Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates. (Q33968014)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20551514%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates (English)

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5 February 2020

4

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5 February 2020

Jennifer E Adair

series ordinal

5

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6

Hans-Peter Kiem

1 reference

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5 February 2020

2

Grant D Trobridge

1 reference

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5 February 2020

3

Christina Ironside

1 reference

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5 February 2020

author name string

Brian C Beard

series ordinal

1

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5 February 2020

language of work or name

English

0 references

publication date

14 June 2010

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Journal of Clinical Investigation

5 February 2020

published in

1 reference

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5 February 2020

volume

120

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5 February 2020

issue

7

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5 February 2020

page(s)

2345-2354

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Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy

5 February 2020

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Busulfan pharmacokinetics, toxicity, and low-dose conditioning for autologous transplantation of genetically modified hematopoietic stem cells in the rhesus macaque model

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Distinct genomic integration of MLV and SIV vectors in primate hematopoietic stem and progenitor cells

5 July 2018

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Methylguanine methyltransferase-mediated in vivo selection and chemoprotection of allogeneic stem cells in a large-animal model

5 July 2018

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The transplantation of hematopoietic stem cells after non-myeloablative conditioning: a cellular therapeutic approach to hematologic and genetic diseases

5 July 2018

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5 July 2018

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Highly efficient gene transfer into baboon marrow repopulating cells using GALV-pseudotype oncoretroviral vectors produced by human packaging cells

5 July 2018

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5 July 2018

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Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy

5 July 2018

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Comparison of single- versus double-bolus treatments of O(6)-benzylguanine for depletion of O(6)-methylguanine DNA methyltransferase (MGMT) activity in vivo: development of a novel fluorometric oligonucleotide assay for measurement of MGMT activity

5 July 2018

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Applied molecular evolution of O6-benzylguanine-resistant DNA alkyltransferases in human hematopoietic cells

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Release of 7-methylguanine residues from alkylated DNA by extracts of Micrococcus luteus and Escherichia coli

5 July 2018

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Human lymphoblasts contain DNA glycosylase activity excising N-3 and N-7 methyl and ethyl purines but not O6-alkylguanines or 1-alkyladenines

5 July 2018

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Methylation of nucleic acids and urinary excretion of 14 C-labeled 7-methylguanine by rats and man after administration of 4(5)-(3,3-dimethyl-1-triazeno)-imidazole5(4)-carboxomide.

5 July 2018

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In vitro and in vivo methazolastone-induced DNA damage and repair in L-1210 leukemia sensitive and resistant to chloroethylnitrosoureas.

5 July 2018

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5 July 2018

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Phase 1 trial of O6-benzylguanine and BCNU in children with CNS tumors: a Children's Oncology Group study

29 October 2018

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Hematopoietic stem cell engraftment: a direct comparison between intramarrow and intravenous injection in nonhuman primates.

29 October 2018

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In vivo selection and chemoprotection after drug resistance gene therapy in a nonmyeloablative allogeneic transplantation setting in dogs

29 October 2018

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Unique integration profiles in a canine model of long-term repopulating cells transduced with gammaretrovirus, lentivirus, or foamy virus

29 October 2018

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Comparison of HIV-derived lentiviral and MLV-based gammaretroviral vector integration sites in primate repopulating cells

29 October 2018

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Efficient transduction and engraftment of G-CSF-mobilized peripheral blood CD34+ cells in nonhuman primates using GALV-pseudotyped gammaretroviral vectors

29 October 2018

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Polyclonal chemoprotection against temozolomide in a large-animal model of drug resistance gene therapy

29 October 2018

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Efficient lentiviral gene transfer to canine repopulating cells using an overnight transduction protocol

29 October 2018

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Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease.

29 October 2018

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Polyclonal long-term repopulating stem cell clones in a primate model

29 October 2018

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Sustained multilineage gene persistence and expression in dogs transplanted with CD34(+) marrow cells transduced by RD114-pseudotype oncoretrovirus vectors

29 October 2018

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Characterization of the P140K, PVP(138-140)MLK, and G156A O6-methylguanine-DNA methyltransferase mutants: implications for drug resistance gene therapy

29 October 2018

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FMEV vectors: both retroviral long terminal repeat and leader are important for high expression in transduced hematopoietic cells

29 October 2018

1 reference

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Creation of human alkyltransferases resistant to O6-benzylguanine.

29 October 2018

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Irreversible pulmonary toxicity after single course of BCNU.

29 October 2018

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Early pulmonary toxicity after administration of high-dose BCNU

29 October 2018

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12 December 2020

Optimization of fibronectin-assisted retroviral gene transfer into human CD34+ hematopoietic cells

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12 December 2020

Improved gene transfer into baboon marrow repopulating cells using recombinant human fibronectin fragment CH-296 in combination with interleukin-6, stem cell factor, FLT-3 ligand, and megakaryocyte growth and development factor

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12 December 2020

Iron metabolism in thalassemia intermedia

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12 December 2020

Dual asymmetric PCR: one-step construction of synthetic genes

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12 December 2020

Coadministration of tacrolimus and mycophenolate mofetil in stable kidney transplant patients: pharmacokinetics and tolerability

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12 December 2020

Effects of 5-(3-methyl-1-triazeno)imidazole-4-carboxamide (NSC-407347), an alkylating agent derived from 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (NSC-45388)

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12 December 2020

Identifiers

DOI

10.1172/JCI40767

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20551514%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20551514%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

PubMed publication ID

20551514

1 reference