for senescence of human fibroblasts

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12 December 2020

Cyclin E-induced S phase without activation of the pRb/E2F pathway.

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12 December 2020

10.1128/MCB.20.18.6741-6754.2000

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10958672%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10958672%20AND%20SRC:MED&resulttype=core&format=json

9 November 2019

1 reference